2020
Growth hormone deficiency in a child with branchio‐oto‐renal spectrum disorder: Clinical evidence of EYA1 in pituitary development and a recommendation for pituitary function surveillance
Muthusamy K, Hanna C, Johnson D, Cramer C, Tebben P, Libi S, Poling G, Lanpher B, Morava E, Schimmenti L. Growth hormone deficiency in a child with branchio‐oto‐renal spectrum disorder: Clinical evidence of EYA1 in pituitary development and a recommendation for pituitary function surveillance. American Journal Of Medical Genetics Part A 2020, 185: 261-266. PMID: 33098377, DOI: 10.1002/ajmg.a.61942.Peer-Reviewed Case Reports and Technical NotesConceptsGrowth hormone deficiencyHormone deficiencyEYA1 genePituitary abnormalitiesInitiation of growth hormone therapyHeterozygous pathogenic variationsRare autosomal dominant conditionPituitary hormone deficiencyGrowth hormone therapyBranchial arch malformationsPathogenic variationAutosomal dominant conditionMagnetic resonance imagingAbnormal sellaPituitary imagingRenal anomaliesHormone therapyEar abnormalitiesArch malformationsFunction surveillanceClinically diagnosed individualsClinical evidencePituitary developmentPituitary glandEYA1Safety and efficacy of (+)‐epicatechin in subjects with Friedreich's ataxia: A phase II, open‐label, prospective study
Qureshi M, Patterson M, Clark V, Johnson J, Moutvic M, Driscoll S, Kemppainen J, Huston J, Anderson J, Badley A, Tebben P, Wackel P, Oglesbee D, Glockner J, Schreiner G, Dugar S, Touchette J, Gavrilova R. Safety and efficacy of (+)‐epicatechin in subjects with Friedreich's ataxia: A phase II, open‐label, prospective study. Journal Of Inherited Metabolic Disease 2020, 44: 502-514. PMID: 32677106, DOI: 10.1002/jimd.12285.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonance imagingMagnetic resonance imagingOpen-labelCardiac endpointsLeft ventricular (LV) structureFriedreich Ataxia Rating ScaleImprovement of cardiac functionLV mass indexSingle-center trialFriedreich's ataxiaCompared to baselineAtaxia Rating ScaleNonstatistically significant improvementPhase IIFA diagnosisStatistically significant improvementNeurological outcomeSignificant improvementPediatric subjectsAdverse eventsProspective studyCardiac functionHeart failureCardiac structureEvaluate safety
2019
Onset of pituitary hormone deficiencies in optic nerve hypoplasia: a temporal trend analysis of 32 children at Mayo Clinic
Wadams H, Gupta N, Novotny P, Tebben P. Onset of pituitary hormone deficiencies in optic nerve hypoplasia: a temporal trend analysis of 32 children at Mayo Clinic. Journal Of Pediatric Endocrinology And Metabolism 2019, 33: 139-145. PMID: 31811804, DOI: 10.1515/jpem-2019-0269.Peer-Reviewed Original ResearchConceptsOptic nerve hypoplasiaPituitary hormone deficiencyThyroid-stimulating hormoneMagnetic resonance imagingMidline abnormalitiesAdrenocorticotropic hormoneHormone deficiencyAntidiuretic hormoneDiagnosis of optic nerve hypoplasiaPresence of optic nerve hypoplasiaRetrospective chart review of patientsThyroid-stimulating hormone deficiencyGrowth hormoneChart review of patientsDiagnosis of GHPituitary hormone functionReview of patientsRetrospective chart reviewYears of ageAge 3 yearsMonths of ageNeonatal periodMedian ageFollow-upMayo Clinic
2007
Granulomatous Adenohypophysitis after Interferon and Ribavirin Therapy
Tebben P, Atkinson J, Scheithauer B, Erickson D. Granulomatous Adenohypophysitis after Interferon and Ribavirin Therapy. Endocrine Practice 2007, 13: 169-175. PMID: 17490932, DOI: 10.4158/ep.13.2.169.Peer-Reviewed Case Reports and Technical NotesConceptsInterferon alfa-2bGranulomatous hypophysitisMagnetic resonance imagingRibavirin therapyAlfa-2bOptic chiasmMultiple anterior pituitary hormone deficiencyTreated with interferon alfa-2bRadiographic evidenceAnterior pituitary hormone deficienciesFollow-up magnetic resonance imagingSupraphysiologic doses of prednisoneCase of granulomatous hypophysitisElevated angiotensin-converting enzyme levelDiffuse pituitary enlargementInterferon-induced thyroiditisAngiotensin-converting enzyme levelsHigh-dose glucocorticoidsResonance imagingPituitary hormone deficiencyEvidence of thyroiditisSymptoms of thyrotoxicosisDoses of glucocorticoidsDose of prednisonePhysiological doses of glucocorticoids