2007
Ontogeny of NHE8 in the rat proximal tubule
Becker AM, Zhang J, Goyal S, Dwarakanath V, Aronson PS, Moe OW, Baum M. Ontogeny of NHE8 in the rat proximal tubule. American Journal Of Physiology. Renal Physiology 2007, 293: f255-f261. PMID: 17429030, PMCID: PMC4119019, DOI: 10.1152/ajprenal.00400.2006.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternDNA, ComplementaryElectrophoresis, Polyacrylamide GelFemaleImmunohistochemistryKidney Tubules, ProximalMicroscopy, FluorescenceMicrovilliPregnancyProteinsRatsRats, Sprague-DawleyReverse Transcriptase Polymerase Chain ReactionRNASodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersConceptsRat proximal tubuleProximal tubulesAdult ratsNHE3 expressionProximal tubule bicarbonate reabsorptionReal-time RT-PCRProton secretionNeonatal proximal tubuleNHE8 expressionApical membraneBicarbonate reabsorptionMaturational increaseMaturational changesNeonatesNHE8RT-PCRBrush border membrane vesiclesTubulesRatsCortical membrane proteinsSecretionPresent studyDevelopmental expressionAdultsBorder membrane vesiclesRole of Anion Transporter SLC26A6 (CFEX) in Prevention of Hyperoxaluria and Urolithiasis
Aronson P. Role of Anion Transporter SLC26A6 (CFEX) in Prevention of Hyperoxaluria and Urolithiasis. AIP Conference Proceedings 2007, 900: 141-148. DOI: 10.1063/1.2723570.Commentaries, Editorials and LettersProximal tubulesNull miceOxalate secretionPlasma oxalate concentrationIntestinal oxalate secretionCalcium oxalate urolithiasisFormate exchangeOxalate exchangePrevention of hyperoxaluriaHigh incidenceOxalate urolithiasisHyperoxaluriaCFEXApical membraneRenal brush border vesiclesNet absorptionMiceBrush border vesiclesTubulesUrolithiasisSecretionXenopus oocytesAnion transportersFunctional expressionSpecificity and Regulation of Renal Sulfate Transporters
Markovich D, Aronson PS. Specificity and Regulation of Renal Sulfate Transporters. Annual Review Of Physiology 2007, 69: 361-375. PMID: 17002596, DOI: 10.1146/annurev.physiol.69.040705.141319.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsProximal tubulesSulfate reabsorptionProximal tubular cellsRenal expressionApical membraneKnockout mouse studiesTubular cellsNet reabsorptionNaCl reabsorptionMouse studiesMajor roleReabsorptionSulfate homeostasisCFEXKidneyFamily membersPhysiological roleCurrent dataNormal cellular functionBasolateral membraneTubulesSLC26 family members
2006
Ion exchangers mediating Na+, HCO3 - and Cl- transport in the renal proximal tubule.
Aronson PS. Ion exchangers mediating Na+, HCO3 - and Cl- transport in the renal proximal tubule. Journal Of Nephrology 2006, 19 Suppl 9: s3-s10. PMID: 16736438.Commentaries, Editorials and LettersConceptsProximal tubulesNaCl absorptionApical membrane ClNull miceOxalate-sulfate exchangePendrin-null miceProximal tubule cellsBrush borderFormate exchangeRenal proximal tubulesSlc26a6-null miceAcid secretionPendrin expressionFunctional expression studiesTubule cellsNaCl reabsorptionCl absorptionBrush border membraneSulfate cotransportLines of evidenceExchanger isoformsTubulesMiceFamily membersBorder membrane
2005
Role of PDZK1 in membrane expression of renal brush border ion exchangers
Thomson RB, Wang T, Thomson BR, Tarrats L, Girardi A, Mentone S, Soleimani M, Kocher O, Aronson PS. Role of PDZK1 in membrane expression of renal brush border ion exchangers. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 13331-13336. PMID: 16141316, PMCID: PMC1201624, DOI: 10.1073/pnas.0506578102.Peer-Reviewed Original ResearchConceptsProximal tubulesExpression of NHE3Functional activityRole of PDZK1Protein PDZK1Reabsorption of NaBrush border expressionMammalian kidneyCFEXBrush border localizationMutant miceGST fusion proteinProtein expressionKidneyBrush border membrane proteinsExchanger NHE3Membrane expressionNHE3Brush borderBrush border membrane vesiclesPDZK1 interactionTubulesNormal expressionMembrane proteinsPDZK1
2004
Renal and intestinal transport defects in Slc26a6-null mice
Wang Z, Wang T, Petrovic S, Tuo B, Riederer B, Barone S, Lorenz JN, Seidler U, Aronson PS, Soleimani M. Renal and intestinal transport defects in Slc26a6-null mice. American Journal Of Physiology - Cell Physiology 2004, 288: c957-c965. PMID: 15574486, DOI: 10.1152/ajpcell.00505.2004.Peer-Reviewed Original ResearchConceptsWild-type miceProximal tubulesSlc26a6-null miceHCO3- secretionKidney proximal tubulesApical membrane ClNull miceBaseline rateNormal blood pressureCl-/formate exchangeBlood pressureKidney functionElectrolyte profileMucosal tissuesIntestinal physiologyUssing chambersSmall intestineMiceFluid absorptionNaCl absorptionStatistical significanceCl-/HCO3NaCl transportDuodenumTubules
2002
Formate-stimulated NaCl absorption in the proximal tubule is independent of the pendrin protein
Karniski LP, Wang T, Everett LA, Green ED, Giebisch G, Aronson PS. Formate-stimulated NaCl absorption in the proximal tubule is independent of the pendrin protein. American Journal Of Physiology. Renal Physiology 2002, 283: f952-f956. PMID: 12372770, DOI: 10.1152/ajprenal.00182.2002.Peer-Reviewed Original ResearchConceptsProximal tubulesChloride/formate exchangeNaCl reabsorptionChloride reabsorptionElectroneutral NaCl reabsorptionNaCl absorptionRole of pendrinFormate exchangePds-knockout mouseRecycling of formatePendrin proteinReabsorptionMicePendrinBrush border membrane vesiclesTubulesPresent studyChloride transportApical membraneIon exchangers mediating NaCl transport in the renal proximal tubule
Aronson PS. Ion exchangers mediating NaCl transport in the renal proximal tubule. Cell Biochemistry And Biophysics 2002, 36: 147-153. PMID: 12139400, DOI: 10.1385/cbb:36:2-3:147.Commentaries, Editorials and LettersConceptsProximal tubulesNaCl absorptionOxalate-sulfate exchangeLoop of HenleProximal tubule cellsNaCl transportRenal proximal tubulesRecycling of formateRole of NHE3NHE3 null miceTubule cellsNull micePerfusion solutionNephron segmentsIsoform-specific antibodiesApical membraneRenal brush border vesiclesMammalian proximal tubuleBrush border vesiclesSulfate cotransportBrush border membrane vesiclesTubulesFormate exchangeNHE3Stimulation
2001
Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron
Wang T, Hropot M, Aronson P, Giebisch G. Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron. American Journal Of Physiology. Renal Physiology 2001, 281: f1117-f1122. PMID: 11704563, DOI: 10.1152/ajprenal.2001.281.6.f1117.Peer-Reviewed Original ResearchConceptsLoop of HenleHOE 694Proximal tubulesAddition of ethylisopropylamilorideDistal convoluted tubuleBicarbonate reabsorptionConvoluted tubulesSitu microperfusionRat kidneySignificant inhibitionNHE isoformsHenlePredominant isoformTubulesNHE3Functional roleInhibitionNHE2Apical membraneIsoformsApical isoformKidneyMicroperfusionEthylisopropylamilorideNephron
1998
Effect of metabolic acidosis on NaCl transport in the proximal tubule
Wang T, Egbert A, Aronson P, Giebisch G. Effect of metabolic acidosis on NaCl transport in the proximal tubule. American Journal Of Physiology 1998, 274: f1015-f1019. PMID: 9841491, DOI: 10.1152/ajprenal.1998.274.6.f1015.Peer-Reviewed Original ResearchConceptsMetabolic acidosisProximal tubulesNaCl reabsorptionRat proximal tubule segmentsAcidotic ratsNaCl transportNaCl absorptionLate proximal tubuleProximal tubule segmentsControl ratsCapillary perfusateBicarbonate absorptionNephron segmentsAcidosisTubule segmentsRatsRecent evidenceJclTubulesFormate exchangeReabsorptionDifferential regulation
1995
Ontogeny of rabbit renal cortical NHE3 and NHE1: effect of glucocorticoids
Baum M, Biemesderfer D, Gentry D, Aronson PS. Ontogeny of rabbit renal cortical NHE3 and NHE1: effect of glucocorticoids. American Journal Of Physiology 1995, 268: f815-f820. PMID: 7771509, DOI: 10.1152/ajprenal.1995.268.5.f815.Peer-Reviewed Original ResearchConceptsProximal tubulesNHE1 mRNABicarbonate absorptionNHE3 mRNA abundanceDaily subcutaneous administrationAdult animalsAdministration of glucocorticoidsEffects of glucocorticoidsNHE3 protein abundanceNeonatal proximal tubuleDays of ageRenal maturationSubcutaneous administrationRenal cortexNeonatal rabbitsCortical developmentProtein abundanceRate of maturationGlucocorticoidsNHE3 mRNAAntiporter activityApical membraneNHE3Lower ratesTubulesStimulation of chloride transport by cAMP in rat proximal tubules
Wang T, Segal AS, Giebisch G, Aronson PS. Stimulation of chloride transport by cAMP in rat proximal tubules. American Journal Of Physiology 1995, 268: f204-f210. PMID: 7864157, DOI: 10.1152/ajprenal.1995.268.2.f204.Peer-Reviewed Original ResearchConceptsRat proximal tubuleProximal tubulesDibutyryl cAMPCapillary perfusateLate proximal tubuleProximal tubule cellsCl- channel blockerCl- channelsTranscellular Cl absorptionAddition of forskolinLuminal DIDSSensitive Cl- channelBasolateral membraneLuminal perfusateTubule cellsCAMP productionFluid absorptionCl absorptionMM ClPerfusateJclRecent evidenceLuminal membraneTubulesEffect of cAMP
1994
Acute Regulation of Na+:HCO3- Cotransport System In Kidney Proximal Tubules
Soleimani M, Bizal G, Hattabaugh Y, Aronson P, Bergman J. Acute Regulation of Na+:HCO3- Cotransport System In Kidney Proximal Tubules. NATO ASI Series 1994, 309-317. DOI: 10.1007/978-3-642-79301-1_36.ChaptersKidney proximal tubulesProximal tubulesKidney proximal tubule cellsProximal tubule cellsCotransport systemFiltered loadBlood pHHCO3- reabsorptionTubule cellsAcute regulatory mechanismsAcute regulationTransport of HCO3N-ethylmaleimideTubulesBasolateral membraneRecent studiesCotransporterLumenTransportersFunctional characteristicsCellsRegulatory mechanismsNumerous typesBloodSecretion
1992
Effects of formate and oxalate on volume absorption in rat proximal tubule
Wang T, Giebisch G, Aronson PS. Effects of formate and oxalate on volume absorption in rat proximal tubule. American Journal Of Physiology 1992, 263: f37-f42. PMID: 1636743, DOI: 10.1152/ajprenal.1992.263.1.f37.Peer-Reviewed Original ResearchConceptsLuminal perfusateProximal tubulesCapillary perfusateLate proximal tubuleRat proximal tubuleHCO3- Ringer's solutionPhysiological rangePeritubular capillariesChannel blockersStandard Ringer solutionPerfusateFluid absorptionStimulatory effectNaCl absorptionRinger's solutionTubulesEffect of formateBlockers
1987
Effect of formate on volume reabsorption in the rabbit proximal tubule.
Schild L, Giebisch G, Karniski LP, Aronson PS. Effect of formate on volume reabsorption in the rabbit proximal tubule. Journal Of Clinical Investigation 1987, 79: 32-38. PMID: 3793930, PMCID: PMC423979, DOI: 10.1172/jci112803.Peer-Reviewed Original ResearchConceptsProximal tubulesChloride/formate exchangeRabbit proximal tubuleNaCl reabsorptionProximal tubule S2 segmentsVolume reabsorptionElectroneutral NaCl reabsorptionNonionic diffusionFormate exchangeRabbit kidney cortexTransepithelial potential differenceActive NaCl reabsorptionKidney cortexChloride absorptionTubule fluidS2 segmentsReabsorptionGlass pH microelectrodesTubulesEffect of formateMicrovillus membranePerfusateCortex
1986
Chloride transport in the mammalian proximal tubule
Schild L, Giebisch G, Karniski L, Aronson PS. Chloride transport in the mammalian proximal tubule. Pflügers Archiv - European Journal Of Physiology 1986, 407: s156-s159. PMID: 3822761, DOI: 10.1007/bf00584945.Commentaries, Editorials and LettersConceptsMammalian proximal tubuleElectroneutral anion exchangeApical cell membraneElectroneutral transportTransport stimulationCell membraneHydrogen exchangeBrushborder membraneProximal tubule cellsChloride transportMembraneProximal tubulesTransport routesTubule cellsPossible transport mechanismsChloride/formate exchangeChloride exchangeRabbit renal cortexChloride movementSubmillimolar concentrationsTubulesVesicles
1979
Dissociation of proximal tubular glucose and Na+ reabsorption by amphotericin B
Aronson PS, Hayslett JP, Kashgarian M. Dissociation of proximal tubular glucose and Na+ reabsorption by amphotericin B. American Journal Of Physiology 1979, 236: f392-f397. PMID: 434214, DOI: 10.1152/ajprenal.1979.236.4.f392.Peer-Reviewed Original ResearchConceptsAmphotericin BGlucose reabsorptionProximal tubulesNecturus proximal tubuleGlucose uptakeTubular glucose reabsorptionStopped-flow microperfusionRenal cortexRabbit renal cortexTubular lumenReabsorptionLuminal membraneGlucoseMicrovillus membrane vesiclesTubulesUptakeAmphotericinMembrane vesicle preparationsMicroperfusion