2020
Coronavirus Disease 2019 in Solid Organ Transplant: A Multicenter Cohort Study
Kates OS, Haydel BM, Florman SS, Rana MM, Chaudhry ZS, Ramesh MS, Safa K, Kotton CN, Blumberg EA, Besharatian BD, Tanna SD, Ison MG, Malinis M, Azar MM, Rakita RM, Morilla JA, Majeed A, Sait AS, Spaggiari M, Hemmige V, Mehta SA, Neumann H, Badami A, Goldman JD, Lala A, Hemmersbach-Miller M, McCort ME, Bajrovic V, Ortiz-Bautista C, Friedman-Moraco R, Sehgal S, Lease ED, Fisher CE, Limaye AP, Arya A, Jeng A, Kuo A, Luk A, Puing A, Rossi A, Brueckner A, Multani A, Keller B, Derringer D, Florescu D, Dominguez E, Sandoval E, Bilgili E, Hashim F, Silveira F, Haidar G, Joharji H, Murad H, Gani I, el-amm J, Kahwaji J, Popoola J, Yabu J, Hughes K, Saharia K, Gajurel K, Bowman L, Veroux M, Morales M, Fung M, Theodoropoulos N, de la Cruz O, Kapoor R, La Hoz R, Allam S, Vora S, McCarty T, Anderson-Haag T, Malhotra U, Kelly U, Bhandaram V, Bennett W, Lominadze Z. Coronavirus Disease 2019 in Solid Organ Transplant: A Multicenter Cohort Study. Clinical Infectious Diseases 2020, 73: e4090-e4099. PMID: 32766815, PMCID: PMC7454362, DOI: 10.1093/cid/ciaa1097.Peer-Reviewed Original ResearchConceptsSOT recipientsUnderlying comorbiditiesCohort studyLaboratory-confirmed COVID-19Solid organ transplant recipientsMulti-center cohort studyCOVID-19Multicenter cohort studyOrgan transplant recipientsPredictors of mortalitySolid organ transplantsMultivariable logistic regressionKidney/pancreasCoronavirus disease 2019 (COVID-19) pandemicElectronic case report formCase report formsDisease 2019 pandemicImmunosuppression intensityStandardized intakePrimary endpointTransplant recipientsHospitalized patientsMedian ageTransplant centersClinical featuresTocilizumab Treatment for Cytokine Release Syndrome in Hospitalized Patients With Coronavirus Disease 2019 Survival and Clinical Outcomes
Price CC, Altice FL, Shyr Y, Koff A, Pischel L, Goshua G, Azar MM, Mcmanus D, Chen SC, Gleeson SE, Britto CJ, Azmy V, Kaman K, Gaston DC, Davis M, Burrello T, Harris Z, Villanueva MS, Aoun-Barakat L, Kang I, Seropian S, Chupp G, Bucala R, Kaminski N, Lee AI, LoRusso PM, Topal JE, Dela Cruz C, Malinis M. Tocilizumab Treatment for Cytokine Release Syndrome in Hospitalized Patients With Coronavirus Disease 2019 Survival and Clinical Outcomes. CHEST Journal 2020, 158: 1397-1408. PMID: 32553536, PMCID: PMC7831876, DOI: 10.1016/j.chest.2020.06.006.Peer-Reviewed Original ResearchConceptsCytokine release syndromeTocilizumab-treated patientsSevere diseaseRelease syndromeTocilizumab treatmentInflammatory biomarkersNonsevere diseaseSoluble IL-2 receptor levelsHigh-sensitivity C-reactive proteinIL-2 receptor levelsConsecutive COVID-19 patientsIL-6 receptor antagonistMechanical ventilation outcomesC-reactive proteinCOVID-19 patientsHigher admission levelsRace/ethnicityMV daysVentilation outcomesAdverse eventsChart reviewClinical responseMedian ageWhite patientsClinical outcomes
2017
Graft loss among renal-transplant recipients with early reduction of immunosuppression for BK viremia
Azar MM, Assi R, Valika AK, Banach DB, Hall IE, Landry ML, Malinis MF. Graft loss among renal-transplant recipients with early reduction of immunosuppression for BK viremia. World Journal Of Transplantation 2017, 7: 269-275. PMID: 29104861, PMCID: PMC5661124, DOI: 10.5500/wjt.v7.i5.269.Peer-Reviewed Original ResearchRenal transplant recipientsGraft lossBK viremiaImmunosuppression reductionAcute rejectionEarly reductionTransplant recipientsPolymerase chain reactionCopies/Death-censored graft lossDeceased donor kidney transplantationKidney transplant recipientsDonor kidney transplantationRenal transplant biopsiesCopies/mLQuantitative polymerase chain reactionGraft functionKidney transplantationTransplant biopsiesMedian ageMonths 1PyVANBKV DNALower incidenceRetrospective analysis