2022
MIF is a common genetic determinant of COVID-19 symptomatic infection and severity
Shin JJ, Fan W, Par-Young J, Piecychna M, Leng L, Israni-Winger K, Qing H, Gu J, Zhao H, Schulz WL, Unlu S, Kuster J, Young G, Liu J, Ko AI, Garcia A, Sauler M, Wisnewski AV, Young L, Orduña A, Wang A, Klementina O, Garcia AB, Hegyi P, Armstrong ME, Mitchell P, Ordiz DB, Garami A, Kang I, Bucala R. MIF is a common genetic determinant of COVID-19 symptomatic infection and severity. QJM 2022, 116: 205-212. PMID: 36222594, PMCID: PMC9620729, DOI: 10.1093/qjmed/hcac234.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorLow-expression MIF alleleCOVID-19 infectionMIF allelesCATT7 alleleHealthy controlsCOVID-19Serum macrophage migration inhibitory factorSymptomatic SARS-CoV-2 infectionHigher serum MIF levelsHigh-expression MIF allelesRetrospective case-control studySARS-CoV-2 infectionFunctional polymorphismsAvailable clinical characteristicsMultinational retrospective studySerum MIF levelsUninfected healthy controlsSymptomatic COVID-19Tertiary medical centerHealthy control subjectsCase-control studyMigration inhibitory factorCoronavirus disease 2019Common functional polymorphisms
2016
MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis
Yoo SA, Leng L, Kim BJ, Du X, Tilstam PV, Kim KH, Kong JS, Yoon HJ, Liu A, Wang T, Song Y, Sauler M, Bernhagen J, Ritchlin CT, Lee P, Cho CS, Kim WU, Bucala R. MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e7917-e7926. PMID: 27872288, PMCID: PMC5150393, DOI: 10.1073/pnas.1612717113.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorHigh-expression MIF allelesJoint destructionRheumatoid arthritisMIF allelesProgressive joint destructionInvasive phenotypeFibroblast-like synoviocytesMigration inhibitory factorJoint erosionsMIF receptorAutoimmune responseMIF pathwaySynovial fibroblastsCell surface CD74Autocrine pathwayCD44 expressionInhibitory factorPharmacologic inhibitionTumor invasionArthritisInvasive propertiesCD44 receptorCD44Receptor complex