2020
Enteric Oxalate Secretion Mediated by Slc26a6 Defends against Hyperoxalemia in Murine Models of Chronic Kidney Disease
Neumeier LI, Thomson RB, Reichel M, Eckardt KU, Aronson PS, Knauf F. Enteric Oxalate Secretion Mediated by Slc26a6 Defends against Hyperoxalemia in Murine Models of Chronic Kidney Disease. Journal Of The American Society Of Nephrology 2020, 31: 1987-1995. PMID: 32660969, PMCID: PMC7461683, DOI: 10.1681/asn.2020010105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntiportersDisease Models, AnimalIntestinal MucosaMaleMiceMice, Inbred C57BLOxalatesRenal Insufficiency, ChronicSulfate TransportersConceptsEnteric oxalate secretionPlasma oxalate concentrationOxalate secretionModel of CKDChronic kidney diseaseIntestine of miceWild-type miceHealthy kidney functionOxalate clearanceWestern blot analysisKidney injuryKidney functionOxalate excretionWeekly injectionsKidney diseaseCKD modelExtrarenal clearanceOxalate transporter SLC26A6CKDMurine modelSignificant elevationOxalate homeostasisTransporter expressionMiceProtein expression
2016
Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice
Mulay SR, Eberhard JN, Pfann V, Marschner JA, Darisipudi MN, Daniel C, Romoli S, Desai J, Grigorescu M, Kumar SV, Rathkolb B, Wolf E, Hrabě de Angelis M, Bäuerle T, Dietel B, Wagner CA, Amann K, Eckardt KU, Aronson PS, Anders HJ, Knauf F. Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice. American Journal Of Physiology. Renal Physiology 2016, 310: f785-f795. PMID: 26764204, PMCID: PMC5504458, DOI: 10.1152/ajprenal.00488.2015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalFibroblast Growth Factor-23FibrosisHypertensionMiceMice, Inbred C57BLMyocardiumOxalic AcidRenal Insufficiency, ChronicUremiaConceptsC57BL/6 miceChronic kidney disease researchOxalate-rich dietChronic kidney diseaseFemale C57BL/6 miceArterial hypertensionCardiovascular complicationsKidney disease researchAtubular glomeruliInterstitial inflammationRenal histologyTubular damageKidney diseaseCardiac fibrosisMetabolic acidosisNormochromic anemiaTissue involvementHistological changesHuman CKDCKDExperimental animalsComplicationsInducible modelControl dietFibrosis
2013
NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy
Knauf F, Asplin JR, Granja I, Schmidt IM, Moeckel GW, David RJ, Flavell RA, Aronson PS. NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy. Kidney International 2013, 84: 895-901. PMID: 23739234, PMCID: PMC3772982, DOI: 10.1038/ki.2013.207.Peer-Reviewed Original ResearchConceptsProgressive renal failureRenal failureCalcium oxalate crystal depositionCrystal-associated diseasesOverproduction of oxalateWild-type miceHigh-oxalate dietNephropathy resultsOxalate nephropathyRenal histologyKidney diseaseOxalate dietInflammatory responseNALP3 expressionDietary oxalateIntestinal oxalateOxalate homeostasisSoluble oxalateNephropathyCrystal depositionMiceMultiple disordersNALP3DietInflammation
2006
Essential roles of CFEX-mediated Cl−–oxalate exchange in proximal tubule NaCl transport and prevention of urolithiasis
Aronson PS. Essential roles of CFEX-mediated Cl−–oxalate exchange in proximal tubule NaCl transport and prevention of urolithiasis. Kidney International 2006, 70: 1207-1213. PMID: 16883319, DOI: 10.1038/sj.ki.5001741.Commentaries, Editorials and LettersAnimalsAntiportersCalcium OxalateChloride-Bicarbonate AntiportersChloridesDisease Models, AnimalFormatesHomeostasisHumansHyperoxaluriaImmunohistochemistryIntestinal AbsorptionIon ExchangeKidney Tubules, ProximalMiceMice, KnockoutModels, BiologicalNephrolithiasisOocytesOxalatesSodium ChlorideSulfate TransportersXenopusPendrin Regulation in Mouse Kidney Primarily Is Chloride-Dependent
Vallet M, Picard N, Loffing-Cueni D, Fysekidis M, Bloch-Faure M, Deschênes G, Breton S, Meneton P, Loffing J, Aronson PS, Chambrey R, Eladari D. Pendrin Regulation in Mouse Kidney Primarily Is Chloride-Dependent. Journal Of The American Society Of Nephrology 2006, 17: 2153-2163. PMID: 16825334, DOI: 10.1681/asn.2005101054.Peer-Reviewed Original ResearchConceptsHydrochlorothiazide administrationAldosterone secretionExtracellular fluid volume regulationElevated plasma aldosterone levelsPlasma aldosterone levelsDifferent mouse modelsFluid volume regulationPendrin protein expressionAldosterone levelsSecondary hyperaldosteronismEpithelial sodium channelChloride transportApical Cl-/HCO3Chloride reabsorptionRat modelPendrin expressionMouse modelKnockout miceSemiquantitative immunoblottingNaCl loadingGamma-ENaC subunitsBiologic effectsExperimental modelSodium channelsProtein expression
2003
Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD
Thomson RB, Mentone S, Kim R, Earle K, Delpire E, Somlo S, Aronson PS. Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD. American Journal Of Physiology. Renal Physiology 2003, 285: f870-f880. PMID: 12851251, DOI: 10.1152/ajprenal.00153.2003.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAnimalsCadherinsDisease Models, AnimalEpitheliumGene SilencingImmunohistochemistryKidneyMiceMicroscopy, ElectronMicroscopy, Electron, ScanningPolycystic Kidney, Autosomal DominantProtein Kinase D2Protein KinasesSodium-Potassium-Chloride SymportersSodium-Potassium-Exchanging ATPaseSolute Carrier Family 12, Member 2Tissue DistributionConceptsCell polarityKsp-cadherinBasolateral membraneRenal cystic epitheliaEpithelial cell polarityEpithelial cellsSpecific membrane proteinsCell dedifferentiationEpithelial cell dedifferentiationE-cadherinRenal epithelial cellsCystic epithelial cellsMembrane proteinsPhenotypic transitionCl(-) cotransporter NKCC1Expression levelsATPaseSecretory isoformEarly cystsTransepithelial secretionImmunocytochemical analysisUltrastructural analysisAutosomal dominant polycystic kidney diseaseDominant polycystic kidney diseasePolycystic kidney disease
1991
Na+-H+ Exchanger and Its Role in Essential Hypertension and Diabetes Mellitus
Huot S, Aronson P. Na+-H+ Exchanger and Its Role in Essential Hypertension and Diabetes Mellitus. Diabetes Care 1991, 14: 521-535. PMID: 1650693, DOI: 10.2337/diacare.14.6.521.Commentaries, Editorials and LettersMeSH KeywordsAnimalsCarrier ProteinsDiabetes MellitusDisease Models, AnimalErythrocytesHomeostasisHumansHypertensionModels, BiologicalSodium-Hydrogen ExchangersConceptsDiabetes mellitusEssential hypertensionInsulin-dependent diabetes mellitusHigh blood pressureSubgroup of patientsBlood pressureHypertensionAnimal modelsPathophysiological statesTransepithelial absorptionAltered activityCellular mechanismsMellitusPatientsIntracellular pHPossible roleCell volume regulationVolume regulationCell growthRecent cDNA cloningNephropathyUbiquitous transport systems