2014
Safety and Effectiveness of Bevacizumab-Containing Treatment for Non–Small-Cell Lung Cancer: Final Results of the ARIES Observational Cohort Study
Lynch TJ, Spigel DR, Brahmer J, Fischbach N, Garst J, Jahanzeb M, Kumar P, Vidaver RM, Wozniak AJ, Fish S, Flick ED, Leon L, Hazard SJ, Kosty MP, Investigators O. Safety and Effectiveness of Bevacizumab-Containing Treatment for Non–Small-Cell Lung Cancer: Final Results of the ARIES Observational Cohort Study. Journal Of Thoracic Oncology 2014, 9: 1332-1339. PMID: 25122429, DOI: 10.1097/jto.0000000000000257.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngiogenesis InhibitorsAntibodies, Monoclonal, HumanizedAntineoplastic AgentsBevacizumabCarcinoma, Non-Small-Cell LungDisease-Free SurvivalDrug Therapy, CombinationEuropeFemaleFollow-Up StudiesHumansLung NeoplasmsMaleMiddle AgedProspective StudiesSurvival RateTime FactorsTreatment OutcomeUnited StatesVascular Endothelial Growth Factor AConceptsTrial of bevacizumabObservational cohort studyCell lung cancerCohort studyLung cancerARIES observational cohort studyBevacizumab-associated adverse eventsMedian progression-free survivalProspective observational cohort studyReal-world patient populationRecombinant humanized monoclonal antibodyFirst-line bevacizumabProtocol-defined treatmentMedian overall survivalProgression-free survivalEffectiveness of bevacizumabCommunity-based populationHumanized monoclonal antibodyVascular endothelial growth factorEndothelial growth factorSquamous histologyAdvanced NSCLCChemotherapy regimenMetastatic NSCLCAdverse events
2004
HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo
Fischbach NA, Rozenfeld S, Shen W, Fong S, Chrobak D, Ginzinger D, Kogan SC, Radhakrishnan A, Le Beau MM, Largman C, Lawrence HJ. HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo. Blood 2004, 105: 1456-1466. PMID: 15522959, DOI: 10.1182/blood-2004-04-1583.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsBone Marrow CellsCell DifferentiationCell Line, TransformedCell ProliferationCell Transformation, NeoplasticErythropoiesisFemaleHomeodomain ProteinsKaryotypingLeukemia, MyeloidLymphopoiesisMiceMice, CongenicMice, Inbred C57BLMyeloid Ecotropic Viral Integration Site 1 ProteinMyeloid Progenitor CellsNeoplasm ProteinsPhenotypeTime FactorsConceptsHematopoietic stem cellsMurine bone marrowPre-B-cell leukemia transcription factor 1Potential cooperative interactionsHox gene expressionMyelomonocytic precursorsHematopoietic stem cell expansionStructure-function relationshipsStem cell expansionHox genesTranscription factor 1Homeobox genesHox familyHuman myeloid leukemiaDNA bindingGene expressionMalignant hematopoiesisHOXB6Gene transferAberrant activationMonocytic differentiationCell expansionDirect interactionStem cellsHuman acute myeloid leukemia