2023
Dexmedetomidine improves pulmonary outcomes in thoracic surgery under one-lung ventilation: A meta-analysis
Zorrilla-Vaca A, Grant M, Law M, Messinger C, Pelosi P, Varelmann D. Dexmedetomidine improves pulmonary outcomes in thoracic surgery under one-lung ventilation: A meta-analysis. Journal Of Clinical Anesthesia 2023, 93: 111345. PMID: 37988813, PMCID: PMC11034816, DOI: 10.1016/j.jclinane.2023.111345.Peer-Reviewed Original ResearchAcute respiratory distress syndromePostoperative pulmonary complicationsOne-lung ventilationThoracic surgeryDexmedetomidine groupPlacebo groupPostoperative atelectasisRandomized trialsOdds ratioIncidence of PPCsImpact of dexmedetomidineIntraoperative respiratory mechanicsPostoperative lung functionRespiratory distress syndromeML/cmHRandom-effects modelPostoperative pneumoniaPulmonary complicationsPulmonary outcomesIntrapulmonary shuntPostoperative FEV1Secondary outcomesDistress syndromeLung functionPrimary outcome
2022
Individualised positive end-expiratory pressure in abdominal surgery: a systematic review and meta-analysis
Zorrilla-Vaca A, Grant M, Urman R, Frendl G. Individualised positive end-expiratory pressure in abdominal surgery: a systematic review and meta-analysis. British Journal Of Anaesthesia 2022, 129: 815-825. PMID: 36031417, DOI: 10.1016/j.bja.2022.07.009.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureEnd-expiratory pressurePulmonary complicationsAbdominal surgerySystemic inflammationRisk ratioAcute respiratory distress syndromeLaird random-effects modelOverall pulmonary complicationsPostoperative pulmonary outcomesComposite primary outcomeEnd of surgerySystemic inflammatory markersRespiratory distress syndromeConfidence intervalsRandom-effects modelPostoperative atelectasisPrimary endpointPulmonary outcomesCochrane riskInflammatory markersLung injuryPostoperative hypoxaemiaSecondary outcomesBias tool
2017
Relation between bispectral index measurements of anesthetic depth and postoperative mortality: a meta-analysis of observational studies
Zorrilla-Vaca A, Healy R, Wu C, Grant M. Relation between bispectral index measurements of anesthetic depth and postoperative mortality: a meta-analysis of observational studies. Journal Canadien D'anesthésie 2017, 64: 597-607. PMID: 28361391, DOI: 10.1007/s12630-017-0872-6.Peer-Reviewed Original ResearchConceptsDepth of anesthesiaLow bispectral indexObservational studyBispectral indexSubgroup analysisSignificant associationResultsEight observational studiesLong-term mortalityPooled effect sizeMain electronic databasesBispectral index measurementsRandom-effects modelPostoperative mortalityHazard ratioIntroductionThe associationRandomized trialsInclusion criteriaAnesthesiaElectronic databasesNarrative reviewPotential associationAnesthetic depthMethodsThe literatureMortalityAnesthesia depth
2016
The Impact of Neuraxial Versus General Anesthesia on the Incidence of Postoperative Surgical Site Infections Following Knee or Hip Arthroplasty
Zorrilla-Vaca A, Grant MC, Mathur V, Li J, Wu CL. The Impact of Neuraxial Versus General Anesthesia on the Incidence of Postoperative Surgical Site Infections Following Knee or Hip Arthroplasty. Regional Anesthesia & Pain Medicine 2016, 41: 555-563. PMID: 27380106, DOI: 10.1097/aap.0000000000000437.Peer-Reviewed Original ResearchConceptsPostoperative surgical site infectionSurgical site infectionKnee arthroplastyHip arthroplastySite infectionNeuraxial anesthesiaGeneral anesthesiaSubgroup analysisOdds ratioDevelopment of SSIPooled unadjusted odds ratioUnadjusted odds ratioLarge observational trialsRandom-effects modelOverall beneficial effectObservational trialAnesthetic techniqueAnesthesia techniquesJoint arthroplastyInclusion criteriaTrial designArthroplastyMeta-AnalysisAnesthesiaPotential association