2021
STAT6 Deficiency Attenuates Myeloid Fibroblast Activation and Macrophage Polarization in Experimental Folic Acid Nephropathy
Jiao B, An C, Du H, Tran M, Wang P, Zhou D, Wang Y. STAT6 Deficiency Attenuates Myeloid Fibroblast Activation and Macrophage Polarization in Experimental Folic Acid Nephropathy. Cells 2021, 10: 3057. PMID: 34831280, PMCID: PMC8623460, DOI: 10.3390/cells10113057.Peer-Reviewed Original ResearchConceptsFolic acid nephropathySTAT6 knockout miceM2 macrophage polarizationRenal fibrosis developmentMacrophage polarizationKidney diseaseFibroblast activationKnockout miceRenal fibrosisFibrosis developmentMyeloid fibroblastsEnd-stage kidney diseaseChronic kidney diseaseSevere interstitial fibrosisFibrotic kidney diseaseWild-type miceNovel therapeutic strategiesExtracellular matrix protein productionMatrix protein productionKidney functionPathologic featuresInterstitial fibrosisFibroblast accumulationNephropathyMouse modelPharmacological Inhibition of STAT6 Ameliorates Myeloid Fibroblast Activation and Alternative Macrophage Polarization in Renal Fibrosis
Jiao B, An C, Tran M, Du H, Wang P, Zhou D, Wang Y. Pharmacological Inhibition of STAT6 Ameliorates Myeloid Fibroblast Activation and Alternative Macrophage Polarization in Renal Fibrosis. Frontiers In Immunology 2021, 12: 735014. PMID: 34512669, PMCID: PMC8426438, DOI: 10.3389/fimmu.2021.735014.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseFolic acid administrationUnilateral ureteral obstructionRenal fibrosisM2 macrophage polarizationMacrophage polarizationUreteral obstructionFibroblast activationAcid administrationKidney functionKidney diseaseKidney fibrosisPreserves kidney functionSTAT6 activationVehicle-treated miceFolic acid nephropathyExperimental murine modelAlternative macrophage polarizationWild-type miceNovel therapeutic approachesExtracellular matrix protein productionSTAT6 inhibitorMatrix protein productionAS1517499Effective therapy
2020
CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses
Lin T, Geng T, Harrison AG, Yang D, Vella AT, Fikrig E, Wang P. CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses. Viruses 2020, 12: 1252. PMID: 33147869, PMCID: PMC7692144, DOI: 10.3390/v12111252.Peer-Reviewed Original ResearchConceptsChikungunya virusAlphaviral arthritisArthritogenic alphavirusesLargest immune cell populationMacrophages/T cellsImmune cell populationsInflammatory immune responseLow viral loadWild-type miceO'nyong-nyong virusWild-type animalsRheumatic manifestationsImmune infiltratesViral loadT cellsImmune responseAlphaviral diseaseArthritic diseasesTherapeutic targetCXCL10PathogenesisViral RNACell populationsArthritisFootpad
2011
ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitro
Dai J, Pan W, Wang P. ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitro. Virology Journal 2011, 8: 468. PMID: 21992229, PMCID: PMC3215395, DOI: 10.1186/1743-422x-8-468.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCytokinesDengue VirusMacrophagesMiceUbiquitinsVirus ReplicationWest Nile virusConceptsWest Nile virusNon-infected cellsWNV infectionViral infectionWest Nile virus infectionWest Nile meningoencephalitisInterferon beta 1Type I interferonCellular antiviral responseVirus infectionI interferonAntiviral responseFlaviviridae familyRAW264.7 cellsDENVInfectionConclusionsThese findingsBeta 1Protein ISGylationGene 15SOCS3 siRNANile virusCausative agentExact roleISG15
2009
Antibodies against a Tick Protein, Salp15, Protect Mice from the Lyme Disease Agent
Dai J, Wang P, Adusumilli S, Booth CJ, Narasimhan S, Anguita J, Fikrig E. Antibodies against a Tick Protein, Salp15, Protect Mice from the Lyme Disease Agent. Cell Host & Microbe 2009, 6: 482-492. PMID: 19917502, PMCID: PMC2843562, DOI: 10.1016/j.chom.2009.10.006.Peer-Reviewed Original ResearchConceptsArthropod-borne pathogensTick-borne BorreliaTick salivary proteinsTick proteinsB. burgdorferiLyme diseaseDisease agentsTick-borne illnessB. burgdorferi infectionLyme disease agentHuman vaccinesSalp15Infection of miceB. burgdorferi antigensMicrobial toxinsMammalian hostsBorrelia burgdorferiPathogensMechanism of actionBurgdorferi infectionProtect miceMedical importanceBurgdorferiProtective capacityMice