2022
Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication
Hsu JC, Laurent-Rolle M, Pawlak JB, Xia H, Kunte A, Hee JS, Lim J, Harris LD, Wood JM, Evans GB, Shi PY, Grove TL, Almo SC, Cresswell P. Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication. Molecular Cell 2022, 82: 1631-1642.e6. PMID: 35316659, PMCID: PMC9081181, DOI: 10.1016/j.molcel.2022.02.031.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsImmunity, InnateOxidoreductases Acting on CH-CH Group DonorsProteinsRibosomesS-AdenosylmethionineVirus ReplicationConceptsInterferon-stimulated genesS-adenosyl methionineTranslation inhibitionRadical S-adenosyl methionineInnate immune responseIntegrated stress response pathwayStress response pathwaysViral RNA translationImmune responseAntiviral responseInnate immunityAntiviral mechanismTranslation regulatorsTranslational repressionViral replicationEnzymatic productDidehydro-CTPResponse pathwaysRNA translationViperinSAM activityPathwayInhibitionBroad spectrumReplication
2019
The Role of NS5 Protein in Determination of Host Cell Range for Yellow Fever Virus
Laurent-Rolle M, Morrison J. The Role of NS5 Protein in Determination of Host Cell Range for Yellow Fever Virus. DNA And Cell Biology 2019, 38: 1414-1417. PMID: 31633391, DOI: 10.1089/dna.2019.5115.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2014
Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKKε Kinase-Mediated Antiviral Response
Rajsbaum R, Versteeg GA, Schmid S, Maestre AM, Belicha-Villanueva A, Martínez-Romero C, Patel JR, Morrison J, Pisanelli G, Miorin L, Laurent-Rolle M, Moulton HM, Stein DA, Fernandez-Sesma A, tenOever BR, García-Sastre A. Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKKε Kinase-Mediated Antiviral Response. Immunity 2014, 40: 880-895. PMID: 24882218, PMCID: PMC4114019, DOI: 10.1016/j.immuni.2014.04.018.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntiviral AgentsCells, CulturedEnzyme ActivationHumansI-kappa B KinaseInterferon Type IJanus Kinase 1MicePhosphorylationPolyubiquitinRNA InterferenceRNA, Small InterferingSignal TransductionSTAT1 Transcription FactorTripartite Motif ProteinsUbiquitin-Conjugating EnzymesUbiquitin-Protein LigasesConceptsUnanchored K48Polyubiquitin chainsUnanchored polyubiquitin chainsUpregulation of hundredsAntiviral responseIκB kinase epsilonTripartite motif (TRIM) familyIKKε activationMotif familyKinase activationCellular factorsUBE2KReceptor signalingSTAT1 phosphorylationK48Kinase epsilonType I interferonIFN signalingIFN receptor signalingTRIM6Microbial infectionsISG inductionI interferonSignalingIKKε