2000
Autoantibody Responses and Pathology Regulated by B7-1 and B7-2 Costimulation in MRL/lpr Lupus
Liang B, Kashgarian M, Sharpe A, Mamula M. Autoantibody Responses and Pathology Regulated by B7-1 and B7-2 Costimulation in MRL/lpr Lupus. The Journal Of Immunology 2000, 165: 3436-3443. PMID: 10975864, DOI: 10.4049/jimmunol.165.6.3436.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAntigens, CDAntigens, Differentiation, B-LymphocyteAutoantibodiesB7-1 AntigenB7-2 AntigenBiomarkersComplement C3DNAImmunoglobulin GImmunoglobulin IsotypesImmunoglobulin MKidneyLupus NephritisLymphocyte ActivationMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred MRL lprMice, KnockoutRibonucleoproteins, Small NuclearT-LymphocytesConceptsMRL-lpr/lpr miceSystemic lupus erythematosusLpr miceB7-2 costimulationB7-1Autoantibody responseB7-2Murine modelCostimulatory signalsAnti-small nuclear ribonucleoproteinMRL/lpr lupusHuman systemic lupus erythematosusB7-1/B7C3 complement depositionAnti-DNA titersAnti-DNA autoantibodiesWild-type animalsImmunotherapeutic interventionsMemory CD4Lupus erythematosusAutoimmune diseasesAutoimmune pathologyC3 depositsComplement depositionT lymphocytes
1996
B7 costimulation and autoantigen specificity enable B cells to activate autoreactive T cells.
Roth R, Nakamura T, Mamula M. B7 costimulation and autoantigen specificity enable B cells to activate autoreactive T cells. The Journal Of Immunology 1996, 157: 2924-31. PMID: 8816398, DOI: 10.4049/jimmunol.157.7.2924.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAntibodies, MonoclonalAntigen PresentationAntigens, CDAutoantigensAutoimmunityB7-1 AntigenB7-2 AntigenBase SequenceB-LymphocytesCell MovementCytochrome c GroupCytokinesFemaleGene Expression RegulationImmunizationLymph NodesLymphocyte ActivationMembrane GlycoproteinsMiceMolecular Sequence DataPeptide FragmentsPolymerase Chain ReactionRatsRNA, MessengerSelf ToleranceSignal TransductionT-Lymphocyte SubsetsConceptsAutoreactive T cellsT cell responsesT cellsB cellsIL-4IL-5Self-AgImmunized B-cell-deficient miceCell responsesAutoimmune T cell responsesB cell-deficient miceB7-1 costimulatory moleculeT cell autoimmunityCell-deficient miceTreatment of miceT cell toleranceNaive T cellsCytokine mRNA responsesCell autoimmunityB7 costimulationCostimulatory moleculesAutoantigen specificityB7-2Cytokine mRNAIFN-gamma