2022
Deletion of matrix metalloproteinase-12 compromises mechanical homeostasis and leads to an aged aortic phenotype in young mice
Spronck B, Ramachandra AB, Moriyama L, Toczek J, Han J, Sadeghi MM, Humphrey JD. Deletion of matrix metalloproteinase-12 compromises mechanical homeostasis and leads to an aged aortic phenotype in young mice. Journal Of Biomechanics 2022, 141: 111179. PMID: 35759974, PMCID: PMC9585962, DOI: 10.1016/j.jbiomech.2022.111179.Peer-Reviewed Original ResearchConceptsPulse wave velocityAortic phenotypeYoung miceAortic agingMMP-12Matrix metalloproteinasesMMP-12-deficient miceOld adult miceMatrix metalloproteinase-12Biomechanical propertiesAbdominal aortaArterial agingDeficient miceEnd organsBlood flowAdult miceCentral arteriesPercent changeMetalloproteinase-12MiceArterial wallAortaYoung adultsMatrix turnoverStrong proteolytic activity
2021
Characteristics and outcomes of small abdominal aortic aneurysm rupture in the American College of Surgeons National Surgical Quality Improvement Program database
Bellamkonda K, Nassiri N, Sadeghi MM, Zhang Y, Guzman RJ, Ochoa Chaar CI. Characteristics and outcomes of small abdominal aortic aneurysm rupture in the American College of Surgeons National Surgical Quality Improvement Program database. Journal Of Vascular Surgery 2021, 74: 729-737. PMID: 33617982, DOI: 10.1016/j.jvs.2021.01.063.Peer-Reviewed Original ResearchConceptsEndovascular aneurysm repairRAAA groupElective repairSmall AAAsRAAA repairAAA repairAneurysm repairAmerican CollegeSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement ProgramElective abdominal aortic aneurysm repairNational Surgical Quality Improvement ProgramShorter mean operative timeQuality Improvement Program databaseAbdominal aortic aneurysm repairLower body mass indexSurgical Quality Improvement ProgramImprovement Program databaseMean operative timeAortic aneurysm repairOpen AAA repairBody mass indexMultivariable logistic regressionAbdominal aortic aneurysm rupture
2018
Prevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population
He BJ, Malm BJ, Carino M, Sadeghi MM. Prevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population. Journal Of Nuclear Cardiology 2018, 26: 1688-1693. PMID: 29492838, DOI: 10.1007/s12350-018-1232-9.Peer-Reviewed Original ResearchConceptsIncidental noncardiac findingsMyocardial perfusion imagingNoncardiac findingsPulmonary nodulesIncidental findingActionable incidental findingsVeteran populationOverall interobserver agreementAttenuation correction CTSpecific guidelinesHiatal herniaExtracardiac massPleural plaquesAortic aneurysmPhysician specialtyPerfusion imagingCommon occurringCardiologistsInterobserver agreementInterreader agreementAttenuation artifactsRadiologistsPrevalenceNodulesVeterans
2011
Age-Related Macular Degeneration and Incident Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis
Fernandez AB, Wong TY, Klein R, Collins D, Burke G, Cotch MF, Klein B, Sadeghi MM, Chen J. Age-Related Macular Degeneration and Incident Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis. Ophthalmology 2011, 119: 765-770. PMID: 22197438, PMCID: PMC3314126, DOI: 10.1016/j.ophtha.2011.09.044.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationIncident coronary heart diseaseCoronary heart diseaseEarly age-related macular degenerationRisk of CHDCVD eventsMulti-Ethnic StudyRisk factorsMacular degenerationLate age-related macular degenerationNon-AMD groupCVD risk factorsCardiovascular disease eventsIncident cardiovascular diseaseProspective cohort studyHistory of CVDCox regression modelMulti-ethnic cohortMean followCohort studyRetinal photographsClinical followHeart diseaseCardiovascular diseaseDisease events