2018
Flow limitation/obstruction with recovery breath (FLOW) event for improved scoring of mild obstructive sleep apnea without electroencephalography
Johnson KG, Johnson DC, Thomas RJ, Feldmann E, Lindenauer PK, Visintainer P, Kryger MH. Flow limitation/obstruction with recovery breath (FLOW) event for improved scoring of mild obstructive sleep apnea without electroencephalography. Sleep Medicine 2018, 67: 249-255. PMID: 30583916, PMCID: PMC6548700, DOI: 10.1016/j.sleep.2018.11.014.Peer-Reviewed Original ResearchConceptsApnea/hypopnea indexObstructive sleep apneaMild obstructive sleep apneaSleep apneaAirflow disruptionIntraclass correlationAHI categoriesBaseline PSGHypopnea indexOSA patientsHighest tertileOSA categoriesArousal criteriaPatientsFlow limitationApneaDesaturationFlow scoreArousal eventsOverall kappaObstructionTraining periodHigher proportionElectroencephalographyScoring0479 Novel Flow Limitation/Obstruction With Recovery Breath (FLOW) Event Identifies Obstructive Burden In Mild Obstructive Sleep Apnea
Johnson K, Johnson D, Visintainer P, Kryger M, Thomas R, Linderauer P, Feldmann E. 0479 Novel Flow Limitation/Obstruction With Recovery Breath (FLOW) Event Identifies Obstructive Burden In Mild Obstructive Sleep Apnea. Sleep 2018, 41: a181-a181. DOI: 10.1093/sleep/zsy061.478.Peer-Reviewed Original ResearchMild obstructive sleep apneaObstructive sleep apneaHome sleep apnea testingRespiratory-related arousalsObstructive eventsSleep apneaMild OSA patientsApnea-hypopnea indexIdentification of patientsSleep apnea testingSeverity of diseaseFlow scoreOSA patientsApnea testingAdverse outcomesMild patientsPolysomnography studiesClinical significancePatientsSignificant gender differencesApneaDesaturationAirflow disruptionObstructionArousal data
1982
Central Apnea
Kryger M. Central Apnea. JAMA Internal Medicine 1982, 142: 1793-1794. PMID: 7125764, DOI: 10.1001/archinte.1982.00340230033005.Peer-Reviewed Original ResearchConceptsCentral apneaObstructive apneaSleep apneaMixed apneaSevere gas exchange abnormalitiesBrain stem diseaseCentral sleep apneaGas exchange abnormalitiesRespiratory muscle contractionAdult patientsAnatomic obstructionUpper airwayBrain stemPhysiologic findingsApneaPatientsMuscle contractionHypoventilationDiseaseVast majorityAirwayObstructionAbnormalitiesSleep
1981
Sleep Disorders in Chronic Airflow Obstruction
Fleetham J, Kryger M. Sleep Disorders in Chronic Airflow Obstruction. Medical Clinics Of North America 1981, 65: 549-561. PMID: 7017303, DOI: 10.1016/s0025-7125(16)31513-9.Peer-Reviewed Original ResearchConceptsChronic airflow obstructionAirflow obstructionPulmonary hypertensionCardiac arrhythmiasLess rapid eye movement sleepRapid eye movement (REM) sleepSecondary pulmonary hypertensionNocturnal oxygen therapyGas exchange abnormalitiesSleep apnea syndromeEye movement sleepSleep stage changesApnea syndromeOxygen therapyPhysiologic disturbancesMovement sleepSleep disordersSleep profilesPatientsObstructionSleepHypertensionArrhythmiasStage changesSyndrome
1980
Sleep apnea in acromegaly
Mezon B, West P, Maclean J, Kryger M. Sleep apnea in acromegaly. The American Journal Of Medicine 1980, 69: 615-623. PMID: 7424949, DOI: 10.1016/0002-9343(80)90477-5.Peer-Reviewed Original ResearchConceptsUpper airway obstructionSleep apnea syndromeAirway obstructionApnea syndromeSomnolent patientsSevere hypoxemiaPharyngeal airwayUpper airwayNormal sleepLarge tonguePatientsAcromegalyObstructionAirwaySyndromeSleepPeriodic obstructionTongueHypoxemiaSomnolenceTracheostomyApneaEndoscopyLarynxPharynx
1976
Diagnosis of obstruction of the upper and central airways
Kryger M, Bode F, Antic R, Anthonisen N. Diagnosis of obstruction of the upper and central airways. The American Journal Of Medicine 1976, 61: 85-93. PMID: 779469, DOI: 10.1016/0002-9343(76)90048-6.Peer-Reviewed Original ResearchMeSH KeywordsAirway ObstructionAirway ResistanceApneaBronchiectasisDiagnosis, DifferentialFemaleForced Expiratory VolumeHumansMaleMiddle AgedObesityPulmonary Heart DiseasePulmonary VentilationRadiographyResidual VolumeRespiratory System AbnormalitiesSleep Wake DisordersTracheal DiseasesTracheal NeoplasmsVital CapacityConceptsUpper airway obstructionAirway obstructionSleep deprivation syndromeFlow-volume loopsDiagnosis of obstructionMethods of diagnosisSuch patientsPhysical examinationUpper airwayCentral airwaysCorrect diagnosisDeprivation syndromePhysiologic testsCharacteristic historyObstructionPatientsDiagnosisAirwayInstructive caseSyndromeSleep
1974
The sleep deprivation syndrome of the obese patient A problem of periodic nocturnal upper airway obstruction
Kryger M, Quesney L, Holder D, Gloor P, MacLeod P. The sleep deprivation syndrome of the obese patient A problem of periodic nocturnal upper airway obstruction. The American Journal Of Medicine 1974, 56: 531-539. PMID: 4818419, DOI: 10.1016/0002-9343(74)90485-9.Peer-Reviewed Original ResearchConceptsUpper airway obstructionSleep deprivation syndromeAirway obstructionUrinary incontinenceDeprivation syndromeNocturnal upper airway obstructionObese menObese patientsPickwickian syndromeUpper airwayVentilatory responseSyndromeObstructionFat depositionArousal patternsIncontinenceSomnolenceBradycardiaSuch findingsTracheostomyAirwayPatientsPathophysiologySleep