2010
Molecular Imaging of Matrix Metalloproteinase Activation to Predict Murine Aneurysm Expansion In Vivo
Razavian M, Zhang J, Nie L, Tavakoli S, Razavian N, Dobrucki LW, Sinusas AJ, Edwards DS, Azure M, Sadeghi MM. Molecular Imaging of Matrix Metalloproteinase Activation to Predict Murine Aneurysm Expansion In Vivo. Journal Of Nuclear Medicine 2010, 51: 1107-1115. PMID: 20554725, PMCID: PMC2908304, DOI: 10.2967/jnumed.110.075259.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoproteins EArteriovenous FistulaAutoradiographyCarotid ArteriesCatalysisDisease ProgressionEnzyme ActivationImmunohistochemistryIndicators and ReagentsMatrix MetalloproteinasesMiceMice, KnockoutRadiopharmaceuticalsReverse Transcriptase Polymerase Chain ReactionSubstrate SpecificityTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonConceptsMatrix metalloproteinase activationMMP activationAneurysm inductionMetalloproteinase activationSPECT/CTCurrent imaging modalitiesPathogenesis of aneurysmsSpecific MMP inhibitorsGroups of animalsMMP tracerMolecular imagingArterial aneurysmsAneurysm expansionFocal uptakeDeficient miceCarotid aneurysmsCarotid arteryApolipoprotein ETracer uptakeAneurysmsMajor causeMMP inhibitorsVessel areaImaging modalitiesWk
2006
The pathobiology of the vessel wall: Implications for imaging
Sadeghi MM. The pathobiology of the vessel wall: Implications for imaging. Journal Of Nuclear Cardiology 2006, 13: 402-414. PMID: 16750785, DOI: 10.1016/j.nuclcard.2006.03.012.Peer-Reviewed Original ResearchConceptsVascular diseaseVessel wallDiagnostic approachMagnetic resonance imaging angiographyDiseased coronary segmentsMolecular imaging targetsNovel therapeutic approachesNovel diagnostic approachCommon vasculopathyCoronary arteryCoronary segmentsTherapeutic approachesAnimal modelsAnimal studiesVascular pathophysiologyVascular imagingMajor causeVessel wall biologyIntravascular imagingDiseaseImaging targetsPathologyAccessible targetsMolecular imagingSingle-modality imaging