Spatial Transcriptomics Resolve an Emphysema-specific Lymphoid Follicle B Cell Signature in COPD.
Rojas-Quintero J, Ochsner S, New F, Divakar P, Yang C, Wu T, Robinson J, Shimoga Chandrashekar D, Banovich N, Rosas I, Sauler M, Kheradmand F, Gaggar A, Margaroli C, San Jose Estepar R, McKenna N, Polverino F. Spatial Transcriptomics Resolve an Emphysema-specific Lymphoid Follicle B Cell Signature in COPD. American Journal Of Respiratory And Critical Care Medicine 2023 PMID: 38064378, DOI: 10.1164/rccm.202303-0507oc.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseB cell activationLymphoid folliclesCOPD patientsGOLD 1Cell activationChronic B-cell activationObstructive pulmonary diseaseB cell signaturesAnti-inflammatory profileChest CT scanDegree of emphysemaB cell marker genesB cell maturationSevere emphysemaPulmonary diseaseEmphysema measurementsLung sectionsAntigen presentationGOLD 3Centrilobular emphysemaCT scanImmune componentsEmphysema pathogenesisEmphysema