2021
Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics
Cheemarla NR, Watkins TA, Mihaylova VT, Wang B, Zhao D, Wang G, Landry ML, Foxman EF. Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics. Journal Of Experimental Medicine 2021, 218: e20210583. PMID: 34128960, PMCID: PMC8210587, DOI: 10.1084/jem.20210583.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngiotensin-Converting Enzyme 2Case-Control StudiesChemokine CXCL10COVID-19Disease SusceptibilityFemaleGene Expression ProfilingHost-Pathogen InteractionsHumansImmunity, InnateInterferonsMaleMiddle AgedNasopharynxPicornaviridae InfectionsSARS-CoV-2Viral LoadVirus ReplicationConceptsSARS-CoV-2 infectionSARS-CoV-2 exposureSARS-CoV-2Interferon-stimulated genesUpper respiratory tractRespiratory tractEarly SARS-CoV-2 infectionDynamic innate immune responseViral replicationSARS-CoV-2 replicationPatient nasopharyngeal samplesInnate immune responseLow infectious doseViral loadNasopharyngeal samplesImmune responseInfectious doseISG responseAntiviral responseInfection progressionViral transmissionLevel correlatesInfectionISG inductionInitial replication
2020
Clinical implications of SARS-CoV-2 cycle threshold values in solid organ transplant recipients
Gaston DC, Malinis M, Osborn R, Peaper DR, Landry M, Juthani-Mehta M, Azar MM. Clinical implications of SARS-CoV-2 cycle threshold values in solid organ transplant recipients. American Journal Of Transplantation 2020, 21: 1304-1311. PMID: 33043603, PMCID: PMC7675520, DOI: 10.1111/ajt.16357.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsOrgan transplant recipientsClinical implicationsCycle threshold valuesSOT patientsTransplant recipientsSymptom onsetYale New Haven Health SystemUpper respiratory tract samplesSARS-CoV-2 viral RNASARS-CoV-2 viral dynamicsAdult SOT recipientsRetrospective chart reviewRespiratory tract samplesSARS-CoV-2 cycle threshold valuesInfection prevention measuresCOVID-19 severityViral RNAHigher clinical acuityPrimary diagnostic testRT-PCR assaysSOT recipientsChart reviewViral loadAdmission severityAttenuated Novel SARS Coronavirus 2 Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient on Ruxolitinib
Foss FM, Rubinowitz A, Landry ML, Isufi I, Gowda L, Seropian S, Perreault S, Shenoi SV. Attenuated Novel SARS Coronavirus 2 Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient on Ruxolitinib. Clinical Lymphoma Myeloma & Leukemia 2020, 20: 720-723. PMID: 32727701, PMCID: PMC7316063, DOI: 10.1016/j.clml.2020.06.014.Peer-Reviewed Original ResearchMeSH KeywordsBetacoronavirusCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansImmunocompromised HostLymphoma, T-CellMaleMiddle AgedNitrilesPandemicsPneumonia, ViralPyrazolesPyrimidinesSARS-CoV-2Severity of Illness IndexTransplantation, HomologousTreatment OutcomeConceptsAllogeneic hematopoietic stem cell transplant patientsHematopoietic stem cell transplant patientsSevere acute respiratory syndrome coronavirus 2SARS coronavirus 2 (SARS-CoV-2) infectionSARS-CoV-2 pneumoniaAcute respiratory syndrome coronavirus 2Stem cell transplant patientsSARS-CoV-2 infectionRespiratory syndrome coronavirus 2Coronavirus 2 infectionCell transplant patientsCoV-2 infectionStem cell transplantationSyndrome coronavirus 2High death rateImmunocompromised stateJAK/STAT inhibitor ruxolitinibTransplant patientsCell transplantationCoronavirus 2Novel therapiesInhibitor ruxolitinibPatientsDeath rateRuxolitinib
2017
Fatal case of cutaneous‐sparing orolaryngeal zoster in a renal transplant recipient
Helou E, Grant M, Landry M, Wu X, Morrow JS, Malinis MF. Fatal case of cutaneous‐sparing orolaryngeal zoster in a renal transplant recipient. Transplant Infectious Disease 2017, 19 PMID: 28401625, DOI: 10.1111/tid.12704.Peer-Reviewed Case Reports and Technical NotesConceptsTransplant recipientsHerpes zosterSolid organ transplant recipientsCTLA-4 inhibitorsKidney transplant recipientsRenal transplant recipientsOrgan transplant recipientsAcute rejectionSOT recipientsMucosal lesionsMeningo-encephalitisPoor outcomeFatal casesHerpesvirus infectionSignificant causeRecipientsZosterPneumonitisMorbidityPatientsLesionsInfectionMortalityCases
2016
Characterizing Patients with Very-Low-Level HIV Viremia: A Community-Based Study
Helou E, Shenoi S, Kyriakides T, Landry ML, Kozal M, Barakat LA. Characterizing Patients with Very-Low-Level HIV Viremia: A Community-Based Study. Journal Of The International Association Of Providers Of AIDS Care (JIAPAC) 2016, 16: 261-266. PMID: 27903948, PMCID: PMC5423832, DOI: 10.1177/2325957416680028.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsCD4 Lymphocyte CountFemaleHIV InfectionsHIV-1HumansMaleMiddle AgedViral LoadViremiaConceptsVirologic failureViral load levelsPill burdenAlcohol useHuman immunodeficiency virus (HIV) careLow-level HIV viremiaUndetectable viral load levelsAntiretroviral regimen changesAntiretroviral therapy changesExperienced virologic failureLow-level viremiaIntravenous drug useSubset of patientsFrequent clinic visitsPoor clinical outcomePossible risk factorsHepatitis C virusHIV viremiaMore comorbiditiesNonfailure groupVirologic suppressionVirological failureCD4 countConsecutive chartsClinic visitsCytomegalovirus appendicitis in an immunocompetent host
Canterino JE, McCormack M, Gurung A, Passarelli J, Landry ML, Golden M. Cytomegalovirus appendicitis in an immunocompetent host. Journal Of Clinical Virology 2016, 78: 9-11. PMID: 26942831, DOI: 10.1016/j.jcv.2016.02.011.Peer-Reviewed Case Reports and Technical NotesConceptsImmune-compromising conditionsEnd-organ diseaseCommon viral pathogensCMV appendicitisCytomegalovirus appendicitisMononucleosis syndromeImmunocompetent hostsImmunocompetent individualsAsymptomatic infectionCommon manifestationHealthy individualsViral pathogensAppendicitisCytomegalovirusPatientsSyndromeInfectionDiseaseIndividuals
2014
Comparison of Simplexa Flu A/B & RSV PCR with Cytospin-Immunofluorescence and Laboratory-Developed TaqMan PCR in Predominantly Adult Hospitalized Patients
Landry ML, Ferguson D. Comparison of Simplexa Flu A/B & RSV PCR with Cytospin-Immunofluorescence and Laboratory-Developed TaqMan PCR in Predominantly Adult Hospitalized Patients. Journal Of Clinical Microbiology 2014, 52: 3057-3059. PMID: 24850350, PMCID: PMC4136128, DOI: 10.1128/jcm.00738-14.Peer-Reviewed Original Research
2013
Comparison of Simplexa HSV 1 & 2 PCR with Culture, Immunofluorescence, and Laboratory-Developed TaqMan PCR for Detection of Herpes Simplex Virus in Swab Specimens
Gitman MR, Ferguson D, Landry ML. Comparison of Simplexa HSV 1 & 2 PCR with Culture, Immunofluorescence, and Laboratory-Developed TaqMan PCR for Detection of Herpes Simplex Virus in Swab Specimens. Journal Of Clinical Microbiology 2013, 51: 3765-3769. PMID: 24006008, PMCID: PMC3889765, DOI: 10.1128/jcm.01413-13.Peer-Reviewed Original ResearchAdolescentAdultAgedAged, 80 and overChildChild, PreschoolClinical Laboratory TechniquesCosts and Cost AnalysisFemaleFluorescent Antibody TechniqueHerpes SimplexHumansInfantInfant, NewbornMaleMiddle AgedPolymerase Chain ReactionSensitivity and SpecificitySimplexvirusTime FactorsVirus CultivationYoung AdultHepatitis E virus infection in a liver transplant recipient: delayed diagnosis due to variable performance of serologic assays
Yoo N, Bernstein J, Caldwell C, Dong C, Drobeniuc J, Kamili S, Landry ML. Hepatitis E virus infection in a liver transplant recipient: delayed diagnosis due to variable performance of serologic assays. Transplant Infectious Disease 2013, 15: e166-e168. PMID: 23701647, DOI: 10.1111/tid.12096.Peer-Reviewed Original Research
2010
Serum 25-Hydroxyvitamin D and the Incidence of Acute Viral Respiratory Tract Infections in Healthy Adults
Sabetta JR, DePetrillo P, Cipriani RJ, Smardin J, Burns LA, Landry ML. Serum 25-Hydroxyvitamin D and the Incidence of Acute Viral Respiratory Tract Infections in Healthy Adults. PLOS ONE 2010, 5: e11088. PMID: 20559424, PMCID: PMC2885414, DOI: 10.1371/journal.pone.0011088.Peer-Reviewed Original ResearchConceptsAcute viral respiratory tract infectionsViral respiratory tract infectionsRespiratory tract infectionsAcute respiratory tract infectionsTract infectionsD concentrationsVitamin DSerum concentrationsViral infectionHealthy adultsVitamin D supplementationD serum concentrationsBurden of illnessFuture interventional studiesIncidence of infectionSpecific viral infectionsLean body massPrevalence of influenzaPercentage of daysDark-skinned individualsD supplementationPregnant womenInterventional studyGeneral populationInfection
2009
Herpes Simplex Type-2 Meningitis: Presentation and Lack of Standardized Therapy
Landry ML, Greenwold J, Vikram HR. Herpes Simplex Type-2 Meningitis: Presentation and Lack of Standardized Therapy. The American Journal Of Medicine 2009, 122: 688-691. PMID: 19559173, DOI: 10.1016/j.amjmed.2009.02.017.Peer-Reviewed Original ResearchConceptsHSV-2 meningitisGenital herpesHerpes simplex type 2Evidence of meningoencephalitisOral antiviral therapyRecurrent lymphocytic meningitisRetrospective observational studyTime of presentationSimplex type 2Optimal patient managementCerebrospinal fluid samplesSteroid injectionCesarean sectionLymphocytic meningitisOral therapyStandardized therapyAntiviral treatmentGenital symptomsIntravenous therapyRecurrent meningitisAntiviral therapySpinal stenosisGenital lesionsHSV-2Medical records
2008
Real-time PCR compared to Binax NOW and cytospin-immunofluorescence for detection of influenza in hospitalized patients
Landry ML, Cohen S, Ferguson D. Real-time PCR compared to Binax NOW and cytospin-immunofluorescence for detection of influenza in hospitalized patients. Journal Of Clinical Virology 2008, 43: 148-151. PMID: 18639488, PMCID: PMC7173065, DOI: 10.1016/j.jcv.2008.06.006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntibodies, MonoclonalChildChild, PreschoolFluorescent Antibody Technique, DirectHospitalizationHumansImmunoassayInfantInfluenza A virusInfluenza B virusInfluenza, HumanMiddle AgedNasopharynxReagent Kits, DiagnosticReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionSensitivity and SpecificityTaq PolymeraseTime FactorsVirus CultivationYoung AdultConceptsHospitalized patientsTaqMan RT-PCRRT-PCRInfluenza ARapid flu testsDiagnosis of influenzaInfluenza-positive samplesDetection of influenzaReal-time RT-PCRInfluenza BInfluenza diagnosisPatient managementReal-time PCRMore accurate testsPatientsBinaxTrue positive samplesRapid testClinical samplesPositive samplesFurther studiesHospitalAccurate testInfluenzaDiagnosis
2007
Genotype Prevalence and Risk Factors for Severe Clinical Adenovirus Infection, United States 2004–2006
Gray GC, McCarthy T, Lebeck MG, Schnurr DP, Russell KL, Kajon AE, Landry ML, Leland DS, Storch GA, Ginocchio CC, Robinson CC, Demmler GJ, Saubolle MA, Kehl SC, Selvarangan R, Miller MB, Chappell JD, Zerr DM, Kiska DL, Halstead DC, Capuano AW, Setterquist SF, Chorazy ML, Dawson JD, Erdman DD. Genotype Prevalence and Risk Factors for Severe Clinical Adenovirus Infection, United States 2004–2006. Clinical Infectious Diseases 2007, 45: 1120-1131. PMID: 17918073, PMCID: PMC2064001, DOI: 10.1086/522188.Peer-Reviewed Original ResearchConceptsAdenovirus infectionIntensive care unit staySolid organ transplantationChronic disease conditionsAdenovirus isolatesUnited States 2004Adenovirus-positive specimensRisk factor modelingTyping methodsUnit stayRisk factorsAntigenic presentationChronic diseasesGenotype prevalenceClinical dataOrgan transplantationSevere diseaseRecent transplantationBone marrowBlinded comparisonDisease severityMilitary traineesSequence typing methodInfectionCancer diagnosisMyelodysplastic syndrome with pure red cell aplasia shows characteristic clinicopathological features and clonal T‐cell expansion
Wang A, Yue G, Hutchinson L, Landry ML, Hasserjian RP, Hao S, Galili N, Raza A, Woda BA. Myelodysplastic syndrome with pure red cell aplasia shows characteristic clinicopathological features and clonal T‐cell expansion. British Journal Of Haematology 2007, 138: 271-275. PMID: 17542981, DOI: 10.1111/j.1365-2141.2007.06648.x.Peer-Reviewed Original ResearchSerum IgA Antibodies to Epstein-Barr Virus (EBV) Early Lytic Antigens Are Present in Primary EBV Infection
Bhaduri-McIntosh S, Landry ML, Nikiforow S, Rotenberg M, El-Guindy A, Miller G. Serum IgA Antibodies to Epstein-Barr Virus (EBV) Early Lytic Antigens Are Present in Primary EBV Infection. The Journal Of Infectious Diseases 2007, 195: 483-492. PMID: 17230407, DOI: 10.1086/510916.Peer-Reviewed Original ResearchConceptsPrimary EBV infectionSerum IgA antibodiesIgA antibodiesEBV infectionLytic antigensPrimary infectionPrimary Epstein-Barr virus infectionHealthy EBV-seropositive individualsEpstein-Barr virus infectionEB nuclear antigenEBV-seropositive individualsViral capsid antigenAbsence of antibodiesFlow cytometry-based assayLytic EBV replicationCytometry-based assayBurkitt's lymphoma cellsCapsid antigenMucosal sitesEBV replicationIgM antibodiesVirus infectionInfectionLymphoma cellsSerum samples
2006
Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease
Martinello RA, Esper F, Weibel C, Ferguson D, Landry ML, Kahn JS. Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease. Journal Of Infection 2006, 53: 248-254. PMID: 16412516, PMCID: PMC7112509, DOI: 10.1016/j.jinf.2005.11.010.Peer-Reviewed Original ResearchConceptsExacerbation of COPDChronic obstructive pulmonary diseaseObstructive pulmonary diseaseRespiratory syncytial virusHuman metapneumovirusPulmonary diseaseSyncytial virusObservational cohort studyRespiratory tract infectionsParainfluenza type 3Urban teaching hospitalCOPD patientsCohort studyTract infectionsParainfluenza 1HMPV genotypesRespiratory virusesNasopharyngeal specimensViral cultureEnrollment criteriaInfluenza ATeaching hospitalDirect immunofluorescenceExacerbationPatients
2005
Real-Time Nucleic Acid Sequence-Based Amplification Using Molecular Beacons for Detection of Enterovirus RNA in Clinical Specimens
Landry ML, Garner R, Ferguson D. Real-Time Nucleic Acid Sequence-Based Amplification Using Molecular Beacons for Detection of Enterovirus RNA in Clinical Specimens. Journal Of Clinical Microbiology 2005, 43: 3136-3139. PMID: 16000425, PMCID: PMC1169110, DOI: 10.1128/jcm.43.7.3136-3139.2005.Peer-Reviewed Original ResearchConceptsNucleic acid sequence-based amplificationTime Nucleic Acid Sequence-Based AmplificationEV-positive samplesReal-time nucleic acid sequence-based amplificationDetection of enterovirusesEnterovirus RNAStool samplesCerebrospinal fluidNASBA assayClinical specimensEnterovirusesMolecular beacon technologyAssays
1996
Use of a quantitative cytomegalovirus (CMV) antigenemia test in evaluating HIV+ patients with and without CMV disease.
Wetherill PE, Landry ML, Alcabes P, Friedland G. Use of a quantitative cytomegalovirus (CMV) antigenemia test in evaluating HIV+ patients with and without CMV disease. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1996, 12: 33-7. PMID: 8624758, DOI: 10.1097/00042560-199605010-00005.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAntibodies, MonoclonalAntigens, ViralCross-Sectional StudiesCytomegalovirusCytomegalovirus InfectionsCytomegalovirus RetinitisFemaleFluorescent Antibody TechniqueHIV SeropositivityHIV-1HumansLeukocytesMaleMiddle AgedPredictive Value of TestsRetrospective StudiesViral Matrix ProteinsViremiaConceptsCMV antigenemia testCMV diseaseAntigenemia testCMV antigenemiaHIV diseaseCytomegalovirus antigenemia testPositive CMV antigenemiaLife-threatening infectionsDiagnostic techniquesAntigenemia levelsAntigenemia resultsCMV retinitisCytomegalovirus infectionCMV cultureClinical evidenceOphthalmologic examPatientsDiseaseRapid diagnosisAntigenemiaInfectionDiagnosisQuantitative diagnostic techniqueRetinitisHIV
1993
Comparison of quantitative cytomegalovirus antigenemia assay with culture methods and correlation with clinical disease
Landry ML, Ferguson D. Comparison of quantitative cytomegalovirus antigenemia assay with culture methods and correlation with clinical disease. Journal Of Clinical Microbiology 1993, 31: 2851-2856. PMID: 8263166, PMCID: PMC266143, DOI: 10.1128/jcm.31.11.2851-2856.1993.Peer-Reviewed Original ResearchConceptsCMV antigenemiaCentrifugation cultureClinical diseaseCMV antigensBlood samplesConventional cultureDetection of cytomegalovirusQuantitative cytomegalovirus antigenemiaHuman immunodeficiency virus-infected patientsBone marrow transplant recipientsCMV antigenemia testHigh-level antigenemiaVirus-infected patientsMarrow transplant recipientsDetection of antigenemiaCulture methodUse of immunofluorescenceAntigenemia testTransplant recipientsCMV infectionCytomegalovirus antigenemiaAntigenemiaIndividual patientsImmunoperoxidase stainingRapid diagnosisComparison of latex agglutination test with enzyme-linked immunosorbent assay for detection of antibody to varicella-zoster virus
Landry ML, Ferguson D. Comparison of latex agglutination test with enzyme-linked immunosorbent assay for detection of antibody to varicella-zoster virus. Journal Of Clinical Microbiology 1993, 31: 3031-3033. PMID: 8263191, PMCID: PMC266199, DOI: 10.1128/jcm.31.11.3031-3033.1993.Peer-Reviewed Original Research