2015
Clinical and Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in a Neonatal Intensive Care Unit in the Decade following Implementation of an Active Detection and Isolation Program
Nelson MU, Bizzarro MJ, Baltimore RS, Dembry LM, Gallagher PG. Clinical and Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in a Neonatal Intensive Care Unit in the Decade following Implementation of an Active Detection and Isolation Program. Journal Of Clinical Microbiology 2015, 53: 2492-2501. PMID: 26019206, PMCID: PMC4508396, DOI: 10.1128/jcm.00470-15.Peer-Reviewed Original ResearchMeSH KeywordsDNA, BacterialEpidemiological MonitoringFemaleGenetic VariationGenotypeGenotyping TechniquesHumansInfantInfant, NewbornIntensive Care Units, NeonatalMaleMethicillin-Resistant Staphylococcus aureusMolecular EpidemiologyMolecular TypingRetrospective StudiesStaphylococcal InfectionsVirulence FactorsConceptsNeonatal intensive care unitMethicillin-resistant Staphylococcus aureusIntensive care unitMRSA colonizationMolecular epidemiologyCare unitStaphylococcal cassette chromosome mec type IIAccessory gene regulator (agr) groupsMRSA colonization rateToxic shock syndrome toxinAgr group 1Exfoliative toxin AStaphylococcus aureusPotential virulence factor genesVirulence factor genesMRSA infectionSignificant morbidityClinical differencesPatient daysPulsed-field gel electrophoresisToxin AUSA300 strainGroup 1Continued vigilanceInfectionNeonatal Sepsis 2004-2013: The Rise and Fall of Coagulase-Negative Staphylococci
Bizzarro MJ, Shabanova V, Baltimore RS, Dembry LM, Ehrenkranz RA, Gallagher PG. Neonatal Sepsis 2004-2013: The Rise and Fall of Coagulase-Negative Staphylococci. The Journal Of Pediatrics 2015, 166: 1193-1199. PMID: 25919728, PMCID: PMC4413005, DOI: 10.1016/j.jpeds.2015.02.009.Peer-Reviewed Original ResearchConceptsEarly-onset sepsisLate-onset sepsisNeonatal intensive care unitCoagulase-negative staphylococciIntensive care unitCare unitLevel IV neonatal intensive care unitEpisodes of sepsisLow birth weightInfection prevention initiativesInfection prevention effortsPercent of casesGroup B streptococciHospital courseSepsis episodesMost infantsBirth weightCommon organismB streptococciSepsisOutcome dataAdditional surveillancePrevention effortsStudy periodInfants
2014
One size does not fit all: why universal decolonization strategies to prevent methicillin-resistant Staphylococcus aureus colonization and infection in adult intensive care units may be inappropriate for neonatal intensive care units
Nelson MU, Bizzarro MJ, Dembry LM, Baltimore RS, Gallagher PG. One size does not fit all: why universal decolonization strategies to prevent methicillin-resistant Staphylococcus aureus colonization and infection in adult intensive care units may be inappropriate for neonatal intensive care units. Journal Of Perinatology 2014, 34: 653-655. PMID: 25010223, PMCID: PMC4152419, DOI: 10.1038/jp.2014.125.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitIntensive care unitAdult intensive care unitsCare unitUniversal decolonizationMethicillin-resistant Staphylococcus aureus (MRSA) colonizationMRSA-positive clinical cultureUnique patient populationLarge multicenter trialsStaphylococcus aureus colonizationLong-term safetyMupirocin applicationAdverse eventsPreterm infantsLarge multicenterMulticenter trialPatient populationAureus colonizationDecolonization strategiesClinical culturesDisease controlHealthcare ResearchTrialsTrial methodsWidespread implementation
2011
Granulicatella adiacens and Early-Onset Sepsis in Neonate - Volume 17, Number 10—October 2011 - Emerging Infectious Diseases journal - CDC
Bizzarro MJ, Callan DA, Farrel PA, Dembry LM, Gallagher PG. Granulicatella adiacens and Early-Onset Sepsis in Neonate - Volume 17, Number 10—October 2011 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2011, 17: 1971-1973. PMID: 22000391, PMCID: PMC3310662, DOI: 10.3201/eid1710.101967.Peer-Reviewed Original Research
2008
Matched Case-Control Analysis of Polymicrobial Bloodstream Infection In A Neonatal Intensive Care Unit
Bizzarro MJ, Dembry LM, Baltimore RS, Gallagher PG. Matched Case-Control Analysis of Polymicrobial Bloodstream Infection In A Neonatal Intensive Care Unit. Infection Control And Hospital Epidemiology 2008, 29: 914-920. PMID: 18808341, DOI: 10.1086/591323.Peer-Reviewed Original ResearchMeSH KeywordsBacteremiaCase-Control StudiesFemaleFungemiaFungiGram-Negative BacteriaGram-Negative Bacterial InfectionsGram-Positive BacteriaGram-Positive Bacterial InfectionsHumansIncidenceInfant, Low Birth WeightInfant, NewbornInfant, PrematureInfant, Premature, DiseasesInfant, Very Low Birth WeightIntensive Care Units, NeonatalMaleRisk FactorsConceptsPolymicrobial bloodstream infectionsMonomicrobial bloodstream infectionSevere underlying conditionsBloodstream infectionsOnset of infectionUnderlying conditionRisk factorsMultivariate analysisIndwelling central venous catheterIntensive care unit patientsNeonatal intensive care unitMatched Case-Control AnalysisIndependent risk factorNewborn intensive care unit (NICU) patientsCare unit patientsCentral venous cathetersIntensive care unitNeonatal bloodstream infectionsMost risk factorsCase-control studyCase-control analysisCoagulase-negative staphylococciHospital NICUUnit patientsVenous cathetersChanging Patterns in Neonatal Escherichia coli Sepsis and Ampicillin Resistance in the Era of Intrapartum Antibiotic Prophylaxis
Bizzarro MJ, Dembry LM, Baltimore RS, Gallagher PG. Changing Patterns in Neonatal Escherichia coli Sepsis and Ampicillin Resistance in the Era of Intrapartum Antibiotic Prophylaxis. Pediatrics 2008, 121: 689-696. PMID: 18381532, DOI: 10.1542/peds.2007-2171.Peer-Reviewed Original ResearchMeSH KeywordsAmpicillinAmpicillin ResistanceAntibiotic ProphylaxisBacteremiaEscherichia coliEscherichia coli InfectionsFemaleFollow-Up StudiesHumansIncidenceInfant, NewbornInfectious Disease Transmission, VerticalMaleMultivariate AnalysisOdds RatioPregnancyPregnancy Complications, InfectiousPrenatal CareProbabilityRetrospective StudiesRisk AssessmentSeverity of Illness IndexStatistics, NonparametricSurvival RateConceptsE. coli early-onset sepsisEarly-onset sepsisLate-onset sepsisYale-New Haven HospitalIntrapartum antibiotic prophylaxisAntibiotic prophylaxisColi sepsisLow birth weight infantsAmpicillin resistanceAntibiotic prophylaxis practiceIntrapartum antibiotic exposureBirth weight infantsE. coli sepsisIndependent risk factorEscherichia coli sepsisAmpicillin exposureAmpicillin-resistant E. coliProphylaxis practicesSepsis rateWeight infantsNeonatal sepsisPreterm infantsTerm infantsRetrospective reviewRisk factors
2007
Trends in Prescribing β-Lactam Antibiotics for Treatment of Community-Associated Methicillin-Resistant Staphylococcus aureus Infections
Gupta K, MacIntyre A, Vanasse G, Dembry LM. Trends in Prescribing β-Lactam Antibiotics for Treatment of Community-Associated Methicillin-Resistant Staphylococcus aureus Infections. Journal Of Clinical Microbiology 2007, 45: 3930-3934. PMID: 17942648, PMCID: PMC2168566, DOI: 10.1128/jcm.01510-07.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnti-Bacterial AgentsBeta-LactamsChildChild, PreschoolCommunity-Acquired InfectionsDrug PrescriptionsFemaleHealth Services ResearchHumansInfantInfant, NewbornMaleMethicillin ResistanceMiddle AgedPrevalenceStaphylococcal InfectionsStaphylococcus aureusUnited StatesConceptsCA-MRSA soft tissue infectionsSoft tissue infectionsInitial empirical therapyCA-MRSA isolatesEmpirical therapyAntimicrobial therapyCommunity-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) isolatesStaphylococcal chromosomal cassette mec type IVS. aureus soft tissue infectionsResistant Staphylococcus aureus infectionsMethicillin-Resistant Staphylococcus aureus IsolatesInactive antimicrobial therapyRate of prescribingCA-MRSA infectionsInitial antimicrobial therapyMajority of patientsMedical record reviewSubset of patientsCommunity-Associated MethicillinStaphylococcus aureus infectionPanton-Valentine leukocidinStaphylococcus aureus isolatesBeta-lactam antibioticsDiscordant therapyRate of useCase-control analysis of endemic Serratia marcescens bacteremia in a neonatal intensive care unit
Bizzarro MJ, Dembry LM, Baltimore RS, Gallagher PG. Case-control analysis of endemic Serratia marcescens bacteremia in a neonatal intensive care unit. Archives Of Disease In Childhood - Fetal And Neonatal Edition 2007, 92: f120. PMID: 17088342, PMCID: PMC2675455, DOI: 10.1136/adc.2006.102855.Peer-Reviewed Original ResearchMeSH KeywordsBacteremiaBirth WeightCase-Control StudiesConnecticutCross InfectionDrug Resistance, BacterialEndemic DiseasesEscherichia coliEscherichia coli InfectionsFemaleHumansInfant, NewbornIntensive Care Units, NeonatalMaleMicrobial Sensitivity TestsPrognosisRisk FactorsSerratia InfectionsSerratia marcescensConceptsNeonatal intensive care unitIntensive care unitCare unitUninfected controlsHospital Neonatal Intensive Care UnitSerratia marcescens bacteremiaMedian gestational ageCentral vascular catheterEscherichia coli bacteremiaRecords of infantsCase-control studyHigher overall mortalityE coliOnset of infectionCase-control analysisTime of infectionHigh rateAssociated meningitisHospital courseColi bacteremiaOverall mortalityGestational agePremature infantsVascular cathetersBirth weight
2005
Vancomycin-Resistant Enterococcal Bacteremia and Necrotizing Enterocolitis in a Preterm Neonate
Raskind CH, Dembry LM, Gallagher PG. Vancomycin-Resistant Enterococcal Bacteremia and Necrotizing Enterocolitis in a Preterm Neonate. The Pediatric Infectious Disease Journal 2005, 24: 943-944. PMID: 16220106, DOI: 10.1097/01.inf.0000180987.00122.5d.Peer-Reviewed Original Research
2004
Conjunctival Colonization of Infants Hospitalized in a Neonatal Intensive Care Unit: A Longitudinal Analysis
Raskind CH, Sabo BE, Callan DA, Farrel PA, Dembry LM, Gallagher PG. Conjunctival Colonization of Infants Hospitalized in a Neonatal Intensive Care Unit: A Longitudinal Analysis. Infection Control And Hospital Epidemiology 2004, 25: 216-220. PMID: 15061413, DOI: 10.1086/502381.Peer-Reviewed Original Research
2000
Molecular Typing Demonstrating Transmission of Gram-Negative Rods in a Neonatal Intensive Care Unit in the Absence of a Recognized Epidemic
Almuneef M, Baltimore R, Farrel P, Reagan-Cirincione P, Dembry L. Molecular Typing Demonstrating Transmission of Gram-Negative Rods in a Neonatal Intensive Care Unit in the Absence of a Recognized Epidemic. Clinical Infectious Diseases 2000, 32: 220-227. PMID: 11170911, DOI: 10.1086/318477.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBacterial Typing TechniquesCross InfectionDNA, BacterialDrug Resistance, MicrobialElectrophoresisFecesFemaleGenotypeGentamicinsGram-Negative Aerobic Rods and CocciGram-Negative Bacterial InfectionsHumansInfantInfant, NewbornIntensive Care Units, NeonatalMaleMicrobial Sensitivity TestsConceptsNeonatal intensive care unitIntensive care unitShared strainsCare unitMolecular typing techniquesRectal swab culturesColonization of infantsGentamicin-resistant strainsWeeks of ageTyping techniquesAntibiotic treatmentAntibiotic useSwab culturesGram-negative rodsGentamicin susceptibilityInfantsTotal daysOutbreak investigationIdentical strainsNegative rodsUnique strainsHigh rateContour-clamped homogeneous electric field electrophoresisAdmissionGentamicin
1999
A Decade of Prevalence Surveys in a Tertiary-Care Center: Trends in Nosocomial Infection Rates, Device Utilization, and Patient Acuity
Weinstein J, Mazon D, Pantelick E, Reagan-Cirincione P, Dembry L, Hierholzer W. A Decade of Prevalence Surveys in a Tertiary-Care Center: Trends in Nosocomial Infection Rates, Device Utilization, and Patient Acuity. Infection Control And Hospital Epidemiology 1999, 20: 543-548. PMID: 10466554, DOI: 10.1086/501675.Peer-Reviewed Original ResearchConceptsNosocomial infection ratesAcute care patientsNosocomial bloodstream infectionsPrevalence surveyNosocomial infectionsInfection rateBloodstream infectionsPotential quality improvement initiativesAbnormal laboratory indicatorsAnnual prevalence surveysInvasive device utilizationTertiary care centerAbnormal laboratory valuesSeverity of illnessAcute care bedsInfection control practitionersSurveillance System dataRate of infectionQuality improvement initiativesObstetric-gynecologic servicesCase mix indexChart reviewCare patientsFoley catheterLaboratory indicators