2021
A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice
Mao T, Israelow B, Lucas C, Vogels CBF, Gomez-Calvo ML, Fedorova O, Breban MI, Menasche BL, Dong H, Linehan M, Alpert T, Anderson F, Earnest R, Fauver J, Kalinich C, Munyenyembe K, Ott I, Petrone M, Rothman J, Watkins A, Wilen C, Landry M, Grubaugh N, Pyle A, Iwasaki A. A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice. Journal Of Experimental Medicine 2021, 219: e20211818. PMID: 34757384, PMCID: PMC8590200, DOI: 10.1084/jem.20211818.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionChronic SARS-CoV-2 infectionVariants of concernLethal SARS-CoV-2 infectionPost-infection therapyLower respiratory tractPost-exposure treatmentType I interferonSARS-CoV-2Effective medical countermeasuresAdaptive immune systemBroad-spectrum antiviralsContext of infectionSingle doseRespiratory tractViral controlImmunodeficient miceSevere diseaseMouse modelI interferonViral infectionImmune systemInnate immunityDisease preventionConsiderable efficacy
2009
Emergent US adenovirus 3 strains associated with an epidemic and serious disease
Lebeck MG, McCarthy TA, Capuano AW, Schnurr DP, Landry ML, Setterquist SF, Heil GL, Kilic S, Gray GC. Emergent US adenovirus 3 strains associated with an epidemic and serious disease. Journal Of Clinical Virology 2009, 46: 331-336. PMID: 19854101, PMCID: PMC2806089, DOI: 10.1016/j.jcv.2009.09.023.Peer-Reviewed Original ResearchConceptsClinical diseaseSevere diseaseSevere clinical diseaseYears of ageRisk factor modelingRisk factorsChronic diseasesAdenovirus type 3Emergent strainsPrevalent serotypesHAdV3DiseaseMultivariate modelingType 3Serious diseaseRare strainsNovel variantsRestriction enzyme analysisAdenovirus 3Genomic characterizationEnzyme analysisStatistical analysisUS laboratoriesPersonsVariantsAdenovirus type 3 outbreak in connecticut associated with a novel variant
Landry ML, Lebeck MG, Capuano AW, McCarthy T, Gray GC. Adenovirus type 3 outbreak in connecticut associated with a novel variant. Journal Of Medical Virology 2009, 81: 1380-1384. PMID: 19551823, PMCID: PMC2897138, DOI: 10.1002/jmv.21539.Peer-Reviewed Original Research
2007
Genotype Prevalence and Risk Factors for Severe Clinical Adenovirus Infection, United States 2004–2006
Gray GC, McCarthy T, Lebeck MG, Schnurr DP, Russell KL, Kajon AE, Landry ML, Leland DS, Storch GA, Ginocchio CC, Robinson CC, Demmler GJ, Saubolle MA, Kehl SC, Selvarangan R, Miller MB, Chappell JD, Zerr DM, Kiska DL, Halstead DC, Capuano AW, Setterquist SF, Chorazy ML, Dawson JD, Erdman DD. Genotype Prevalence and Risk Factors for Severe Clinical Adenovirus Infection, United States 2004–2006. Clinical Infectious Diseases 2007, 45: 1120-1131. PMID: 17918073, PMCID: PMC2064001, DOI: 10.1086/522188.Peer-Reviewed Original ResearchConceptsAdenovirus infectionIntensive care unit staySolid organ transplantationChronic disease conditionsAdenovirus isolatesUnited States 2004Adenovirus-positive specimensRisk factor modelingTyping methodsUnit stayRisk factorsAntigenic presentationChronic diseasesGenotype prevalenceClinical dataOrgan transplantationSevere diseaseRecent transplantationBone marrowBlinded comparisonDisease severityMilitary traineesSequence typing methodInfectionCancer diagnosis
1984
Laboratory diagnosis of herpes simplex virus type 1 and type 2 infections
Hsiung GD, Landry ML, Mayo DR, Fong C. Laboratory diagnosis of herpes simplex virus type 1 and type 2 infections. Clinics In Dermatology 1984, 2: 67-82. PMID: 6100717, DOI: 10.1016/0738-081x(84)90067-1.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntibodies, ViralCells, CulturedCytopathogenic Effect, ViralDNA Restriction EnzymesFluorescent Antibody TechniqueHerpes GenitalisHerpes LabialisHerpes SimplexHumansImmunoenzyme TechniquesInclusion Bodies, ViralMicroscopy, ElectronNucleic Acid HybridizationSimplexvirusSpecimen HandlingVirionConceptsHerpes simplex virusHSV infectionHSV-2Virus isolationRecurrence of diseaseCommon viral infectionsEffective antiviral therapyType 2 infectionHerpes simplex virus type 1Simplex virus type 1HSV-1 infectionVirus type 1Fever blistersHSV isolationHerpetic lesionsAntiviral therapyClinical findingsGenital lesionsCommon manifestationDrug reactionsAllergic reactionsSevere diseaseGenital areaSimplex virusInfection results