2014
Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium
Chen PY, Qin L, Tellides G, Simons M. Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium. Science Signaling 2014, 7: ra90. PMID: 25249657, DOI: 10.1126/scisignal.2005504.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell TransdifferentiationCoronary VesselsEndothelium, VascularExtracellular MatrixFibroblastsGraft RejectionHeart TransplantationHeterograftsHindlimbHuman Umbilical Vein Endothelial CellsHumansIschemiaMesodermMiceMice, Mutant StrainsMicroRNAsMuscle, Smooth, VascularNeointimaReceptor, Fibroblast Growth Factor, Type 1Receptors, Fibroblast Growth FactorSignal TransductionSmad2 ProteinTransforming Growth Factor betaTransplantation ChimeraConceptsFibroblast growth factor receptor 1Growth factor receptor 1Factor receptor 1Extracellular matrixSmooth muscle cellsMuscle cellsEndothelial cell-specific knockoutKey regulatorReceptor 1TGFβ signalingCell-specific knockoutDecreased abundanceMesenchymal transitionKey inhibitorVascular homeostasisGrowth factorDevelopment of EndMTRecurrence of stenosisTGFβGrowth of neointimaCellsNeointima formationEndMTVascular lumenSignaling
1997
c‐Myb function in fibroblasts
Bein K, Husain M, Ware J, Mucenski M, Rosenberg R, Simons M. c‐Myb function in fibroblasts. Journal Of Cellular Physiology 1997, 173: 319-326. PMID: 9369944, DOI: 10.1002/(sici)1097-4652(199712)173:3<319::aid-jcp3>3.0.co;2-q.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAnimalsCalciumCell CycleCells, CulturedCytoplasmDNA-Binding ProteinsDrosophilaEmbryo, MammalianEmbryo, NonmammalianFibroblastsHeterozygoteHomeodomain ProteinsMiceMice, KnockoutProto-Oncogene ProteinsProto-Oncogene Proteins c-mybRecombinant Fusion ProteinsTrans-ActivatorsTranscription FactorsTranscription, GeneticTransfectionConceptsC-Myb proteinDominant-negative constructMyb DNA binding domainC-MybMYB family membersDNA binding domainsNegative constructsCell cycle regulationSignificant sequence homologyC-myb geneMouse embryonic fibroblastsC-Myb functionCell cycle progressionCell type expressionProtooncogene c-mybNIH 3T3 fibroblastsCell cycle arrestG1 cell cycle arrestNuclear transcription factorA-mybCycle regulationIntracellular calcium levelsB-MybTranscription factorsCDNA sequence