1999
Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*
Mamula M, Gee R, Elliott J, Sette A, Southwood S, Jones P, Blier P. Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*. Journal Of Biological Chemistry 1999, 274: 22321-22327. PMID: 10428801, DOI: 10.1074/jbc.274.32.22321.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAspartic AcidAutoantibodiesAutoimmunityB-LymphocytesBinding, CompetitiveCytochrome c GroupHistocompatibility Antigens Class IIImmune ToleranceIsomerismLymphocyte ActivationMiceMice, Inbred MRL lprMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularPeptide FragmentsProtein BindingProtein Processing, Post-TranslationalRibonucleoproteins, Small NuclearT-LymphocytesConceptsSystemic lupus erythematosusAutoimmune responseT cell autoimmune responsesHuman systemic lupus erythematosusInitiation of autoimmunityT cell compartmentT cell responsesImmunization of miceFunctioning immune systemLupus erythematosusSelf antigensAutoimmune diseasesImmunologic stimuliC-peptidePeptide autoantigensImmune systemCell responsesForeign pathogensImmunizationCytochrome c peptideMiceCell compartmentPresent studyPeptidesResponse
1991
Importance of the immune response to the Ro/La particle in the development of congenital heart block and neonatal lupus erythematosus.
Silverman E, Mamula M, Hardin J, Laxer R. Importance of the immune response to the Ro/La particle in the development of congenital heart block and neonatal lupus erythematosus. The Journal Of Rheumatology 1991, 18: 120-4. PMID: 2023181.Peer-Reviewed Original ResearchConceptsNeonatal lupus erythematosusCongenital heart blockAnti-La antibodiesHeart blockImmune responseLupus erythematosusCutaneous neonatal lupus erythematosusAnti-U1RNP antibodiesAnti-Ro antibodiesRo antibodiesAnti-RoLa antibodiesAntibodiesErythematosusAssay techniquesPrevious studiesResponsePatientsInfantsPathogenesisWomen
1990
The specificity of human anti-cytochrome c autoantibodies that arise in autoimmune disease.
Mamula M, Jemmerson R, Hardin J. The specificity of human anti-cytochrome c autoantibodies that arise in autoimmune disease. The Journal Of Immunology 1990, 144: 1835-40. PMID: 1689756, DOI: 10.4049/jimmunol.144.5.1835.Peer-Reviewed Original ResearchConceptsC autoantibodiesC antibodyPresence of autoantibodiesConnective tissue diseaseSpecificity of autoantibodiesAntimitochondrial antibodiesAutoantibody responseTissue diseaseAutoimmune diseasesDisease subsetsSm autoantigenPatient seraAutoantibodiesAnimal modelsModel AgAntibodiesDiseaseSpecificityPatientsSLEAutoantigensMicePathologySerumResponse