2023
Plasma renalase levels are associated with the development of acute pancreatitis
Wang M, Weiss F, Guo X, Kolodecik T, Bewersdorf J, Laine L, Lerch M, Desir G, Gorelick F. Plasma renalase levels are associated with the development of acute pancreatitis. Pancreatology 2023, 23: 158-162. PMID: 36697349, DOI: 10.1016/j.pan.2023.01.001.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsHumansMiceMonoamine OxidasePancreatitisPrognosisSeverity of Illness IndexConceptsAcute pancreatitisSevere diseasePlasma renalase levelsAcute pancreatitis patientsSevere acute pancreatitisAcute pancreatitis modelPlasma renalaseRenalase levelsSignificant morbidityPancreatitis patientsPlasma levelsHealthy controlsPancreatitis modelPancreatitisPatientsPlasma samplesRenalaseDiseaseNonparametric statistical analysisSecretory proteinsMorbidityStatistical analysisMortalityLevels
2021
Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies
Muniraj T, Aslanian HR, Laine L, Jamidar PA, Farrell JF, Mitchell KA, Salem RR. Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies. World Journal Of Gastroenterology 2021, 27: 1630-1642. PMID: 33958848, PMCID: PMC8058652, DOI: 10.3748/wjg.v27.i15.1630.Peer-Reviewed Original ResearchConceptsIntra-ductal papillary mucinous neoplasmRecurrent acute pancreatitisPancreatic cystic neoplasmsCystic neoplasmsBD-IPMNAcute pancreatitisCause of pancreatitisRole of resectionMucinous cystic neoplasmPrevalence of malignancyPapillary mucinous neoplasmSerous cystic neoplasmsCross-sectional imagingMean episodesRAP patientsSurgical resectionCyst resectionMD-IPMNPrimary outcomeIPMN patientsRecurrent pancreatitisRetrospective studyCyst featuresGallstone aetiologyMucinous neoplasms
2017
Randomized trial of cholangioscopy-guided laser lithotripsy versus conventional therapy for large bile duct stones (with videos)
Buxbaum J, Sahakian A, Ko C, Jayaram P, Lane C, Yu CY, Kankotia R, Laine L. Randomized trial of cholangioscopy-guided laser lithotripsy versus conventional therapy for large bile duct stones (with videos). Gastrointestinal Endoscopy 2017, 87: 1050-1060. PMID: 28866457, DOI: 10.1016/j.gie.2017.08.021.Peer-Reviewed Original ResearchConceptsCholangioscopy-guided laser lithotripsyBile duct stonesDuct stonesConventional therapyLaser lithotripsy groupEndoscopic clearanceMechanical lithotripsyBalloon dilationLaser lithotripsyLithotripsy groupProcedure timeLarge common bile duct stonesCommon bile duct stonesLarge bile duct stonesConventional therapy groupHistory of ERCPCommon duct explorationPost-ERCP pancreatitisLarge bile ductsCholangioscopy-guided lithotripsyLonger procedure timeSuccessful endoscopic extractionNumber of proceduresAdverse eventsDuct explorationEarly Aggressive Hydration Hastens Clinical Improvement in Mild Acute Pancreatitis
Buxbaum JL, Quezada M, Da B, Jani N, Lane C, Mwengela D, Kelly T, Jhun P, Dhanireddy K, Laine L. Early Aggressive Hydration Hastens Clinical Improvement in Mild Acute Pancreatitis. The American Journal Of Gastroenterology 2017, 112: 797. PMID: 28266591, DOI: 10.1038/ajg.2017.40.Peer-Reviewed Original ResearchConceptsSystemic inflammatory response syndromeMild acute pancreatitisBlood urea nitrogenAggressive intravenous hydrationClinical improvementStandard hydrationAcute pancreatitisIntravenous hydrationPersistent systemic inflammatory response syndromeClear liquid dietInflammatory response syndromeCox regression analysisAcute pancreatitis treatmentLactated Ringer's solutionAggressive hydrationEpigastric painImproved painOral dietPrimary endpointInitial managementOrgan failureResponse syndromeRandomized trialsVolume overloadMean age
2016
Randomized Trial of Endoscopist-Controlled vs. Assistant-Controlled Wire-Guided Cannulation of the Bile Duct
Buxbaum J, Leonor P, Tung J, Lane C, Sahakian A, Laine L. Randomized Trial of Endoscopist-Controlled vs. Assistant-Controlled Wire-Guided Cannulation of the Bile Duct. The American Journal Of Gastroenterology 2016, 111: 1841. PMID: 27377519, DOI: 10.1038/ajg.2016.268.Peer-Reviewed Original ResearchMeSH KeywordsAdultBile DuctsCatheterizationCholangiopancreatography, Endoscopic RetrogradeCholangitisEarly Termination of Clinical TrialsFemaleGastroenterologistsHemorrhageHumansIntraoperative ComplicationsLogistic ModelsMaleMiddle AgedMultivariate AnalysisNursesPancreatitisPatient SafetyPostoperative ComplicationsPostoperative HemorrhageConceptsBile duct cannulationEndoscopic retrograde cholangiopancreatographySafety end pointDuct cannulationBiliary cannulationInterim analysisWire guidanceComposite safety end pointComplications of ERCPEnd pointPrimary efficacy outcomePost-ERCP pancreatitisSuccessful biliary cannulationSignificant differencesEfficacy outcomesRandomized trialsBile ductRetrograde cholangiopancreatographyCannulation attemptsCannulationPatientsSphincterotomePancreatitisSignificant increaseLower rates
2013
Aggressive Hydration With Lactated Ringer's Solution Reduces Pancreatitis After Endoscopic Retrograde Cholangiopancreatography
Buxbaum J, Yan A, Yeh K, Lane C, Nguyen N, Laine L. Aggressive Hydration With Lactated Ringer's Solution Reduces Pancreatitis After Endoscopic Retrograde Cholangiopancreatography. Clinical Gastroenterology And Hepatology 2013, 12: 303-307.e1. PMID: 23920031, PMCID: PMC3879172, DOI: 10.1016/j.cgh.2013.07.026.Peer-Reviewed Original ResearchConceptsEndoscopic retrograde cholangiopancreatographyPost-ERCP pancreatitisAggressive hydrationStandard hydrationVolume overloadEpigastric painRetrograde cholangiopancreatographyRinger's solutionFirst-time endoscopic retrograde cholangiopancreatographyVisual analogue pain scoreEnd pointPilot studyAggressive intravenous hydrationAnalog pain scoresIncidence of pancreatitisPrimary end pointSecondary end pointsCommon serious complicationLactated Ringer's solutionPeriprocedural hydrationIntravenous hydrationPain scoresSerious complicationsSerum levelsPancreatitis