1987
Dissociation of electrophysiologic and pharmacologic stability during an abbreviated oral loading regimen of amiodarone
Rosenfeld L, Kennedy E, Perlmutter R, Bookbinder M, McPherson C, Batsford W. Dissociation of electrophysiologic and pharmacologic stability during an abbreviated oral loading regimen of amiodarone. American Heart Journal 1987, 114: 1367-1374. PMID: 3687689, DOI: 10.1016/0002-8703(87)90538-2.Peer-Reviewed Original ResearchConceptsVentricular tachycardiaMicrograms/Sinus node recovery timeCycle lengthLoading regimenEarly outpatient managementOral loading regimenSinus cycle lengthSinoatrial conduction timeWenckebach cycle lengthVentricular refractory periodsDesethylamiodarone levelsElectrophysiologic testingHV intervalOutpatient managementElectrophysiologic studySerum levelsInpatient therapyElectrophysiologic changesTreatment periodConduction timeHigh-pressure liquid chromatographyRefractory periodDosing phaseRegimen
1986
Mechanisms and relevance of arrhythmias induced by high-current programmed ventricular stimulation
Kennedy E, Rosenfeld L, McPherson C, Stark S, Batsford W. Mechanisms and relevance of arrhythmias induced by high-current programmed ventricular stimulation. The American Journal Of Cardiology 1986, 57: 598-603. PMID: 3953446, DOI: 10.1016/0002-9149(86)90842-8.Peer-Reviewed Original ResearchConceptsSustained ventricular tachycardiaVentricular fibrillationTriple extrastimuliVentricular stimulationVentricular tachycardiaDiastolic thresholdConduction timeCoupling intervalExtrastimulus coupling intervalLocal conduction timeIntraventricular conduction timeVentricular refractory periodsUncertain clinical significanceVentricular refractorinessSustained arrhythmiaClinical significanceRefractory periodStimulation modalitiesExtrastimuliStimulationTachycardiaPatientsArrhythmogenicityArrhythmiasGreater increment
1985
Evaluation by serial electrophysiologic studies of an abbreviated oral loading regimen of amiodarone
Kennedy E, Rosenfeld L, McPherson C, Batsford W. Evaluation by serial electrophysiologic studies of an abbreviated oral loading regimen of amiodarone. The American Journal Of Cardiology 1985, 56: 867-871. PMID: 3904386, DOI: 10.1016/0002-9149(85)90772-6.Peer-Reviewed Original ResearchConceptsVentricular tachycardia cycle lengthOral loading regimenTachycardia cycle lengthVentricular refractory periodsVentricular tachycardia inducibilityTachycardia inducibilityAV nodal Wenckebach cycle lengthCycle lengthRefractory periodLoading regimenSerial electrophysiologic testingMonths of therapyWeeks of therapyLow maintenance doseSerial electrophysiologic studiesWenckebach cycle lengthMinority of casesMaintenance therapyOral amiodaroneElectrophysiologic testingMaintenance doseMaintenance regimensHV intervalElectrophysiologic studyAH interval