Treatment of Excessive Polycythemia of High Altitude with Respiratory Stimulant Drugs1–3
Kryger M, McCullough R, Collins D, Scoggin C, Weil J, Grover R. Treatment of Excessive Polycythemia of High Altitude with Respiratory Stimulant Drugs1–3. American Journal Of Respiratory And Critical Care Medicine 1978, 117: 455-64. PMID: 629480, DOI: 10.1164/arrd.1978.117.3.455.Peer-Reviewed Original ResearchConceptsMedroxyprogesterone acetateExcessive polycythemiaTidal volumeVentilatory responseArterial PCO2O2 saturationWeeks of therapyMonths of treatmentEffect of medroxyprogesteroneHypoxic ventilatory responseArterial O2 saturationNormal arterial PCO2Progestational agentsArterial PO2Normal lungStimulant effectsExcessive hypoxemiaPatientsMedroxyprogesteroneNormal valuesPolycythemiaDead spaceVentilationTherapyHematocritImpaired Oxygenation During Sleep in Excessive Polycythemia of High Altitude: Improvement with Respiratory Stimulation
Kryger M, Glas R, Jackson D, McCullough R, Scoggin C, Grover R, Weil J. Impaired Oxygenation During Sleep in Excessive Polycythemia of High Altitude: Improvement with Respiratory Stimulation. Sleep 1978, 1: 3-17. PMID: 756057, DOI: 10.1093/sleep/1.1.3.Peer-Reviewed Original ResearchConceptsMedroxyprogesterone acetatePolycythemic patientsSevere hypoxemiaExcessive polycythemiaDouble-blind crossover trialMean lowest SaO2REM stage sleepDegree of hypoxemiaHigh-altitude residentsAwake SaO2Nocturnal SaO2Sleep hypoxemiaStage sleepImpaired oxygenationCrossover trialMean SaO2Lowest SaO2Control subjectsHypoxemiaTherapeutic effectOxygen saturationExcessive hypoxemiaSaO2Breathing patternPatients