2012
Zyxin Is a Transforming Growth Factor-β (TGF-β)/Smad3 Target Gene That Regulates Lung Cancer Cell Motility via Integrin α5β1*
Mise N, Savai R, Yu H, Schwarz J, Kaminski N, Eickelberg O. Zyxin Is a Transforming Growth Factor-β (TGF-β)/Smad3 Target Gene That Regulates Lung Cancer Cell Motility via Integrin α5β1*. Journal Of Biological Chemistry 2012, 287: 31393-31405. PMID: 22778267, PMCID: PMC3438968, DOI: 10.1074/jbc.m112.357624.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Adhesion MoleculesCell Line, TumorCell MovementFocal AdhesionsGene SilencingHumansIntegrin alpha5beta1Intercellular JunctionsLung NeoplasmsMiceMice, Mutant StrainsMicrofilament ProteinsPhosphoproteinsProto-Oncogene Proteins p21(ras)Signal TransductionSmad3 ProteinTransforming Growth Factor beta1ZyxinConceptsEpithelial-mesenchymal transitionCancer cell motilityCell motilityFocal adhesionsZyxin expressionCell-extracellular matrix adhesionLung cancer cellsFocal adhesion proteinsSingle cell motilityCell-cell junctionsCell adherens junctionsNovel functional targetSingle cell migrationLung cancer cell motilityCancer cellsNovel direct targetZyxin geneTGF-β signalingTumor suppressor effectActin cytoskeletonAdherens junctionsCytoskeletal organizationZyxinTarget genesAdhesion proteins
2008
Transgelin is a direct target of TGF‐β/Smad3‐dependent epithelial cell migration in lung fibrosis
Yu H, Königshoff M, Jayachandran A, Handley D, Seeger W, Kaminski N, Eickelberg O. Transgelin is a direct target of TGF‐β/Smad3‐dependent epithelial cell migration in lung fibrosis. The FASEB Journal 2008, 22: 1778-1789. PMID: 18245174, DOI: 10.1096/fj.07-083857.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisReverse transcription-polymerase chain reactionLung fibrosisATII cellsPulmonary fibrosisType II cell hyperplasiaExcessive extracellular matrix depositionATII cell phenotypeCell phenotypeTranscription-polymerase chain reactionLung epithelial A549 cellsPrimary ATII cellsActivin-like kinase 5Epithelial A549 cellsTGF-beta treatmentExtracellular matrix depositionTransgelin geneIPF patientsTGF-beta signalingCell hyperplasiaTGF-beta target genesCell injuryLung specimenFibrosisFatal disease