1983
The role of protriptyline in obstructive sleep apnea.
Brownell L, Perez-Padilla R, West P, Kryger M. The role of protriptyline in obstructive sleep apnea. European Respiratory Journal 1983, 19: 621-4. PMID: 6360257.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaTreatment of mildLong-term treatmentTricyclic agentsObese patientsObstructive apneaClinical statusCrossover trialImproved oxygenationInvasive treatmentTerm treatmentPatientsApneaArousal frequencySomnolenceProtriptylineTreatmentTrialsOxygenationREMTherapyMildMonths
1982
Protriptyline in Obstructive Sleep Apnea — A Double-Blind Trial
Brownell L, West P, Sweatman P, Acres J, Kryger M. Protriptyline in Obstructive Sleep Apnea — A Double-Blind Trial. New England Journal Of Medicine 1982, 307: 1037-1042. PMID: 6750396, DOI: 10.1056/nejm198210213071701.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaTotal sleep timeApnea timeApnea durationBody weightSleep timeDouble-blind crossover studyDouble-blind trialMonths of treatmentWeeks of treatmentNocturnal oxygenationREM reductionDaytime somnolenceCrossover studyTricyclic antidepressantsApneaArousal frequencySimilar decreaseProtriptylineSimilar improvementsTreatmentOxygenationDurationSomnolence
1980
Sleep apnea in acromegaly
Mezon B, West P, Maclean J, Kryger M. Sleep apnea in acromegaly. The American Journal Of Medicine 1980, 69: 615-623. PMID: 7424949, DOI: 10.1016/0002-9343(80)90477-5.Peer-Reviewed Original ResearchConceptsUpper airway obstructionSleep apnea syndromeAirway obstructionApnea syndromeSomnolent patientsSevere hypoxemiaPharyngeal airwayUpper airwayNormal sleepLarge tonguePatientsAcromegalyObstructionAirwaySyndromeSleepPeriodic obstructionTongueHypoxemiaSomnolenceTracheostomyApneaEndoscopyLarynxPharynx
1974
The sleep deprivation syndrome of the obese patient A problem of periodic nocturnal upper airway obstruction
Kryger M, Quesney L, Holder D, Gloor P, MacLeod P. The sleep deprivation syndrome of the obese patient A problem of periodic nocturnal upper airway obstruction. The American Journal Of Medicine 1974, 56: 531-539. PMID: 4818419, DOI: 10.1016/0002-9343(74)90485-9.Peer-Reviewed Original ResearchConceptsUpper airway obstructionSleep deprivation syndromeAirway obstructionUrinary incontinenceDeprivation syndromeNocturnal upper airway obstructionObese menObese patientsPickwickian syndromeUpper airwayVentilatory responseSyndromeObstructionFat depositionArousal patternsIncontinenceSomnolenceBradycardiaSuch findingsTracheostomyAirwayPatientsPathophysiologySleep