2024
Impact of a multicomponent strategy including decentralized molecular testing for tuberculosis on mortality: planned analysis of a cluster-randomized trial in Uganda
Katamba A, Mochizuki T, Nalugwa T, Nantale M, Oyuku D, Nabwire S, Babirye D, Musinguzi J, Nakawesa A, Nekesa I, Turyahabwe S, Joloba M, Dowdy D, Moore D, Davis J, Shete P, Adams K, Reza T, Fielding K, Cattamanchi A. Impact of a multicomponent strategy including decentralized molecular testing for tuberculosis on mortality: planned analysis of a cluster-randomized trial in Uganda. EClinicalMedicine 2024, 78: 102953. PMCID: PMC11629260, DOI: 10.1016/j.eclinm.2024.102953.Peer-Reviewed Original ResearchCommunity health centersCluster randomized trialHealth centersPragmatic cluster randomized trialMulticomponent strategiesSix-month mortality riskSecondary outcomesPan African Clinical Trials RegistryCluster-level analysisPatient-level covariatesAll-cause mortalityClinical Trials RegistryIntervention armSub-group analysisTB careMortality risk analysisRoutine careVital statusTrial armsMagnitude of effectPresumptive TBRate ratiosProximal outcomesTrial participantsUS National InstitutesBurden of tuberculosis in underserved populations in South Africa: A systematic review and meta-analysis
Holtgrewe L, Johnson A, Nyhan K, Boffa J, Shenoi S, Karat A, Davis J, Charalambous S. Burden of tuberculosis in underserved populations in South Africa: A systematic review and meta-analysis. PLOS Global Public Health 2024, 4: e0003753. PMID: 39361564, PMCID: PMC11449336, DOI: 10.1371/journal.pgph.0003753.Peer-Reviewed Original ResearchLatent TB infection prevalenceLatent TB infectionUnderserved populationsTB prevalenceMeta-analysisSystematic reviewNational averagePrevalence of TB diseaseCalculate prevalence ratiosTB diseaseCase-finding strategiesPopulation of personsAssessed study qualityHigh TB prevalenceHigh-burden countriesBurden of tuberculosisTB interventionsPrevalence ratiosStudy qualityReduce tuberculosisHIV statusActive TB diseaseGeneral populationModerate heterogeneityTB incidenceA Scoping Review of Factors Associated with HIV Acquisition in the Context of Humanitarian Crises
Harsono D, Atre S, Peterson H, Nyhan K, Garmroudi D, Davis J, Ho W, Khoshnood K. A Scoping Review of Factors Associated with HIV Acquisition in the Context of Humanitarian Crises. AIDS And Behavior 2024, 1-50. PMID: 39292318, DOI: 10.1007/s10461-024-04504-x.Peer-Reviewed Original ResearchFactors associated with HIV acquisitionHIV acquisitionContext of humanitarian crisesHumanitarian crisisHIV prevalenceUptake of HIV prevention strategiesJoanna Briggs Institute methodologyCulturally appropriate HIV prevention interventionsSexually transmitted infection diagnosisMeta-Analysis extensionHIV prevention interventionsSocial ecological modelHIV prevention strategiesNon-modifiable factorsRisk factorsVulnerability to HIV infectionPreferred Reporting ItemsExperience of rapeInternally displaced personsNon-government organizationsMultilevel barriersSingle-country studiesInstitute methodologyCommunity healthHealth servicesAn adapted scale to measure perceived TB and HIV stigma during household contact investigation.
Armstrong-Hough M, Shelby T, Ggita J, Nangendo J, Gupta A, Davis J, Katamba A. An adapted scale to measure perceived TB and HIV stigma during household contact investigation. The International Journal Of Tuberculosis And Lung Disease 2024, 28: 433-438. PMID: 39187997, DOI: 10.5588/ijtld.23.0395.Peer-Reviewed Original ResearchConceptsHousehold contact investigationStigma ScaleTB-HIVNewly diagnosed TB patientsContact investigationCognitive interview dataHIV stigmaHealth behaviorsFactor analysisCognitive interviewsElimination of itemsInter-item covariationStandardised measuresPsychometric propertiesRandom sampleTB patientsInterview dataHIVIdentifying opportunitiesStigmaHousehold contactsItemsScoresHouseholdsCovariatesLung function and health-related quality of life among adult patients following pulmonary TB treatment.
Zawedde J, Abelman R, Musisi E, Nyabigambo A, Sanyu I, Kaswabuli S, Byanyima P, Lewis E, Sessolo A, Lalitha R, Kiwanuka N, Crothers K, Worodria W, Davis J, Huang L. Lung function and health-related quality of life among adult patients following pulmonary TB treatment. The International Journal Of Tuberculosis And Lung Disease 2024, 28: 419-426. PMID: 39187999, DOI: 10.5588/ijtld.24.0029.Peer-Reviewed Original ResearchConceptsSt. George's Respiratory QuestionnaireQuality of lifeAbnormal lung functionSpirometric restrictionHealth-related quality of lifeLung functionPost-TB lung diseaseHealth-related qualityFemale sexRisk factorsFunctional abnormalitiesGeorge's Respiratory QuestionnairePTB treatmentPulmonary TB treatmentAssociated with increased morbidityChronic lung complicationsPrevalence ratiosResource-limited settingsChest X-rayLung function abnormalitiesRespiratory QuestionnaireSGRQ scoreAssociated with lung function abnormalitiesSmoking statusBilateral consolidationUsing mHealth Technologies for Case Finding in Tuberculosis and Other Infectious Diseases in Africa: Systematic Review
Mudzengi D, Chomutare H, Nagudi J, Ntshiqa T, Davis J, Charalambous S, Velen K. Using mHealth Technologies for Case Finding in Tuberculosis and Other Infectious Diseases in Africa: Systematic Review. JMIR MHealth And UHealth 2024, 12: e53211. PMID: 39186366, PMCID: PMC11384173, DOI: 10.2196/53211.Peer-Reviewed Original ResearchLeveraging technology to improve access to medical education in anatomy and physiology in resource‐limited settings: A mixed methods study
Carpio A, Romero‐Reveron R, Vasquez M, Castillo J, Concepción L, Carrera R, Díaz D, Conde B, Montbrun M, Espinoza‐Luna A, Kreiger J, Davis J, Rochester C, Martin A. Leveraging technology to improve access to medical education in anatomy and physiology in resource‐limited settings: A mixed methods study. Anatomical Sciences Education 2024, 17: 1283-1298. PMID: 38954744, DOI: 10.1002/ase.2474.Peer-Reviewed Original ResearchShort video lecturesLatin American universitiesResource-limited settingsMixed methods designVideo-based interventionLevel of feasibilitySignificant knowledge gainsFlexible educationAsynchronous educationVideo lecturesMixed methods studyEducational impactPre/post-testMedical studentsAmerican universitiesGoogle DriveStudentsKnowledge gainQualitative dataEducationMethods designYear medical studentsLeveraging technologyLightboardQuantitative dataModeled estimates of HIV-serodifferent couples in tuberculosis-affected households in four sub-Saharan African countries
Zhang M, Tseng A, Anguzu G, Barnabas R, Davis J, Mujugira A, Flaxman A, Ross J. Modeled estimates of HIV-serodifferent couples in tuberculosis-affected households in four sub-Saharan African countries. PLOS Global Public Health 2024, 4: e0002609. PMID: 38696500, PMCID: PMC11065259, DOI: 10.1371/journal.pgph.0002609.Peer-Reviewed Original ResearchHIV serodifferent couplesTB-affected householdsSerodifferent couplesPrEP useSub-Saharan African countriesHIV acquisitionSouth AfricaGeneral populationHIV prevalencePopulation-based household surveyOral pre-exposure prophylaxisPre-exposure prophylaxisGlobal Burden of DiseaseHousehold surveyRisk Factors StudyAfrican countriesBurden of diseaseHouseholdsHigh-burden countriesContact evaluationPrEPGlobal burdenCountriesMeta-analysesTB-HIVSex and HIV Differences in Preserved Ratio Impaired Spirometry (PRISm) Among Ugandans Postpneumonia
Abelman R, Fitzpatrick J, Byanova K, Zawedde J, Sanyu I, Byanyima P, Musisi E, Hsieh J, Zhang M, Branchini J, Sessolo A, Hunt P, Lalitha R, Davis J, Crothers K, Worodria W, Huang L. Sex and HIV Differences in Preserved Ratio Impaired Spirometry (PRISm) Among Ugandans Postpneumonia. Open Forum Infectious Diseases 2024, 11: ofae033. PMID: 38456193, PMCID: PMC10919919, DOI: 10.1093/ofid/ofae033.Peer-Reviewed Original ResearchPreserved ratio impaired spirometryAssociated with increased oddsFemale sexAssociated with lower oddsBiomass fuel exposureAssociated with increased mortalityBaseline participantsLower oddsDecreased oddsHIV statusPost-pneumoniaIncreased oddsGeneral populationImpaired spirometryLung function abnormalitiesFuel exposureIncreased riskEffects of sexTB statusHIVLow FEV1Normal spirometryParticipantsHIV effectsSpirometry
2023
The feasibility, acceptability, and preliminary impact of real-time monitors and SMS on tuberculosis medication adherence in southwestern Uganda: Findings from a mixed methods pilot randomized controlled trial
Musiimenta A, Tumuhimbise W, Atukunda E, Mugaba A, Musinguzi N, Muzoora C, Bangsberg D, Davis J, Haberer J. The feasibility, acceptability, and preliminary impact of real-time monitors and SMS on tuberculosis medication adherence in southwestern Uganda: Findings from a mixed methods pilot randomized controlled trial. PLOS Global Public Health 2023, 3: e0001813. PMID: 38051699, PMCID: PMC10697590, DOI: 10.1371/journal.pgph.0001813.Peer-Reviewed Original ResearchMedication adherenceControl armAcceptability dataTB medication adherenceTuberculosis medication adherenceDrug-sensitive tuberculosisDaily SMSMixed-methods pilotWeekly SMSElectronic adherence monitorsTB patientsMedian ageMonth 6Primary outcomeClinical outcomesMedian adherencePercent adherencePercentage adherenceSMS remindersStatus disclosureAdherence monitorsAdherence dataAdherence patternsRegistration numberMethods pilotGeographic distribution and predictors of diagnostic delays among possible TB patients in Uganda
Ochom E, Robsky K, Gupta A, Tamale A, Kungu J, Turimumahoro P, Nakasendwa S, Rwego I, Muttamba W, Joloba M, Ssengooba W, Davis J, Katamba A. Geographic distribution and predictors of diagnostic delays among possible TB patients in Uganda. Public Health Action 2023, 13: 70-76. PMID: 37736583, PMCID: PMC10446659, DOI: 10.5588/pha.23.0010.Peer-Reviewed Original ResearchHealth system delayPatient delayTB evaluationDiagnostic delayHealth system-related delaysSystem-related delaysTB diagnostic delayMultivariate logistic regressionTB knowledgeTB patientsTB diagnosisPatient outcomesSecondary analysisLogistic regressionGlobal Moran's IMarital statusPatientsAdultsPredictorsIndividual predictorsMarried individualsIndividual factorsGeographic hotspotsYearsDiagnosisA user-centred implementation strategy for tuberculosis contact investigation in Uganda: protocol for a stepped-wedge, cluster-randomised trial
Katamba A, Gupta A, Turimumahoro P, Ochom E, Ggita J, Nakasendwa S, Nanziri L, Musinguzi J, Hennein R, Sekadde M, Hanrahan C, Byaruhanga R, Yoeli E, Turyahabwe S, Cattamanchi A, Dowdy D, Haberer J, Armstrong-Hough M, Kiwanuka N, Davis J. A user-centred implementation strategy for tuberculosis contact investigation in Uganda: protocol for a stepped-wedge, cluster-randomised trial. BMC Public Health 2023, 23: 1568. PMID: 37592314, PMCID: PMC10436440, DOI: 10.1186/s12889-023-16510-0.Peer-Reviewed Original ResearchConceptsContact investigationClinical effectiveness outcomesPrimary implementation outcomeTB contact investigationTB preventative therapyTB treatment initiationTimely TB diagnosisTrial registrationThe trialTuberculosis contact investigationCluster-randomised trialHigh-burden settingsImplementation-effectiveness trialEvidence-based interventionsUganda National CouncilWorld Health OrganizationProportion of contactsTB evaluationPeer-reviewed journalsMiddle-income countriesTreatment initiationTB diagnosisPreventative therapyUndiagnosed personsInfectious deathSputum samplesExploring stakeholders perspectives on TB contact investigation in Cali, Colombia: a qualitative study
Velosa J, Gómez J, Zúñiga C, Díaz G, Ferro B, Davis J, Grau L. Exploring stakeholders perspectives on TB contact investigation in Cali, Colombia: a qualitative study. Frontiers In Public Health 2023, 11: 1204862. PMID: 37564424, PMCID: PMC10411903, DOI: 10.3389/fpubh.2023.1204862.Peer-Reviewed Original ResearchConceptsTB contact investigationContact investigationPublic health staffHealth workersHousehold contactsTB knowledgeTB casesTest uptakeHealth staffHousehold visitsHealth OrganizationTuberculosis case findingNational public health authoritiesPublic health authoritiesWorld Health OrganizationPublic health organizationsMiddle-income countriesTB controlCase findingThematic analysisHealth authoritiesDiagnostic testsInductive thematic analysisSemi-structured interviewsMain barriersmHealth to improve implementation of TB contact investigation: a case study from Uganda
Gupta A, Turimumahoro P, Ochom E, Ggita J, Babirye D, Ayakaka I, Mark D, Okello D, Cattamanchi A, Dowdy D, Haberer J, Armstrong-Hough M, Katamba A, Davis J. mHealth to improve implementation of TB contact investigation: a case study from Uganda. Implementation Science Communications 2023, 4: 71. PMID: 37340456, PMCID: PMC10280918, DOI: 10.1186/s43058-023-00448-w.Peer-Reviewed Original ResearchTB contact investigationContact investigationHybrid implementation-effectiveness trialImplementation-effectiveness trialLocal public health partnersPublic health partnersElectronic decision supportImplementation scienceGlobal health studiesCommunity-engaged approachUsual careHIV testingMiddle-income countriesPublic health outcomesMulti-disciplinary teamImplementation trialHealth StudyHealth outcomesHealth settingsImplementation strategiesMHealth strategiesHealth partnersLow-income countriesImplementation researchGlobal health settingsSex modifies the risk of HIV-associated obstructive lung disease in Ugandans postpneumonia
Abelman R, Fitzpatrick J, Zawedde J, Sanyu I, Byanyima P, Kaswabuli S, Musisi E, Hsieh J, Gardner K, Zhang M, Byanova K, Sessolo A, Hunt P, Lalitha R, Davis J, Crothers K, Worodria W, Huang L. Sex modifies the risk of HIV-associated obstructive lung disease in Ugandans postpneumonia. AIDS 2023, 37: 1683-1692. PMID: 37352494, PMCID: PMC10527596, DOI: 10.1097/qad.0000000000003626.Peer-Reviewed Original ResearchConceptsObstructive lung diseaseLung diseaseLung functionAbnormal lung functionMultivariable regression modelsWarrants further studyCommon comorbiditiesExpiratory volumeSpirometric abnormalitiesSmoking statusSpirometric testingTB statusVital capacitySex modifiesStratified analysisHIVWomenDiseaseComorbiditiesMenSexFurther studiesGreater degreeRiskTuberculosisFrequency of HIV serodifferent couples within TB-affected households in a setting with a high burden of HIV-associated TB
Anguzu G, Gupta A, Ochom E, Tseng A, Zhang M, Barnabas R, Flaxman A, Katamba A, Davis J, Ross J. Frequency of HIV serodifferent couples within TB-affected households in a setting with a high burden of HIV-associated TB. BMC Infectious Diseases 2023, 23: 388. PMID: 37296396, PMCID: PMC10251627, DOI: 10.1186/s12879-023-08365-y.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusUganda AIDS Indicator SurveyHIV prevention servicesIndex participantsContact investigationGeneral populationPrevention servicesFrequency of HIVProportion of HIVRisk of HIVSelf-reported HIV statusHIV testing resultsHIV-serodifferent couplesHousehold contact investigationTB contact investigationAIDS Indicator SurveyCross-sectional trialCommunity health workersIndex partnerSerodifferent couplesTB evaluationHousehold contactsHomes of participantsHIV statusImmunodeficiency virusWomen Have Higher Risk Than Men for Preserved Ratio Impaired Spirometry (PRISm) Among Ugandans With HIV
Abelman R, Fitzpatrick J, Byanova K, Zawedde J, Sanyu I, Byanyima P, Kaswabuli S, Musisi E, Hsieh J, Zhang M, Branchini J, Sessolo A, Hunt P, Lin J, Lalitha R, Davis J, Crothers K, Woodruff P, Worodria W, Huang L. Women Have Higher Risk Than Men for Preserved Ratio Impaired Spirometry (PRISm) Among Ugandans With HIV. 2023, a6736-a6736. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6736.Peer-Reviewed Original ResearchMachine Learning Prediction of Severe Asthma and COPD Hospital Readmission
Li H, Lopez K, Lipkin-Moore Z, Kay S, Rajeevan H, Davis J, Wilson F, Rochester C, Gomez J. Machine Learning Prediction of Severe Asthma and COPD Hospital Readmission. 2023, a4831-a4831. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4831.Peer-Reviewed Original ResearchTelomere Length and Telomerase Activity Are Associated With COPD and Lung Function Abnormalities in Persons Living With HIV
Chang-Huang S, Fitzpatrick J, Dai G, Zhang M, Branchini J, Lin C, Huang P, Jan A, Huang C, Wu C, Hsieh J, Smith D, Abelman R, Byanova K, Wang R, Davis J, Crothers K, Hunt P, Segal M, Blackburn E, Lin J, Huang L. Telomere Length and Telomerase Activity Are Associated With COPD and Lung Function Abnormalities in Persons Living With HIV. 2023, a1137-a1137. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1137.Peer-Reviewed Original ResearchImplementation of a Hardware-Assisted Bluetooth-Based COVID-19 Tracking Device in a High School: Mixed Methods Study
Li D, Shelby T, Brault M, Manohar R, Vermund S, Hagaman A, Forastiere L, Caruthers T, Egger E, Wang Y, Manohar N, Manohar P, Davis J, Zhou X. Implementation of a Hardware-Assisted Bluetooth-Based COVID-19 Tracking Device in a High School: Mixed Methods Study. JMIR Formative Research 2023, 7: e39765. PMID: 36525333, PMCID: PMC10131711, DOI: 10.2196/39765.Peer-Reviewed Original ResearchContact tracingPilot implementation studyPublic health toolMixed-methods evaluationTechnical difficultiesSignificant numberQualitative focus group discussionsClose contactInfectious diseasesHealth toolsLarge-scale pandemicMixed-methods studyImplementation outcomesCOVID-19Significant differencesImplementation studyEmotional reassuranceFocus group discussionsMost contactMixed methods designMethods studySustained useCase interviewsMaintenance frameworkHabits