2022
Interspecies commensal interactions have nonlinear impacts on host immunity
Rice TA, Bielecka AA, Nguyen MT, Rosen CE, Song D, Sonnert ND, Yang Y, Cao Y, Khetrapal V, Catanzaro JR, Martin AL, Rashed SA, Leopold SR, Hao L, Yu X, van Dijk D, Ring AM, Flavell RA, de Zoete MR, Palm NW. Interspecies commensal interactions have nonlinear impacts on host immunity. Cell Host & Microbe 2022, 30: 988-1002.e6. PMID: 35640610, PMCID: PMC9283318, DOI: 10.1016/j.chom.2022.05.004.Peer-Reviewed Original ResearchConceptsImmunological outcomesCell activationIntestinal epithelial cell activationInflammatory bowel disease patientsBowel disease patientsDendritic cell activationMesenteric lymph nodesSystemic antibody responsesEpithelial cell activationImmunological milieuLymph nodesAntibody responseDisease patientsAkkermansia muciniphilaGnotobiotic miceHost immunityCommensal microbesHuman cohortsHuman gut bacteriaGut bacteriaMiceAllobaculumMuciniphilaDiseaseIncomplete penetrance
2016
The fermentation product 2,3-butanediol alters P. aeruginosa clearance, cytokine response and the lung microbiome
Nguyen M, Sharma A, Wu W, Gomi R, Sung B, Hospodsky D, Angenent LT, Worgall S. The fermentation product 2,3-butanediol alters P. aeruginosa clearance, cytokine response and the lung microbiome. The ISME Journal: Multidisciplinary Journal Of Microbial Ecology 2016, 10: 2978-2983. PMID: 27177192, PMCID: PMC5148197, DOI: 10.1038/ismej.2016.76.Peer-Reviewed Original ResearchConceptsEnvironmental microbesFermentation productsP. aeruginosa persistenceP. aeruginosa virulenceRespiratory tractLung microbiotaBacterial fermentation productsLung microbiomeP. aeruginosa respiratory tract infectionsP. aeruginosaP. aeruginosa clearanceRespiratory tract infectionsBiofilm formationMurine respiratory tractIL-6 responseDisease susceptibilityVirulenceMicrobiomeMicrobesColonizationTract infectionsAirway microbiomeCytokine responsesInflammatory responseMicrobiota diversity