2018
Detection of Influenza A and B Viruses and Respiratory Syncytial Virus by Use of Clinical Laboratory Improvement Amendments of 1988 (CLIA)-Waived Point-of-Care Assays: a Paradigm Shift to Molecular Tests
Azar MM, Landry ML. Detection of Influenza A and B Viruses and Respiratory Syncytial Virus by Use of Clinical Laboratory Improvement Amendments of 1988 (CLIA)-Waived Point-of-Care Assays: a Paradigm Shift to Molecular Tests. Journal Of Clinical Microbiology 2018, 56: 10.1128/jcm.00367-18. PMID: 29695519, PMCID: PMC6018333, DOI: 10.1128/jcm.00367-18.BooksConceptsRapid influenza diagnostic testsRespiratory syncytial virusNucleic acid amplification testsSyncytial virusB virusInfluenza AClinical Laboratory Improvement AmendmentsAntiviral therapyPoint of careAvailable rapid influenza diagnostic testsSensitive nucleic acid amplification testsMolecular testsInfluenza diagnostic testsRespiratory virus infectionsInfection prevention strategiesRapid antigen detectionRapid laboratory testingViral diagnostic testingDetection of influenzaNew pandemic strainsAccurate laboratory diagnosisRapid antigenRespiratory virusesViral culturePatient management
2009
Rhinoviruses Are a Major Cause of Wheezing and Hospitalization in Children Less Than 2 Years of Age
Piotrowska Z, Vázquez M, Shapiro ED, Weibel C, Ferguson D, Landry ML, Kahn JS. Rhinoviruses Are a Major Cause of Wheezing and Hospitalization in Children Less Than 2 Years of Age. The Pediatric Infectious Disease Journal 2009, 28: 25-29. PMID: 19057454, PMCID: PMC4639321, DOI: 10.1097/inf.0b013e3181861da0.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusHRV-positive childrenHuman rhinovirusSyncytial virusAge groupsDiagnostic laboratoriesRespiratory tract diseaseMajor respiratory pathogenRate of infectionYears of ageSimilar age groupAsymptomatic childrenRespiratory specimenAsymptomatic groupRespiratory infectionsHRV infectionHospitalization ratesPolymerase chain reactionTract diseaseRespiratory pathogensHRV isolatesMajor causeStudy periodSymptomsInfection
2006
Human Bocavirus Infection in Young Children in the United States: Molecular Epidemiological Profile and Clinical Characteristics of a Newly Emerging Respiratory Virus
Kesebir D, Vazquez M, Weibel C, Shapiro ED, Ferguson D, Landry ML, Kahn JS. Human Bocavirus Infection in Young Children in the United States: Molecular Epidemiological Profile and Clinical Characteristics of a Newly Emerging Respiratory Virus. The Journal Of Infectious Diseases 2006, 194: 1276-1282. PMID: 17041854, PMCID: PMC7204143, DOI: 10.1086/508213.Peer-Reviewed Original ResearchConceptsRespiratory tract diseasePolymerase chain reactionAsymptomatic childrenClinical characteristicsEpidemiological profileRespiratory specimensTract diseaseLower respiratory tract diseaseHBoV-positive childrenHuman bocavirus infectionRespiratory syncytial virusMolecular epidemiological profileYears of ageYoung childrenDiagnostic laboratoriesBocavirus infectionRespiratory specimenAbnormal findingsRespiratory virusesRespiratory secretionsSyncytial virusHuman bocavirusParainfluenza virusB virusChest radiographyCoronavirus HKU1 Infection in the United States
Esper F, Weibel C, Ferguson D, Landry ML, Kahn JS. Coronavirus HKU1 Infection in the United States. Emerging Infectious Diseases 2006, 12: 775-779. PMID: 16704837, PMCID: PMC3374449, DOI: 10.3201/eid1205.051316.Peer-Reviewed Original ResearchConceptsHCoV-HKU1Respiratory specimensLower respiratory tract infectionsLower respiratory tract diseaseHCoV-HKU1 infectionRespiratory tract infectionsRespiratory syncytial virusRespiratory tract diseaseReverse transcription-polymerase chain reactionNew human coronavirusYears of ageTranscription-polymerase chain reactionTract infectionsSyncytial virusPositive childrenParainfluenza virusTract diseaseRespiratory tractHuman coronavirusesPositive specimensInfluenza virusInfectionChain reactionChildrenVirusHuman metapneumovirus and exacerbations of chronic obstructive pulmonary disease
Martinello RA, Esper F, Weibel C, Ferguson D, Landry ML, Kahn JS. Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease. Journal Of Infection 2006, 53: 248-254. PMID: 16412516, PMCID: PMC7112509, DOI: 10.1016/j.jinf.2005.11.010.Peer-Reviewed Original ResearchConceptsExacerbation of COPDChronic obstructive pulmonary diseaseObstructive pulmonary diseaseRespiratory syncytial virusHuman metapneumovirusPulmonary diseaseSyncytial virusObservational cohort studyRespiratory tract infectionsParainfluenza type 3Urban teaching hospitalCOPD patientsCohort studyTract infectionsParainfluenza 1HMPV genotypesRespiratory virusesNasopharyngeal specimensViral cultureEnrollment criteriaInfluenza ATeaching hospitalDirect immunofluorescenceExacerbationPatients
2004
A 1-Year Experience with Human Metapneumovirus in Children Aged <5 Years
Esper F, Martinello RA, Boucher D, Weibel C, Ferguson D, Landry ML, Kahn JS. A 1-Year Experience with Human Metapneumovirus in Children Aged <5 Years. The Journal Of Infectious Diseases 2004, 189: 1388-1396. PMID: 15073675, PMCID: PMC7109939, DOI: 10.1086/382482.Peer-Reviewed Original ResearchConceptsHuman metapneumovirusPresence of hMPVStudy periodHMPV-positive childrenRespiratory syncytial virusParainfluenza virus 1Respiratory tract diseaseReverse transcription-polymerase chain reactionDirect fluorescent antibody testFluorescent antibody testSyncytial virusRespiratory specimensPolymerase chain reactionChildren AgedCommon findingInfluenza ARespiratory pathogensChest wallAntibody testVirus 1Chain reactionNegative resultsMetapneumovirusSignificant proportionChildren
2003
Suboptimal Detection of Influenza Virus in Adults by the Directigen Flu A+B Enzyme Immunoassay and Correlation of Results with the Number of Antigen-Positive Cells Detected by Cytospin Immunofluorescence
Landry ML, Ferguson D. Suboptimal Detection of Influenza Virus in Adults by the Directigen Flu A+B Enzyme Immunoassay and Correlation of Results with the Number of Antigen-Positive Cells Detected by Cytospin Immunofluorescence. Journal Of Clinical Microbiology 2003, 41: 3407-3409. PMID: 12843105, PMCID: PMC165325, DOI: 10.1128/jcm.41.7.3407-3409.2003.Peer-Reviewed Original ResearchConceptsVirus infectionEnzyme immunoassayDirectigen FluParainfluenza virus infectionPositive EIA resultsRespiratory syncytial virusAntigen-positive cellsNasopharyngeal swabsSyncytial virusEmergency departmentInfluenza diagnosisDirect immunofluorescenceInfluenza virusVirology laboratoryEIA resultsNight shiftsInfectionInfluenzaImmunofluorescenceFluAdultsVirusCorrelation of resultsImmunoassayCells
2000
Respiratory Syncytial Virus Stimulation of Vascular Endothelial Cell Growth Factor/Vascular Permeability Factor
Lee C, Yoon H, Zhu Z, Link H, Wang Z, Gwaltney J, Landry M, Elias J. Respiratory Syncytial Virus Stimulation of Vascular Endothelial Cell Growth Factor/Vascular Permeability Factor. American Journal Of Respiratory Cell And Molecular Biology 2000, 23: 662-669. PMID: 11062145, DOI: 10.1165/ajrcmb.23.5.4188.Peer-Reviewed Original ResearchConceptsVascular endothelial cell growth factorVEGF/VPFRespiratory syncytial virus stimulationRespiratory syncytial virusAcid isoformNormal human bronchial epithelial cellsEndothelial cell growth factorHuman bronchial epithelial cellsUnstimulated A549 cellsVascular permeability factorBronchial epithelial cellsCell growth factorVEGF messenger RNARSV infectionSyncytial virusVirus stimulationNasal washingsVirus infectionSignificant cell cytotoxicityPotent stimulatorCell cytotoxicityGrowth factorElevated levelsPermeability factorA549 cells
1996
Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness.
Einarsson O, Geba G, Zhu Z, Landry M, Elias J. Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness. Journal Of Clinical Investigation 1996, 97: 915-924. PMID: 8613544, PMCID: PMC507136, DOI: 10.1172/jci118514.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusIL-11 productionParainfluenza virus type 3Airway hyperresponsivenessIL-11Viral upper respiratory tract infectionUpper respiratory tract infectionBALB/c miceSimplex virus type 2Viral-induced asthmaViral respiratory infectionsRespiratory tract infectionsNonspecific airway hyperresponsivenessVirus type 2Virus type 3Clinical bronchospasmAirway dysfunctionAirway physiologyTract infectionsRespiratory infectionsRespiratory virusesSyncytial virusC miceNasal aspiratesViral infection
1994
Epithelial interleukin-11. Regulation by cytokines, respiratory syncytial virus, and retinoic acid.
Elias J, Zheng T, Einarsson O, Landry M, Trow T, Rebert N, Panuska J. Epithelial interleukin-11. Regulation by cytokines, respiratory syncytial virus, and retinoic acid. Journal Of Biological Chemistry 1994, 269: 22261-22268. PMID: 8071352, DOI: 10.1016/s0021-9258(17)31785-4.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusIL-11 productionIL-11 protein productionIL-1IL-11Retinoic acidSyncytial virusSimplex virus type 2Growth factorIL-11 mRNADose-dependent fashionVirus type 2Hepatocyte growth factorStimulus-specific fashionIL-6IL-4IL-7Alveolar A549 cellsPleiotropic cytokineType 2Human alveolar A549 cellsInterleukin-11Epithelial cellsA549 cellsUnstimulated cells