1997
Rat arterial wall retains myointimal hyperplastic potential long after arterial injury.
Sirois M, Simons M, Kuter D, Rosenberg R, Edelman E. Rat arterial wall retains myointimal hyperplastic potential long after arterial injury. Circulation 1997, 96: 1291-8. PMID: 9286961, DOI: 10.1161/01.cir.96.4.1291.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsVascular diseaseNeointimal hyperplasiaMuscle cellsMedial smooth muscle cellsBlood vesselsAccelerated vascular diseaseSingle-dose therapyPDGFR-beta expressionVascular smooth muscle cellsPlatelet-derived growth factorProliferative vascular diseasesPeriod of thrombocytopeniaArterial injuryEndothelial denudationVascular injuryPlatelet depletionIntimal hyperplasiaPharmacological modalitiesVascular healingArterial wallHyperplasiaGrowth factorNative vesselsInjury
1996
Antisense Approach to Restenosis
Simons M. Antisense Approach to Restenosis. Circulation Journal 1996, 60: 1. PMID: 8648878, DOI: 10.1253/jcj.60.1.Peer-Reviewed Original Research
1993
Relation between Activated Smooth-Muscle Cells in Coronary-Artery Lesions and Restenosis after Atherectomy
Simons M, Leclerc G, Safian R, Isner J, Weir L, Baim D. Relation between Activated Smooth-Muscle Cells in Coronary-Artery Lesions and Restenosis after Atherectomy. New England Journal Of Medicine 1993, 328: 608-613. PMID: 8429852, DOI: 10.1056/nejm199303043280903.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsMyosin heavy chainNonmuscle myosin heavy chainRecurrent luminal narrowingCoronary artery lesionsExercise thallium scintigraphyVascular smooth muscle cellsCoronary atherosclerotic plaquesPresence of restenosisHigh-power fieldGroup of lesionsNegative resultsAngiographic followCoronary atherectomyCoronary angioplastyThallium scintigraphyCoronary lesionsLuminal narrowingNeointimal proliferationSubsequent restenosisLate lossLuminal diameterHeavy chainHigh riskAtherectomy