2022
Vonoprazan Versus Lansoprazole for Healing and Maintenance of Healing of Erosive Esophagitis: A Randomized Trial
Laine L, DeVault K, Katz P, Mitev S, Lowe J, Hunt B, Spechler S. Vonoprazan Versus Lansoprazole for Healing and Maintenance of Healing of Erosive Esophagitis: A Randomized Trial. Gastroenterology 2022, 164: 61-71. PMID: 36228734, DOI: 10.1053/j.gastro.2022.09.041.Peer-Reviewed Original ResearchMeSH KeywordsAdultEsophagitisHumansLansoprazolePeptic UlcerProton Pump InhibitorsPyrrolesSulfonamidesTreatment OutcomeConceptsMaintenance of healingProton pump inhibitorsErosive esophagitisSecondary analysisD esophagitisPrimary analysisEnd pointPotassium-competitive acid blocker vonoprazanHeartburn-free daysSevere erosive esophagitisMainstay of treatmentPrimary end pointSecondary end pointsPotent acid inhibitionPPI lansoprazolePump inhibitorsEsophagitisNoninferiority comparisonVonoprazanWeek 2Healing phaseAbstractTextPatientsLansoprazoleSuperiority analysisVonoprazan Triple and Dual Therapy for Helicobacter pylori Infection in the United States and Europe: Randomized Clinical Trial
Chey WD, Mégraud F, Laine L, López LJ, Hunt BJ, Howden CW. Vonoprazan Triple and Dual Therapy for Helicobacter pylori Infection in the United States and Europe: Randomized Clinical Trial. Gastroenterology 2022, 163: 608-619. PMID: 35679950, DOI: 10.1053/j.gastro.2022.05.055.Peer-Reviewed Original ResearchConceptsEradication rateHelicobacter pylori infectionTriple therapyDual therapyPylori infectionProton pump inhibitor-based triple therapyTreatment-emergent adverse eventsInhibitor-based triple therapyPotassium-competitive acid blockerEfficacy of vonoprazanH pylori eradicationPhase 3 trialOverall study populationAmoxicillin-resistant strainsClarithromycin-resistant strainsH pylori infectionTreatment-naïve adultsPylori eradicationAdverse eventsSecondary outcomesPrimary outcomeStandard treatmentClinical trialsStudy populationAcid blocker
2020
Fecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry
Kelly CR, Yen EF, Grinspan AM, Kahn SA, Atreja A, Lewis JD, Moore TA, Rubin DT, Kim AM, Serra S, Nersesova Y, Fredell L, Hunsicker D, McDonald D, Knight R, Allegretti JR, Pekow J, Absah I, Hsu R, Vincent J, Khanna S, Tangen L, Crawford CV, Mattar MC, Chen LA, Fischer M, Arsenescu RI, Feuerstadt P, Goldstein J, Kerman D, Ehrlich AC, Wu GD, Laine L. Fecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry. Gastroenterology 2020, 160: 183-192.e3. PMID: 33011173, PMCID: PMC8034505, DOI: 10.1053/j.gastro.2020.09.038.Peer-Reviewed Original ResearchConceptsClostridioides difficile infectionMicrobiota transplantationSafety profileNational registryProspective real-world studyFull safety profileProspective safety dataBaseline patient characteristicsInflammatory bowel diseaseIrritable bowel syndromeFecal microbiota transplantationLong-term safety outcomesGood safety profileReal-world studyAbdominal painBowel syndromePatient characteristicsReal-world practiceBowel diseaseCDI recurrenceDifficile infectionSafety dataSafety outcomesEffectiveness outcomesSevere symptoms
2019
Machine Learning to Predict Outcomes in Patients with Acute Gastrointestinal Bleeding: A Systematic Review
Shung D, Simonov M, Gentry M, Au B, Laine L. Machine Learning to Predict Outcomes in Patients with Acute Gastrointestinal Bleeding: A Systematic Review. Digestive Diseases And Sciences 2019, 64: 2078-2087. PMID: 31055722, DOI: 10.1007/s10620-019-05645-z.Peer-Reviewed Original ResearchConceptsClinical risk scoreUpper gastrointestinal bleedingGastrointestinal bleedingOutcomes of mortalityRisk scoreSystematic reviewOvert gastrointestinal bleedingAcute gastrointestinal bleedingPrognosis Studies toolRisk of biasFull-text studiesCurrent risk assessment toolsRisk assessment toolHospital stayHemostatic interventionRisk stratificationInclusion criteriaPrognostic performanceHigh riskIndependent reviewersConference abstractsLower riskMedian AUCPatientsMortality
2017
Randomized trial of cholangioscopy-guided laser lithotripsy versus conventional therapy for large bile duct stones (with videos)
Buxbaum J, Sahakian A, Ko C, Jayaram P, Lane C, Yu CY, Kankotia R, Laine L. Randomized trial of cholangioscopy-guided laser lithotripsy versus conventional therapy for large bile duct stones (with videos). Gastrointestinal Endoscopy 2017, 87: 1050-1060. PMID: 28866457, DOI: 10.1016/j.gie.2017.08.021.Peer-Reviewed Original ResearchConceptsCholangioscopy-guided laser lithotripsyBile duct stonesDuct stonesConventional therapyLaser lithotripsy groupEndoscopic clearanceMechanical lithotripsyBalloon dilationLaser lithotripsyLithotripsy groupProcedure timeLarge common bile duct stonesCommon bile duct stonesLarge bile duct stonesConventional therapy groupHistory of ERCPCommon duct explorationPost-ERCP pancreatitisLarge bile ductsCholangioscopy-guided lithotripsyLonger procedure timeSuccessful endoscopic extractionNumber of proceduresAdverse eventsDuct explorationOptimal Timing of Endoscopic Retrograde Cholangiopancreatography in Acute Cholangitis
Hou LA, Laine L, Motamedi N, Sahakian A, Lane C, Buxbaum J. Optimal Timing of Endoscopic Retrograde Cholangiopancreatography in Acute Cholangitis. Journal Of Clinical Gastroenterology 2017, 51: 534-538. PMID: 27875357, DOI: 10.1097/mcg.0000000000000763.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdolescentAdultAgedAged, 80 and overCholangiopancreatography, Endoscopic RetrogradeCholangitisFemaleHospitalizationHumansIntensive Care UnitsIntubation, IntratrachealLength of StayMaleMiddle AgedMultivariate AnalysisProspective StudiesTime FactorsTreatment OutcomeYoung AdultConceptsEndoscopic retrograde cholangiopancreatographyIntensive care unit admissionCare unit admissionLength of hospitalizationAcute cholangitisUnit admissionRetrograde cholangiopancreatographyFrequent intensive care unit admissionOptimal timingAdditional adverse outcomesCases of cholangitisProcedural adverse eventsDays of presentationVasopressor requirementVasopressor supportBiliary decompressionHospital stayVasopressor useSecondary outcomesAdverse eventsAntibiotic therapyPrimary outcomeEndotracheal intubationAdverse outcomesEmergency departmentEarly Aggressive Hydration Hastens Clinical Improvement in Mild Acute Pancreatitis
Buxbaum JL, Quezada M, Da B, Jani N, Lane C, Mwengela D, Kelly T, Jhun P, Dhanireddy K, Laine L. Early Aggressive Hydration Hastens Clinical Improvement in Mild Acute Pancreatitis. The American Journal Of Gastroenterology 2017, 112: 797. PMID: 28266591, DOI: 10.1038/ajg.2017.40.Peer-Reviewed Original ResearchConceptsSystemic inflammatory response syndromeMild acute pancreatitisBlood urea nitrogenAggressive intravenous hydrationClinical improvementStandard hydrationAcute pancreatitisIntravenous hydrationPersistent systemic inflammatory response syndromeClear liquid dietInflammatory response syndromeCox regression analysisAcute pancreatitis treatmentLactated Ringer's solutionAggressive hydrationEpigastric painImproved painOral dietPrimary endpointInitial managementOrgan failureResponse syndromeRandomized trialsVolume overloadMean ageThe AGA’s Fecal Microbiota Transplantation National Registry: An Important Step Toward Understanding Risks and Benefits of Microbiota Therapeutics
Kelly CR, Kim AM, Laine L, Wu GD. The AGA’s Fecal Microbiota Transplantation National Registry: An Important Step Toward Understanding Risks and Benefits of Microbiota Therapeutics. Gastroenterology 2017, 152: 681-684. PMID: 28143773, DOI: 10.1053/j.gastro.2017.01.028.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2016
Histological Disease Activity as a Predictor of Clinical Relapse Among Patients With Ulcerative Colitis: Systematic Review and Meta-Analysis
Park S, Abdi T, Gentry M, Laine L. Histological Disease Activity as a Predictor of Clinical Relapse Among Patients With Ulcerative Colitis: Systematic Review and Meta-Analysis. The American Journal Of Gastroenterology 2016, 111: 1692. PMID: 27725645, DOI: 10.1038/ajg.2016.418.Peer-Reviewed Original ResearchConceptsRelapse/exacerbationHistological remissionEndoscopic remissionClinical remissionHistological activityClinical outcomesUlcerative colitisHistological statusClinical relapseHistological featuresLamina propriaChronic inflammatory cell infiltrateAdditional prognostic utilityHistological disease activityProportion of patientsInflammatory bowel diseaseInflammatory cell infiltrateLack of blindingImproved clinical outcomesDifferent histological featuresSpecific histological featuresRandom-effects modelFixed-effects modelDisease activityUC patientsRandomized trial of 1‐week versus 2‐week intervals for endoscopic ligation in the treatment of patients with esophageal variceal bleeding
Sheibani S, Khemichian S, Kim JJ, Hou L, Yan AW, Buxbaum J, Dara L, Laine L. Randomized trial of 1‐week versus 2‐week intervals for endoscopic ligation in the treatment of patients with esophageal variceal bleeding. Hepatology 2016, 64: 549-555. PMID: 27082942, PMCID: PMC4956532, DOI: 10.1002/hep.28597.Peer-Reviewed Original ResearchConceptsEsophageal variceal bleedingVariceal bleedingVariceal eradicationAcute esophageal variceal bleedingBeta-blocker therapyProportion of patientsTreatment of patientsNumber of endoscopiesMean numberLigation sessionsChest painPrimary endpointAdverse eventsClinical outcomesEndoscopic ligationLast endoscopyPhysician preferencePatientsBleedingSuccessful ligationEndoscopyConfidence intervalsEradicationLigationWeeksNo Benefit From Platelet Transfusion for Gastrointestinal Bleeding in Patients Taking Antiplatelet Agents
Zakko L, Rustagi T, Douglas M, Laine L. No Benefit From Platelet Transfusion for Gastrointestinal Bleeding in Patients Taking Antiplatelet Agents. Clinical Gastroenterology And Hepatology 2016, 15: 46-52. PMID: 27464591, DOI: 10.1016/j.cgh.2016.07.017.Peer-Reviewed Original ResearchConceptsGastrointestinal bleedingAntiplatelet agentsPlatelet transfusionsCardiovascular eventsNon-variceal upper gastrointestinal bleedingYale-New Haven HospitalRecurrent gastrointestinal bleedingSerious gastrointestinal bleedingMajor cardiovascular eventsRetrospective cohort studySevere gastrointestinal bleedingUpper gastrointestinal bleedingLower blood pressureMultivariable regression analysisHigher heart rateLack of benefitRecurrent bleedingBaseline characteristicsCohort studyBlood pressurePrimary outcomeSuch patientsHemoglobin levelsMultivariable analysisIntensive careEffect of Intragastric Balloons on Liver Enzymes: A Systematic Review and Meta-Analysis
Popov VB, Thompson CC, Kumar N, Ciarleglio MM, Deng Y, Laine L. Effect of Intragastric Balloons on Liver Enzymes: A Systematic Review and Meta-Analysis. Digestive Diseases And Sciences 2016, 61: 2477-2487. PMID: 27207181, DOI: 10.1007/s10620-016-4178-2.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseLiver enzymesIntragastric balloonMarkers of NAFLDEffective short-term treatmentIntragastric balloon placementObese adult patientsNAFLD activity scoreFatty liver diseaseStudy inclusion criteriaShort-term treatmentMagnetic resonance imagingResultsNine observational studiesBackgroundIntragastric balloonsIGB therapyBalloon insertionLiver testsAdult patientsBalloon therapyObese patientsBalloon removalActivity scoreLiver diseaseHepatic steatosisBalloon placementEfficacy and Safety of Proton-Pump Inhibitors in High-Risk Cardiovascular Subsets of the COGENT Trial
Vaduganathan M, Cannon CP, Cryer BL, Liu Y, Hsieh WH, Doros G, Cohen M, Lanas A, Schnitzer TJ, Shook TL, Lapuerta P, Goldsmith MA, Laine L, Bhatt DL, Investigators C. Efficacy and Safety of Proton-Pump Inhibitors in High-Risk Cardiovascular Subsets of the COGENT Trial. The American Journal Of Medicine 2016, 129: 1002-1005. PMID: 27143321, DOI: 10.1016/j.amjmed.2016.03.042.Peer-Reviewed Original ResearchConceptsDual antiplatelet therapyProton pump inhibitorsAcute coronary syndromePercutaneous coronary interventionCardiovascular eventsCoronary syndromeCoronary interventionGastrointestinal eventsPercutaneous coronary intervention-treated patientsSafety of PPIsUnadjusted Cox proportional hazards modelCox proportional hazards modelDays of randomizationMajor cardiovascular eventsComposite cardiovascular eventsSubset of patientsSafety of omeprazoleProportional hazards modelGastroprotective strategiesMedian followPPI therapyAntiplatelet therapyFrequent indicationHazards modelPatients
2014
Lower Yield of Endoscopic Ultrasound-Guided Fine-Needle Aspiration in Patients with Pancreatic Head Mass with a Biliary Stent
Kim JJ, Walia S, Lee SH, Patel B, Vetsa M, Zhao Y, Srikureja W, Laine L. Lower Yield of Endoscopic Ultrasound-Guided Fine-Needle Aspiration in Patients with Pancreatic Head Mass with a Biliary Stent. Digestive Diseases And Sciences 2014, 60: 543-549. PMID: 25245115, DOI: 10.1007/s10620-014-3367-0.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAgedCholangiopancreatography, Endoscopic RetrogradeEndoscopic Ultrasound-Guided Fine Needle AspirationFemaleHumansJaundice, ObstructiveMaleMiddle AgedMultivariate AnalysisOdds RatioPalliative CarePancreatic NeoplasmsPredictive Value of TestsRetrospective StudiesRisk FactorsStentsTime FactorsTreatment OutcomeConceptsEndoscopic ultrasound-guided fine-needle aspirationEndoscopic retrograde cholangiopancreatographyBiliary stentsFine-needle aspirationJaundiced patientsPancreatic cancerFinal diagnosisHistologic diagnosisPancreatic massOnsite cytopathologistUltrasound-guided fine-needle aspirationPancreatic head massHistologic accuracyResultsMean ageMethodsConsecutive patientsPrimary endpointRadiologic evaluationRetrograde cholangiopancreatographyCore biopsyEndoscopic ultrasoundPatientsMultivariate analysisStentsMalignancyDiagnosis
2012
4-Liter Split-Dose Polyethylene Glycol Is Superior to Other Bowel Preparations, Based on Systematic Review and Meta-analysis
Enestvedt BK, Tofani C, Laine LA, Tierney A, Fennerty MB. 4-Liter Split-Dose Polyethylene Glycol Is Superior to Other Bowel Preparations, Based on Systematic Review and Meta-analysis. Clinical Gastroenterology And Hepatology 2012, 10: 1225-1231. PMID: 22940741, DOI: 10.1016/j.cgh.2012.08.029.Peer-Reviewed Original ResearchConceptsSplit-dose PEGBowel preparation methodsBowel preparation qualityAdjunct therapyRandomized trialsBowel cleansingBowel preparationOdds ratioPooled estimatesSplit dosePublication biasPreparation qualityDose polyethylene glycolSplit-dose regimensCochrane Central RegisterMajor conference proceedingsSignificant heterogeneitySignificant publication biasLow-volume regimensRandom-effects modelSame preparationAbdominal crampingCentral RegisterPatient demographicsControlled TrialsBalloon‐occluded retrograde transvenous obliteration for the treatment of gastric varices
Dadabhai AS, Fenkel JM, Brown DB, Laine L. Balloon‐occluded retrograde transvenous obliteration for the treatment of gastric varices. Hepatology 2012, 55: 1301-1304. PMID: 22318957, DOI: 10.1002/hep.25635.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2011
Double-Blind Randomized Trials of Single-Tablet Ibuprofen/High-Dose Famotidine vs. Ibuprofen Alone for Reduction of Gastric and Duodenal Ulcers
Laine L, Kivitz AJ, Bello AE, Grahn AY, Schiff MH, Taha AS. Double-Blind Randomized Trials of Single-Tablet Ibuprofen/High-Dose Famotidine vs. Ibuprofen Alone for Reduction of Gastric and Duodenal Ulcers. The American Journal Of Gastroenterology 2011, 107: ajg2011443. PMID: 22186979, PMCID: PMC3321505, DOI: 10.1038/ajg.2011.443.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdultAgedAged, 80 and overAnti-Inflammatory Agents, Non-SteroidalAnti-Ulcer AgentsChi-Square DistributionDouble-Blind MethodDrug CombinationsDuodenal UlcerEndoscopy, GastrointestinalFamotidineFemaleHumansIbuprofenMaleMiddle AgedProportional Hazards ModelsRisk FactorsStomach UlcerTreatment OutcomeConceptsPrimary end point analysisNon-steroidal anti-inflammatory drugsUpper GI ulcersDuodenal ulcerGI ulcersGastric ulcerEnd-point analysisDaily non-steroidal anti-inflammatory drugsH. pylori stool testDouble-blind randomized trialsMultiple potential risk factorsReduction of gastricSingle-tablet combinationUpper gastrointestinal ulcersDouble-blind trialProportional hazards analysisPotential risk factorsAnti-inflammatory drugsBaseline endoscopyREDUCE studyStudy endoscopyTablets thriceUlcer complicationsStool testRandomized trialsEvaluation of NT-proBNP and high sensitivity C-reactive protein for predicting cardiovascular risk in patients with arthritis taking longterm nonsteroidal antiinflammatory drugs.
Ruff CT, Morrow DA, Jarolim P, Ren F, Contant CF, Kaur A, Curtis SP, Laine L, Cannon CP, Brune K. Evaluation of NT-proBNP and high sensitivity C-reactive protein for predicting cardiovascular risk in patients with arthritis taking longterm nonsteroidal antiinflammatory drugs. The Journal Of Rheumatology 2011, 38: 1071-8. PMID: 21459935, DOI: 10.3899/jrheum.100880.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnti-Inflammatory Agents, Non-SteroidalArthritis, RheumatoidBiomarkersC-Reactive ProteinCardiovascular DiseasesDiclofenacEtoricoxibFemaleHeart FailureHumansLongitudinal StudiesMaleMiddle AgedMyocardial InfarctionNatriuretic Peptide, BrainOsteoarthritisPeptide FragmentsProspective StudiesPyridinesRetrospective StudiesRisk FactorsSulfonesThrombosisTreatment OutcomeConceptsHigh-sensitivity C-reactive proteinNonsteroidal antiinflammatory drugsSensitivity C-reactive proteinNT-proBNPC-reactive proteinHeart failureCV eventsCV outcomesCV riskThrombotic eventsMyocardial infarctionAntiinflammatory drugsBiomarkers N-terminal pro-B-type natriuretic peptideCardiac biomarkers N-terminal pro-B-type natriuretic peptideN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideChronic nonsteroidal antiinflammatory drugsBaseline NT-proBNPChronic NSAID treatmentLow CV riskNT-proBNP levelsFuture cardiovascular eventsBody mass indexIdentification of patientsTypes of arthritisProton Pump Inhibitor Co-therapy With Clopidogrel: Is There GI Benefit or Cardiovascular Harm?
Laine L. Proton Pump Inhibitor Co-therapy With Clopidogrel: Is There GI Benefit or Cardiovascular Harm? Gastroenterology 2011, 140: 769-772.e2. PMID: 21266209, DOI: 10.1053/j.gastro.2011.01.024.Commentaries, Editorials and Letters
2010
Randomised clinical trial: a novel rabeprazole extended release 50 mg formulation vs. esomeprazole 40 mg in healing of moderate‐to‐severe erosive oesophagitis – the results of two double‐blind studies
Laine L, Katz PO, Johnson DA, Ibegbu I, Goldstein MJ, Chou C, Rossiter G, Lu Y. Randomised clinical trial: a novel rabeprazole extended release 50 mg formulation vs. esomeprazole 40 mg in healing of moderate‐to‐severe erosive oesophagitis – the results of two double‐blind studies. Alimentary Pharmacology & Therapeutics 2010, 33: 203-212. PMID: 21114792, DOI: 10.1111/j.1365-2036.2010.04516.x.Peer-Reviewed Original ResearchConceptsHeartburn resolutionErosive oesophagitisExtended releaseLA grade CSevere erosive oesophagitisDouble-blind trialDouble-blind studyPossibility of benefitCurrent PPIsD oesophagitisSevere oesophagitisGERD patientsSecondary endpointsPrimary endpointSymptomatic resolutionAcid suppressionSubgroup analysisDrug exposureClinical trialsOesophagitisGrade DGrade CFurther evaluationEsomeprazoleAcid inhibition