2001
Serial Motion Assessment by Reference Tracking (SMART): Application to Detection of Local Functional Impact of Chronic Myocardial Ischemia
Pearlman J, Gertz Z, Wu Y, Simons M, Post M. Serial Motion Assessment by Reference Tracking (SMART): Application to Detection of Local Functional Impact of Chronic Myocardial Ischemia. Journal Of Computer Assisted Tomography 2001, 25: 558-562. PMID: 11473185, DOI: 10.1097/00004728-200107000-00008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCoronary DiseaseDisease Models, AnimalHeart VentriclesMagnetic Resonance ImagingMaleMyocardial IschemiaSensitivity and SpecificitySwine
2000
Intracoronary basic fibroblast growth factor (FGF-2) in patients with severe ischemic heart disease: results of a Phase I open-label dose escalation study
Laham R, Chronos N, Pike M, Leimbach M, Udelson J, Pearlman J, Pettigrew R, Whitehouse MJ, Yoshizawa C, Simons M. Intracoronary basic fibroblast growth factor (FGF-2) in patients with severe ischemic heart disease: results of a Phase I open-label dose escalation study. Journal Of The American College Of Cardiology 2000, 36: 2132-2139. PMID: 11127452, DOI: 10.1016/s0735-1097(00)00988-8.Peer-Reviewed Original ResearchMeSH KeywordsAgedExercise TestFeasibility StudiesFemaleFibroblast Growth Factor 2HumansInfusions, Intra-ArterialMagnetic Resonance ImagingMaleMiddle AgedMyocardial IschemiaConceptsIntracoronary basic fibroblast growth factorOpen-label dose-escalation studyDose-escalation studyIschemic heart diseaseBasic fibroblast growth factorFibroblast growth factorHeart diseaseGrowth factorPhase I open-label dose-escalation studyFGF-2Non-Q-wave myocardial infarctionSevere ischemic heart diseaseSeattle Angina QuestionnaireTreadmill exercise testingQuality of lifeRegional wall thickeningMagnetic resonance imagingRFGF-2Angina QuestionnaireExercise toleranceRetinal examinationEscalation studyExercise testingIntracoronary administrationLaboratory parametersClinical Trials in Coronary Angiogenesis: Issues, Problems, Consensus
Simons M, Bonow R, Chronos N, Cohen D, Giordano F, Hammond H, Laham R, Li W, Pike M, Sellke F, Stegmann T, Udelson J, Rosengart T. Clinical Trials in Coronary Angiogenesis: Issues, Problems, Consensus. Circulation 2000, 102: e73-86. PMID: 10982554, DOI: 10.1161/01.cir.102.11.e73.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis Inducing AgentsAnimalsClinical Trials as TopicCoronary AngiographyCoronary VesselsEndothelial Growth FactorsFibroblast Growth Factor 2Genetic TherapyHeart DiseasesHumansLymphokinesMagnetic Resonance ImagingNeovascularization, PhysiologicPatient SelectionTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsClinical trialsCoronary angiogenesisAdvanced ischemic heart diseaseAngiogenic growth factor therapySide effect profileIschemic heart diseaseGrowth factor therapyAppropriate patient populationAmerican Heart AssociationNew treatment strategiesTherapeutic end pointRoute of administrationBiology of angiogenesisNew blood supplyFactor therapyCoronary diseaseEffect profilePatient populationHeart AssociationHeart diseaseTreatment strategiesBlood supplyTherapeutic strategiesPreclinical investigationsTherapeutic angiogenesis
1995
Magnetic resonance mapping demonstrates benefits of VEGF–induced myocardial angiogenesis
Pearlman J, Hibberd M, Chuang M, Harada K, Lopez J, Gladstone S, Friedman M, Sellke F, Simons M. Magnetic resonance mapping demonstrates benefits of VEGF–induced myocardial angiogenesis. Nature Medicine 1995, 1: 1085-1089. PMID: 7489368, DOI: 10.1038/nm1095-1085.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorMagnetic resonance imagingBlood supplyCoronary occlusive diseasePlacebo-controlled studyCollateral blood supplyBetter ejection fractionCoronary artery occlusionCause of deathCollateral vessel developmentEndothelial growth factorRegional wall thickeningArtery occlusionOcclusive diseaseEjection fractionCollateral vesselsCoronary arteryCollateral developmentIschemic zoneVEGF infusionMyocardial angiogenesisResonance imagingWall thickeningHeart attackPorcine model
1992
Assessment of relative sensitivities of noninvasive tests for cardiac amyloidosis in documented cardiac amyloidosis
Simons M, Isner J. Assessment of relative sensitivities of noninvasive tests for cardiac amyloidosis in documented cardiac amyloidosis. The American Journal Of Cardiology 1992, 69: 425-427. PMID: 1734663, DOI: 10.1016/0002-9149(92)90250-3.Peer-Reviewed Original Research