2021
Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics
Cheemarla NR, Watkins TA, Mihaylova VT, Wang B, Zhao D, Wang G, Landry ML, Foxman EF. Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics. Journal Of Experimental Medicine 2021, 218: e20210583. PMID: 34128960, PMCID: PMC8210587, DOI: 10.1084/jem.20210583.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngiotensin-Converting Enzyme 2Case-Control StudiesChemokine CXCL10COVID-19Disease SusceptibilityFemaleGene Expression ProfilingHost-Pathogen InteractionsHumansImmunity, InnateInterferonsMaleMiddle AgedNasopharynxPicornaviridae InfectionsSARS-CoV-2Viral LoadVirus ReplicationConceptsSARS-CoV-2 infectionSARS-CoV-2 exposureSARS-CoV-2Interferon-stimulated genesUpper respiratory tractRespiratory tractEarly SARS-CoV-2 infectionDynamic innate immune responseViral replicationSARS-CoV-2 replicationPatient nasopharyngeal samplesInnate immune responseLow infectious doseViral loadNasopharyngeal samplesImmune responseInfectious doseISG responseAntiviral responseInfection progressionViral transmissionLevel correlatesInfectionISG inductionInitial replication
2009
Low-Abundance HIV Drug-Resistant Viral Variants in Treatment-Experienced Persons Correlate with Historical Antiretroviral Use
Le T, Chiarella J, Simen BB, Hanczaruk B, Egholm M, Landry ML, Dieckhaus K, Rosen MI, Kozal MJ. Low-Abundance HIV Drug-Resistant Viral Variants in Treatment-Experienced Persons Correlate with Historical Antiretroviral Use. PLOS ONE 2009, 4: e6079. PMID: 19562031, PMCID: PMC2698118, DOI: 10.1371/journal.pone.0006079.Peer-Reviewed Original ResearchConceptsAntiretroviral treatment historyDrug-resistant mutationsVirologic failureAntiretroviral useDrug-resistant variantsTreatment historyOverall burdenGenotypic resistanceHIV drug-resistant mutationsHIV drug-resistant variantsStanford HIV database algorithmDrug-resistant viral variantsSubsequent antiretroviral regimensTreatment-experienced patientsConventional genotypingPrior treatment historyUltra-deep pyrosequencingSanger sequencingAntiretroviral regimensMore antiretroviralsChart reviewAntiretroviral drugsUltra-deep sequencingClinical implicationsViral variants
1987
Replication of human adenoviruses in guinea pig embryo cells: an ultrastructural study
Fong C, Landry M, Hsiung GD. Replication of human adenoviruses in guinea pig embryo cells: an ultrastructural study. Archives Of Virology 1987, 93: 247-260. PMID: 3827599, DOI: 10.1007/bf01310978.Peer-Reviewed Original ResearchConceptsProgeny virusAdenovirus 2Cellular changesEmbryo cellsHuman adenovirus 2Adenovirus typesHuman cellsCell typesAdenovirus 3Human adenovirusesCellsProtein crystalsElectron microscopic examinationAdenovirus 31Human adenovirus typesAdenovirus 7Virus infectivity assaysInfectivity assaysBiological propertiesUltrastructural studyVirusGuinea pig embryo cellsInfectious virusReplicationCharacteristic fibers
1985
Comparison of Four Methods for Typing Low-Passage Herpes Simplex Virus Isolates
Mayo D, Hilliard J, Landry M, Egbertson S, Mirkovic R. Comparison of Four Methods for Typing Low-Passage Herpes Simplex Virus Isolates. Intervirology 1985, 23: 112-115. PMID: 2984142, DOI: 10.1159/000149593.Peer-Reviewed Original ResearchConceptsHerpes simplex virusGuinea pig embryo cellsHerpes simplex virus isolatesHSV type 1Direct fluorescent antibody techniqueFluorescent antibody techniqueSimplex virusType 2Clinical isolatesEmbryo cellsType 1Virology laboratoryContinuous cell linesBVDU sensitivityMonoclonal antibodiesChick embryo cellsAntibody techniqueVirus isolatesRestriction endonuclease analysisCell linesIsolatesEndonuclease analysisTyping systemCells