2020
Intraoperative Oxidative Damage and Delirium after Cardiac Surgery.
Lopez MG, Hughes CG, DeMatteo A, O’Neal J, McNeil JB, Shotwell MS, Morse J, Petracek MR, Shah AS, Brown NJ, Billings FT. Intraoperative Oxidative Damage and Delirium after Cardiac Surgery. Anesthesiology 2020, 132: 551-561. PMID: 31770146, PMCID: PMC7015795, DOI: 10.1097/aln.0000000000003016.Peer-Reviewed Original ResearchConceptsS100 calcium-binding protein BCalcium-binding protein BUbiquitin carboxyl-terminal hydrolase isozyme L1Blood-brain barrier disruptionNeuronal injuryPostoperative deliriumF2-isoprostanesBarrier disruptionOxidative damageConfusion Assessment MethodCardiac surgery patientsPostoperative day 1Intensive care unitBlood-brain barrierEnzyme-linked immunosorbentProtein BKidney injuryCohort studySurgery patientsCardiac surgeryTotal cohortCare unitIndependent associationClinical trialsPlasma concentrations
2018
Fish Oil Supplementation Does Not Affect Cognitive Outcomes in Cardiac Surgery Patients in the Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation (OPERA) Trial
Jackson JC, Mozaffarian D, Graves AJ, Brown NJ, Marchioli R, Kiehl AL, Ely EW. Fish Oil Supplementation Does Not Affect Cognitive Outcomes in Cardiac Surgery Patients in the Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation (OPERA) Trial. Journal Of Nutrition 2018, 148: 472-479. PMID: 29546292, PMCID: PMC6454465, DOI: 10.1093/jn/nxx002.Peer-Reviewed Original ResearchConceptsOmega-3 fatty acidsCognitive declineCardiac surgeryTertiary care medical centerGlobal cognitionAtrial Fibrillation (ARISTOTLE) trialCardiac surgery patientsCardiac surgical patientsPostoperative cognitive declinePostoperative day 10Mini-Mental State ExamFatty acidsPerioperative supplementationPreoperative loadingPostcardiac surgeryHospital dischargeSurgery patientsSurgical patientsMedian agePrimary outcomePostoperative careUS patientsPUFA supplementationSurgery recipientsClinical trials
2016
High-Dose Perioperative Atorvastatin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial
Billings FT, Hendricks PA, Schildcrout JS, Shi Y, Petracek MR, Byrne JG, Brown NJ. High-Dose Perioperative Atorvastatin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial. JAMA 2016, 315: 877. PMID: 26906014, PMCID: PMC4843765, DOI: 10.1001/jama.2016.0548.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAged, 80 and overAspartate AminotransferasesAtorvastatinCardiac Surgical ProceduresCreatinineDouble-Blind MethodDrug Administration ScheduleFemaleGlomerular Filtration RateHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMedication AdherenceMiddle AgedPostoperative ComplicationsRenal Insufficiency, ChronicConceptsAcute kidney injuryMorning of surgerySerum creatinine concentrationPlacebo groupCardiac surgeryStatin treatmentAtorvastatin groupKidney injuryClinical trialsCreatinine concentrationAcute Kidney Injury Following Cardiac SurgeryAdult cardiac surgery patientsCardiac surgery patientsChronic kidney diseaseHours of surgeryPostoperative day 2Day of surgerySafety monitoring boardVanderbilt University Medical CenterUniversity Medical CenterAtorvastatin dailyStatin therapyAtorvastatin treatmentSurgery patientsKidney disease
2015
Oxidative Stress Biomarkers and Incidence of Postoperative Atrial Fibrillation in the Omega‐3 Fatty Acids for Prevention of Postoperative Atrial Fibrillation (OPERA) Trial
Wu JH, Marchioli R, Silletta MG, Masson S, Sellke FW, Libby P, Milne GL, Brown NJ, Lombardi F, Damiano RJ, Marsala J, Rinaldi M, Domenech A, Simon C, Tavazzi L, Mozaffarian D. Oxidative Stress Biomarkers and Incidence of Postoperative Atrial Fibrillation in the Omega‐3 Fatty Acids for Prevention of Postoperative Atrial Fibrillation (OPERA) Trial. Journal Of The American Heart Association 2015, 4: e001886. PMID: 25994442, PMCID: PMC4599415, DOI: 10.1161/jaha.115.001886.Peer-Reviewed Original ResearchConceptsEnd of surgeryOxidative stress biomarkersPostoperative atrial fibrillationPostoperative day 2Stress biomarkersAtrial fibrillationOxidative stressDay 2Omega-3 fatty acidsCardiac surgery patientsAtrial Fibrillation (ARISTOTLE) trialKey pathogenic rolePostoperative day 10Urine F2-isoprostanesAssociation of biomarkersBaseline biomarker levelsElevated oxidative stressAnimal study resultsPerioperative courseHospital dischargeSurgery patientsMedication useSurgery typeUrine levelsBiomarker levels
2013
Plasma Phospholipid Omega‐3 Fatty Acids and Incidence of Postoperative Atrial Fibrillation in the OPERA Trial
Wu JH, Marchioli R, Silletta MG, Macchia A, Song X, Siscovick DS, Harris WS, Masson S, Latini R, Albert C, Brown NJ, Lamarra M, Favaloro RR, Mozaffarian D. Plasma Phospholipid Omega‐3 Fatty Acids and Incidence of Postoperative Atrial Fibrillation in the OPERA Trial. Journal Of The American Heart Association 2013, 2: e000397. PMID: 24145742, PMCID: PMC3835252, DOI: 10.1161/jaha.113.000397.Peer-Reviewed Original ResearchConceptsFish oil supplementationMorning of surgeryPostoperative atrial fibrillationCardiac surgeryOil supplementationDocosapentaenoic acidAtrial fibrillationDocosahexaenoic acidEicosapentaenoic acidShort-term fish oil supplementationPUFA levelsOmega-3 fatty acidsCardiac surgery patientsPlasma phospholipid nPostoperative day 10Substantial interindividual variabilityOPERA trialPoAF episodesPlacebo supplementationPrimary endpointSecondary endpointsHospital dischargeSurgery patientsAntiarrhythmic potentialFatty acids
2012
Contribution of Endogenous Bradykinin to Fibrinolysis, Inflammation, and Blood Product Transfusion Following Cardiac Surgery: A Randomized Clinical Trial
Balaguer JM, Yu C, Byrne JG, Ball SK, Petracek MR, Brown NJ, Pretorius M. Contribution of Endogenous Bradykinin to Fibrinolysis, Inflammation, and Blood Product Transfusion Following Cardiac Surgery: A Randomized Clinical Trial. Clinical Pharmacology & Therapeutics 2012, 93: 326-334. PMID: 23361105, PMCID: PMC4031681, DOI: 10.1038/clpt.2012.249.Peer-Reviewed Original ResearchConceptsBradykinin B2 receptor antagonismB2 receptor antagonismCardiopulmonary bypassEndogenous bradykininTissue-type plasminogen activatorHoe 140Receptor antagonismBradykinin B2 receptor antagonistSubsequent transfusion requirementsBlood product transfusionProportion of patientsB2 receptor antagonistD-dimer concentrationD-dimer formationEACA treatmentTransfusion requirementsPostoperative bleedingProduct transfusionBlood lossCardiac surgeryInflammatory cytokinesReceptor antagonistClinical trialsFibrinolytic capacityInflammatory responseObesity and Oxidative Stress Predict AKI after Cardiac Surgery
Billings FT, Pretorius M, Schildcrout JS, Mercaldo ND, Byrne JG, Ikizler TA, Brown NJ. Obesity and Oxidative Stress Predict AKI after Cardiac Surgery. Journal Of The American Society Of Nephrology 2012, 23: 1221-1228. PMID: 22626819, PMCID: PMC3380645, DOI: 10.1681/asn.2011090940.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAngiotensin-Converting Enzyme InhibitorsBiomarkersBody Mass IndexCardiac Surgical ProceduresDiureticsF2-IsoprostanesFemaleHumansInterleukin-6MaleMiddle AgedObesityOxidative StressPlasminogen Activator Inhibitor 1Postoperative ComplicationsRamiprilRandomized Controlled Trials as TopicRisk FactorsSignal TransductionSpironolactoneComparative Effects of Angiotensin Receptor Blockade and ACE Inhibition on the Fibrinolytic and Inflammatory Responses to Cardiopulmonary Bypass
Billings F, Balaguer J, Yu C, Wright P, Petracek M, Byrne J, Brown N, Pretorius M. Comparative Effects of Angiotensin Receptor Blockade and ACE Inhibition on the Fibrinolytic and Inflammatory Responses to Cardiopulmonary Bypass. Clinical Pharmacology & Therapeutics 2012, 91: 1065-1073. PMID: 22549281, PMCID: PMC3822756, DOI: 10.1038/clpt.2011.356.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngiotensin II Type 1 Receptor BlockersAngiotensin-Converting Enzyme InhibitorsBenzimidazolesBiphenyl CompoundsBlood TransfusionBradykininCardiopulmonary BypassEndpoint DeterminationFemaleFibrinolysisHematocritHospital MortalityHumansInflammationInterleukinsLength of StayMaleMiddle AgedMonitoring, IntraoperativePerioperative CarePostoperative ComplicationsRamiprilTetrazolesTreatment OutcomeConceptsAngiotensin II type 1 receptor blockadeACE inhibitionCardiopulmonary bypassReceptor blockadeInflammatory responseType 1 receptor blockadeTissue-type plasminogen activator concentrationAngiotensin receptor blockadeEffect of angiotensinRed cell transfusionDay of surgeryPlasminogen activator inhibitor-1Activator inhibitor-1Plasminogen activator concentrationsHospital stayPlasma transfusionIL-10ACE inhibitorsIL-8Intraoperative fibrinolysisFibrinolysisInhibitor-1Comparative effectsPlaceboTransfusion
2011
Prospective study of the incidence and predictors of thrombus in children undergoing palliative surgery for single ventricle physiology
Todd Tzanetos DR, Yu C, Hernanz-Schulman M, Barr FE, Brown NJ. Prospective study of the incidence and predictors of thrombus in children undergoing palliative surgery for single ventricle physiology. Intensive Care Medicine 2011, 38: 105-112. PMID: 21979273, PMCID: PMC4747610, DOI: 10.1007/s00134-011-2378-y.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersCentral Nervous SystemChild, PreschoolFemaleHeart Defects, CongenitalHeart VentriclesHospitals, PediatricHumansInfantInfant, NewbornMaleMedical AuditPalliative CarePerioperative CarePostoperative ComplicationsPredictive Value of TestsProspective StudiesTennesseeThrombosisUltrasonographyConceptsSingle ventricle physiologyTissue plasminogen activator antigenCardiopulmonary bypass timePlasminogen activator antigenPlasma antithrombin IIIVentricle physiologyAntithrombin IIIBypass timePalliative surgeryVentricular functionTissue plasminogen activator antigen concentrationAortic cross-clamp timeCentral venous catheter daysLonger cardiopulmonary bypass timePoor preoperative ventricular functionPredictors of thrombusPreoperative ventricular functionChest tube outputCross-clamp timeBiomarkers of coagulationBlood product administrationLow antithrombin IIICentral venous systemIntensive care unitPlasminogen activator inhibitor-1
2010
Early Postoperative Statin Therapy Is Associated With a Lower Incidence of Acute Kidney Injury After Cardiac Surgery
Billings FT, Pretorius M, Siew ED, Yu C, Brown NJ. Early Postoperative Statin Therapy Is Associated With a Lower Incidence of Acute Kidney Injury After Cardiac Surgery. Journal Of Cardiothoracic And Vascular Anesthesia 2010, 24: 913-920. PMID: 20599398, PMCID: PMC2992577, DOI: 10.1053/j.jvca.2010.03.024.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAnesthesiaAnticoagulantsAprotininAtrial FibrillationBody Mass IndexCardiac Surgical ProceduresCardiopulmonary BypassCritical CareFemaleHemostaticsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsKidney Function TestsLogistic ModelsMaleMiddle AgedPostoperative CarePostoperative ComplicationsRisk AssessmentTreatment OutcomeConceptsAcute kidney injuryPostoperative statin usePreoperative statin useStatin useCardiac surgery patientsBody mass indexStatin withdrawalKidney injuryStatin treatmentSurgery patientsCardiac surgeryMass indexLower incidenceIncidence of AKIRisk of AKIHigh central venous pressureElective cardiac surgery patientsHigher body mass indexLogistic regressionAKI risk factorsChronic statin usersPerioperative statin usePostoperative statin therapyPreoperative statin treatmentCentral venous pressure
2009
Variation in the 4q25 Chromosomal Locus Predicts Atrial Fibrillation After Coronary Artery Bypass Graft Surgery
Body SC, Collard CD, Shernan SK, Fox AA, Liu KY, Ritchie MD, Perry T, Muehlschlegel JD, Aranki S, Donahue BS, Pretorius M, Estrada JC, Ellinor PT, Newton-Cheh C, Seidman CE, Seidman JG, Herman; D, Lichtner P, Meitinger T, Pfeufer A, Kääb S, Brown NJ, Roden DM, Darbar D. Variation in the 4q25 Chromosomal Locus Predicts Atrial Fibrillation After Coronary Artery Bypass Graft Surgery. Circulation Genomic And Precision Medicine 2009, 2: 499-506. PMID: 20031626, PMCID: PMC2801871, DOI: 10.1161/circgenetics.109.849075.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryArtery bypass graft surgeryPostoperative atrial fibrillationBypass graft surgeryGraft surgeryAtrial fibrillationSingle nucleotide polymorphismsValidation cohortDiscovery cohortCardiac surgery cohortConcurrent valve surgeryCommon adverse eventsCohort of patientsAdditive odds ratioMultiple comparisonsChromosome 4q25 variantsSurgery cohortValve surgeryAdverse eventsClinical predictorsAmbulatory populationOdds ratioClinical covariatesUS CentersMultivariate predictors
2008
Milrinone Use Is Associated With Postoperative Atrial Fibrillation After Cardiac Surgery
Fleming GA, Murray KT, Yu C, Byrne JG, Greelish JP, Petracek MR, Hoff SJ, Ball SK, Brown NJ, Pretorius M. Milrinone Use Is Associated With Postoperative Atrial Fibrillation After Cardiac Surgery. Circulation 2008, 118: 1619-1625. PMID: 18824641, PMCID: PMC2770257, DOI: 10.1161/circulationaha.108.790162.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAtrial FibrillationCardiac Surgical ProceduresCardiotonic AgentsCoronary DiseaseElective Surgical ProceduresFemaleHumansHypertensionLength of StayLogistic ModelsMaleMiddle AgedMilrinoneMitral Valve InsufficiencyMultivariate AnalysisPostoperative ComplicationsPulmonary Wedge PressureRisk FactorsConceptsPostoperative atrial fibrillationPulmonary artery pressureElective cardiac surgeryMilrinone useMitral valve surgeryAtrial fibrillationCardiac surgeryArtery pressureValve surgeryInotropic drugsEjection fractionRisk factorsLow preoperative ejection fractionHigh pulmonary artery pressurePerioperative risk factorsPreoperative ejection fractionRight ventricular dysfunctionIndependent risk factorPulmonary artery catheterMultivariable logistic regressionProlong hospitalizationVentricular dysfunctionArtery catheterFrequent complicationVentricular function
2007
Plasminogen Activator Inhibitor-1 as a Predictor of Postoperative Atrial Fibrillation After Cardiopulmonary Bypass
Pretorius M, Donahue BS, Yu C, Greelish JP, Roden DM, Brown NJ. Plasminogen Activator Inhibitor-1 as a Predictor of Postoperative Atrial Fibrillation After Cardiopulmonary Bypass. Circulation 2007, 116: i-1-i-7. PMID: 17846288, DOI: 10.1161/circulationaha.106.677906.Peer-Reviewed Original ResearchConceptsPostoperative atrial fibrillationPAI-1 antigen concentrationsCardiopulmonary bypassAtrial fibrillationPlasminogen activator inhibitor-1Remote historyIndependent predictorsActivator inhibitor-1Antigen concentrationPAI-1Development of AFRisk of AFInhibitor-1Administration of protaminePreoperative PAI-1Elective cardiac surgeryTime of surgeryPAI-1 concentrationsBlood of patientsHospital stayValve surgeryAdult patientsYounger patientsCardiac surgerySignificant morbidity
2006
Risk factor interactions and genetic effects associated with post-operative atrial fibrillation.
Motsinger AA, Donahue BS, Brown NJ, Roden DM, Ritchie MD. Risk factor interactions and genetic effects associated with post-operative atrial fibrillation. Biocomputing 2006, 584-95. PMID: 17094271.Peer-Reviewed Original ResearchConceptsDevelopment of PoAFPostoperative atrial fibrillationAtrial fibrillationDisease statusPost-operative atrial fibrillationHistory of AFRisk factor interactionsGenetic risk factorsPOAF riskHospital stayClinical factorsGeneral anesthesiaCommon arrhythmiaHeart surgeryIL-6Elective proceduresRisk factorsAF casesGreat vesselsGene-environment interactionsPoAFPotential associationAdult subjectsTotal sample sizeFibrillation
2005
A pilot study indicating that bradykinin B2 receptor antagonism attenuates protamine‐related hypotension after cardiopulmonary bypass
Pretorius M, Scholl FG, McFarlane JA, Murphey LJ, Brown NJ. A pilot study indicating that bradykinin B2 receptor antagonism attenuates protamine‐related hypotension after cardiopulmonary bypass. Clinical Pharmacology & Therapeutics 2005, 78: 477-485. PMID: 16321614, DOI: 10.1016/j.clpt.2005.08.010.Peer-Reviewed Original ResearchConceptsMean arterial pressureSaline solution groupT-PA activityAdministration of protamineCardiopulmonary bypassProtamine administrationHoe 140Receptor antagonismBradykinin concentrationsSolution groupTissue-type plasminogen activator releaseACE inhibitor-treated patientsBradykinin B2 receptor antagonismReceptor antagonist HOE 140Angiotensin-converting enzyme inhibitorB2 receptor antagonismInhibitor-treated patientsElective cardiac surgeryAdult male patientsBradykinin receptor antagonismDegradation of bradykininPlasminogen activator releaseSaline solutionProtamine infusionArterial pressure
1999
Clinical Experience Over 48 Years With Pheochromocytoma
Goldstein R, O’Neill J, Holcomb G, Morgan W, Neblett W, Oates J, Brown N, Nadeau J, Smith B, Page D, Abumrad N, Scott H. Clinical Experience Over 48 Years With Pheochromocytoma. Annals Of Surgery 1999, 229: 755. PMID: 10363888, PMCID: PMC1420821, DOI: 10.1097/00000658-199906000-00001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenal Gland NeoplasmsAdultAgedChildFemaleHumansMaleMiddle AgedPheochromocytomaPostoperative ComplicationsSurvival RateTime FactorsTreatment OutcomeConceptsMicroscopic malignant featuresExtraadrenal pheochromocytomaMalignant diseaseMalignant featuresAdrenal pheochromocytomaSurgical managementMultiple endocrine neoplasia type 2Von Hippel-Lindau diseasePatient's malignant diseaseSame overall survivalLong-term outcomesRate of malignancyKaplan-Meier survival distributionsNumber of patientsVon Recklinghausen's diseaseHippel-Lindau diseaseAreas of controversyCarney syndromeAdrenal tumorsOverall survivalMale patientsFemale patientsBenign diseasePatient survivalFormer tumor