2002
Compensatory renal hypertrophy is mediated by a cell cycle-dependent mechanism
Liu B, Preisig PA. Compensatory renal hypertrophy is mediated by a cell cycle-dependent mechanism. Kidney International 2002, 62: 1650-1658. PMID: 12371965, DOI: 10.1046/j.1523-1755.2002.00620.x.Peer-Reviewed Original ResearchConceptsCdk2/cyclin E kinase activityCyclin E kinase activityTubule hypertrophyDay 4BrdU incorporationDevelopment of hypertrophyCyclin D kinaseCompensatory renal hypertrophyCell cycle-dependent mechanismProximal tubule proteinsTubule growthHypertrophic formUninephrectomized animalsNephrectomized ratsRenal hypertrophyC57BL6 miceRenal cortexKinase activityDay 2Proximal tubulesHypertrophyHypertrophy markersRatsKinase inhibitorsMice
1999
What Makes Cells Grow Larger and How Do They Do It? Renal Hypertrophy Revisited
Preisig P. What Makes Cells Grow Larger and How Do They Do It? Renal Hypertrophy Revisited. Experimental Nephrology 1999, 7: 273-283. PMID: 10450014, DOI: 10.1159/000020614.Peer-Reviewed Original ResearchConceptsCell cycle-dependent mechanismCell cycle-independent mechanismsCell cycle processRegulation of processesRenal hypertrophyProtein degradationChronic potassium deficiencyCompensatory renal growthChronic metabolic acidosisDevelopment of hypertrophyCompensatory renal hypertrophyPotassium deficiencyDiabetes mellitusMetabolic acidosisLysosomal enzymesRenal growthCell sizeHypertrophyCell numberInitial eventProtein feedingRegulationVivo studiesCell culture studiesCycle process