2021
A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice
Mao T, Israelow B, Lucas C, Vogels CBF, Gomez-Calvo ML, Fedorova O, Breban MI, Menasche BL, Dong H, Linehan M, Alpert T, Anderson F, Earnest R, Fauver J, Kalinich C, Munyenyembe K, Ott I, Petrone M, Rothman J, Watkins A, Wilen C, Landry M, Grubaugh N, Pyle A, Iwasaki A. A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice. Journal Of Experimental Medicine 2021, 219: e20211818. PMID: 34757384, PMCID: PMC8590200, DOI: 10.1084/jem.20211818.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionChronic SARS-CoV-2 infectionVariants of concernLethal SARS-CoV-2 infectionPost-infection therapyLower respiratory tractPost-exposure treatmentType I interferonSARS-CoV-2Effective medical countermeasuresAdaptive immune systemBroad-spectrum antiviralsContext of infectionSingle doseRespiratory tractViral controlImmunodeficient miceSevere diseaseMouse modelI interferonViral infectionImmune systemInnate immunityDisease preventionConsiderable efficacy
2017
Antiviral Response in the Nasopharynx Identifies Patients With Respiratory Virus Infection
Landry ML, Foxman EF. Antiviral Response in the Nasopharynx Identifies Patients With Respiratory Virus Infection. The Journal Of Infectious Diseases 2017, 217: 897-905. PMID: 29281100, PMCID: PMC5853594, DOI: 10.1093/infdis/jix648.Peer-Reviewed Original ResearchConceptsRespiratory virusesNasopharyngeal swabsViral infectionCXCL10 protein levelsPatient nasopharyngeal swabsRespiratory virus infectionsHuman nasal epithelial cellsManagement of patientsRespiratory virus detectionNasal epithelial cellsSingle host proteinVirus detectionSimple diagnostic testIdentifies patientsRespiratory symptomsRespiratory infectionsRespiratory illnessHigh burdenVirus infectionReceptor RIGCost-effective testAntiviral responseAccurate diagnosisDiagnostic testsInfectionFatal case of cutaneous‐sparing orolaryngeal zoster in a renal transplant recipient
Helou E, Grant M, Landry M, Wu X, Morrow JS, Malinis MF. Fatal case of cutaneous‐sparing orolaryngeal zoster in a renal transplant recipient. Transplant Infectious Disease 2017, 19 PMID: 28401625, DOI: 10.1111/tid.12704.Peer-Reviewed Case Reports and Technical NotesConceptsTransplant recipientsHerpes zosterSolid organ transplant recipientsCTLA-4 inhibitorsKidney transplant recipientsRenal transplant recipientsOrgan transplant recipientsAcute rejectionSOT recipientsMucosal lesionsMeningo-encephalitisPoor outcomeFatal casesHerpesvirus infectionSignificant causeRecipientsZosterPneumonitisMorbidityPatientsLesionsInfectionMortalityCases
2005
Herpes simplex virus Type 2 Acute Retinal Necrosis 9 Years after Neonatal Herpes
Landry ML, Mullangi P, Nee P, Klein BR. Herpes simplex virus Type 2 Acute Retinal Necrosis 9 Years after Neonatal Herpes. The Journal Of Pediatrics 2005, 146: 836-838. PMID: 15973328, DOI: 10.1016/j.jpeds.2005.02.025.Peer-Reviewed Original Research
2000
A Standardized Plaque Reduction Assay for Determination of Drug Susceptibilities of Cytomegalovirus Clinical Isolates
Landry M, Stanat S, Biron K, Brambilla D, Britt W, Jokela J, Chou S, Drew W, Erice A, Gilliam B, Lurain N, Manischewitz J, Miner R, Nokta M, Reichelderfer P, Spector S, Weinberg A, Yen-Lieberman B, Crumpacker C, Group T. A Standardized Plaque Reduction Assay for Determination of Drug Susceptibilities of Cytomegalovirus Clinical Isolates. Antimicrobial Agents And Chemotherapy 2000, 44: 688-692. PMID: 10681339, PMCID: PMC89747, DOI: 10.1128/aac.44.3.688-692.2000.Peer-Reviewed Original Research
1991
Antiviral Activity of 5-Iodo-2’-Deoxyuridine and Related Drugs in Human Keratinocytes Infected in vitro with Herpes simplex Virus Type 1
Reuveni H, Bull CO, Landry ML, Milstone LM, Schwartz PM. Antiviral Activity of 5-Iodo-2’-Deoxyuridine and Related Drugs in Human Keratinocytes Infected in vitro with Herpes simplex Virus Type 1. Skin Pharmacology And Physiology 1991, 4: 291-297. PMID: 1665069, DOI: 10.1159/000210964.Peer-Reviewed Original ResearchConceptsGuinea pig embryo cellsHerpes simplex virus type 1Simplex virus type 1Virus type 1Antiviral activityThymidine phosphorylaseHuman keratinocytesType 1Cutaneous viral infectionsTopical antiviral agentsAntiviral agentsViral infectionExperimental animalsEmbryo cellsRelated drugsIUdRInfected cellsKeratinocytesDrugsCellsActivityInfectionPhosphorylase
1989
Rapid and accurate viral diagnosis
Landry ML, Mayo DR, Hsiung GD. Rapid and accurate viral diagnosis. Pharmacology & Therapeutics 1989, 40: 287-328. PMID: 2499895, PMCID: PMC7133644, DOI: 10.1016/0163-7258(89)90098-3.Peer-Reviewed Original Research
1987
Effect of 2'-fluoro-5-methyl-ara-uracil and cyclophosphamide on herpes simplex virus infection in guinea pigs.
Zheng ZM, Landry ML, Mayo DR, Hsiung GD. Effect of 2'-fluoro-5-methyl-ara-uracil and cyclophosphamide on herpes simplex virus infection in guinea pigs. Acta Pharmacologica Sinica 1987, 8: 158-63. PMID: 2959004.Peer-Reviewed Original Research
1982
Effect of acyclovir on genital infection with herpes simplex virus types 1 and 2 in the guinea pig
Landry M, Lucia H, Hsiung GD, Pronovost A, Dann P, August M, Mayo D. Effect of acyclovir on genital infection with herpes simplex virus types 1 and 2 in the guinea pig. The American Journal Of Medicine 1982, 73: 143-150. PMID: 6285705, DOI: 10.1016/0002-9343(82)90080-8.Peer-Reviewed Original ResearchConceptsHSV-2 infectionHerpes simplex virus type 1Simplex virus type 1Genital infectionVirus type 1Lumbosacral gangliaHSV-2Clinical diseaseLatent infectionHSV-1Guinea pigsHSV-1-infected animalsHSV-2-infected animalsType 1Herpes simplex virus type 2Simplex virus type 2Acyclovir-treated groupEffect of acyclovirHSV-1 strainsVirus type 2Systemic treatmentAcute infectionMild diseaseSpinal cordChronic changesThe need for a rapid and accurate viral diagnosis
Landry ML, Mayo DR, Hsiung GD. The need for a rapid and accurate viral diagnosis. Pharmacology & Therapeutics 1982, 18: 107-132. PMID: 6296887, DOI: 10.1016/0163-7258(82)90028-6.Peer-Reviewed Original Research