2023
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Young J, Park H, Kim M, Par-Young J, Bartlett H, Kim H, Unlu S, Osmani L, Shin M, Bucala R, van Dyck C, Allore H, Mecca A, You S, Kang I. Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease. Immunity & Ageing 2023, 20: 71. PMID: 38042785, PMCID: PMC10693128, DOI: 10.1186/s12979-023-00396-y.Peer-Reviewed Original ResearchPeripheral bloodT cellsAlzheimer's diseaseEM CD8Memory CD8Gene signatureAge-related immune changesIL-7 receptor alphaEffector memory CD8Strong risk factorT cell expansionAD genesAge-associated expansionImmune changesRisk factorsCD8Dementia patientsIL-7RNeuropsychological testingReceptor alphaNeurocognitive functionRT-qPCR resultsDisease severityPatientsNormal persons
2020
Defining heterogeneity and biological signature in human effector memory CD8+ T cells expressing different levels of IL-7 receptor alpha by high-dimensional analysis
Shin M, Kim D, Park H, Dong X, Koumpouras F, Kang I. Defining heterogeneity and biological signature in human effector memory CD8+ T cells expressing different levels of IL-7 receptor alpha by high-dimensional analysis. The Journal Of Immunology 2020, 204: 154.19-154.19. DOI: 10.4049/jimmunol.204.supp.154.19.Peer-Reviewed Original ResearchHuman effector memory CD8EM CD8Effector memory CD8T cellsIL-7RαMemory CD8Cell subsetsIL-7 receptor alphaIL-7 receptor alpha chainT cell subsetsCo-stimulatory moleculesT cell heterogeneityHigh-dimensional single-cell analysisReceptor alpha chainLupus patientsImmune landscapeCell surface moleculesHeterogeneous cell subsetsT-betCD8Effector functionsDifferential expressionReceptor alphaSingle-cell RNA-seq analysisPathologic conditions
2012
The Relationship of Cytomegalovirus (CMV) Infection with circulatory IFN-α levels and IL-7 receptor α expression on CD8+ T cells in Human Aging (105.16)
Lee N, Lee W, Shin M, Kang Y, Jeon S, Kang I. The Relationship of Cytomegalovirus (CMV) Infection with circulatory IFN-α levels and IL-7 receptor α expression on CD8+ T cells in Human Aging (105.16). The Journal Of Immunology 2012, 188: 105.16-105.16. DOI: 10.4049/jimmunol.188.supp.105.16.Peer-Reviewed Original ResearchEM CD8IFN-α levelsT cellsCMV infectionCytomegalovirus infectionIL-7 Receptor α ExpressionHuman effector memory CD8IL-7 receptor alphaCMV immune statusEffector memory CD8Elderly peopleT cell subsetsReceptor α expressionT cell homeostasisAge-associated expansionHigh-affinity receptorCytokine levelsMemory CD8Naïve CD8Cell subsetsImmune statusPlasma levelsCD8IL-7Α expression
2011
Expansion of IL-7Ralow memory CD8 T cells in human lupus (101.19)
Lee N, Shah K, Shin M, Kim S, Craft J, Kang I. Expansion of IL-7Ralow memory CD8 T cells in human lupus (101.19). The Journal Of Immunology 2011, 186: 101.19-101.19. DOI: 10.4049/jimmunol.186.supp.101.19.Peer-Reviewed Original ResearchSystemic lupus erythematosusDevelopment of SLESLE Disease Activity IndexMemory CD8SLE patientsT cellsCell subsetsHealthy controlsImmunopathogenesis of SLEAbstract Systemic lupus erythematosusHomeostatic cytokine IL-15IL-7 receptor alphaMemory CD8 T cellsCytotoxic molecules perforinHomeostasis of CD8Disease activity indexRole of CD8Cytokine IL-15CD8 T cellsImmune complex depositionProduction of autoantibodiesInflammatory autoimmune disorderT cell receptorDisease activityLupus erythematosus