2000
Autoantibody Responses and Pathology Regulated by B7-1 and B7-2 Costimulation in MRL/lpr Lupus
Liang B, Kashgarian M, Sharpe A, Mamula M. Autoantibody Responses and Pathology Regulated by B7-1 and B7-2 Costimulation in MRL/lpr Lupus. The Journal Of Immunology 2000, 165: 3436-3443. PMID: 10975864, DOI: 10.4049/jimmunol.165.6.3436.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAntigens, CDAntigens, Differentiation, B-LymphocyteAutoantibodiesB7-1 AntigenB7-2 AntigenBiomarkersComplement C3DNAImmunoglobulin GImmunoglobulin IsotypesImmunoglobulin MKidneyLupus NephritisLymphocyte ActivationMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred MRL lprMice, KnockoutRibonucleoproteins, Small NuclearT-LymphocytesConceptsMRL-lpr/lpr miceSystemic lupus erythematosusLpr miceB7-2 costimulationB7-1Autoantibody responseB7-2Murine modelCostimulatory signalsAnti-small nuclear ribonucleoproteinMRL/lpr lupusHuman systemic lupus erythematosusB7-1/B7C3 complement depositionAnti-DNA titersAnti-DNA autoantibodiesWild-type animalsImmunotherapeutic interventionsMemory CD4Lupus erythematosusAutoimmune diseasesAutoimmune pathologyC3 depositsComplement depositionT lymphocytes
1992
Anti-Ro autoantibody with cross-reactive binding to the heavy chain of immunoglobulin G.
Mamula M, Harley J. Anti-Ro autoantibody with cross-reactive binding to the heavy chain of immunoglobulin G. The Yale Journal Of Biology And Medicine 1992, 65: 277-87. PMID: 1290272, PMCID: PMC2589586.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAutoantigensBinding, CompetitiveCattleCross ReactionsCyanogen BromideEnzyme-Linked Immunosorbent AssayHumansImmunoglobulin Fab FragmentsImmunoglobulin Fc FragmentsImmunoglobulin GImmunoglobulin Heavy ChainsLupus Erythematosus, SystemicPeptide FragmentsPrecipitin TestsRabbitsRibonucleoproteinsRNA, Small CytoplasmicConceptsSystemic lupus erythematosusRo antibodiesAutoimmune diseasesCross-reactive bindingSera of patientsAnti-Ro autoantibodiesHeavy chainAnti-Ro seraFragments of IgGRo proteinLupus erythematosusCyanogen bromide digestion fragmentsAntigenic stimulusRo seraPatient seraAutoantibodiesIgGFine specificityImmunologic determinantsRo responseImmunoglobulin GSerumAntibodiesRo particleRabbit serum
1991
Importance of the immune response to the Ro/La particle in the development of congenital heart block and neonatal lupus erythematosus.
Silverman E, Mamula M, Hardin J, Laxer R. Importance of the immune response to the Ro/La particle in the development of congenital heart block and neonatal lupus erythematosus. The Journal Of Rheumatology 1991, 18: 120-4. PMID: 2023181.Peer-Reviewed Original ResearchConceptsNeonatal lupus erythematosusCongenital heart blockAnti-La antibodiesHeart blockImmune responseLupus erythematosusCutaneous neonatal lupus erythematosusAnti-U1RNP antibodiesAnti-Ro antibodiesRo antibodiesAnti-RoLa antibodiesAntibodiesErythematosusAssay techniquesPrevious studiesResponsePatientsInfantsPathogenesisWomen
1989
The Ro ribonucleoprotein particle: Induction of autoantibodies and the detection of Ro RNAs among species
Mamula M, O'Brien C, Harley J, Hardin J. The Ro ribonucleoprotein particle: Induction of autoantibodies and the detection of Ro RNAs among species. Clinical Immunology 1989, 52: 435-446. PMID: 2503280, DOI: 10.1016/0090-1229(89)90158-x.Peer-Reviewed Original ResearchConceptsRo RNAsInduction of autoantibodiesSystemic lupus erythematosusRo particleAnti-Ro autoantibodiesCell linesRabbit cell linesSjogren's syndromeLupus erythematosusHuman autoimmune seraRo seraImmune responseHigh titersAutoantibodiesAutoimmune seraSerumRabbit serumSolid-phase assaysRabbit antibodiesHuman cellsImmunodiffusion studiesSyndromeBovine cell linesTissue extractsPrecipitin line