2021
Acute gastrointestinal bleeding: proposed study outcomes for new randomised controlled trials
Jensen DM, Barkun A, Cave D, Gralnek IM, Jutabha R, Laine L, Lau JYW, Saltzman JR, Soetikno R, Sung JJY. Acute gastrointestinal bleeding: proposed study outcomes for new randomised controlled trials. Alimentary Pharmacology & Therapeutics 2021, 54: 616-626. PMID: 34288017, PMCID: PMC9385213, DOI: 10.1111/apt.16483.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAcute gastrointestinal bleedingGastrointestinal bleedingPrimary endpointRed blood cell transfusionRelevant outcomesHealth care resource utilisationLength of hospitalisationSerious adverse eventsTrial of patientsBlood cell transfusionPeer-reviewed fundingMeaningful primary endpointCell transfusionAcute bleedingAdverse eventsComposite outcomeSecondary outcomesFuture RCTsNew RCTsPrimary outcomeHemostatic outcomesClinical trialsCommon causeOutcome measuresGI source
2014
Intermittent vs Continuous Proton Pump Inhibitor Therapy for High-Risk Bleeding Ulcers: A Systematic Review and Meta-analysis
Sachar H, Vaidya K, Laine L. Intermittent vs Continuous Proton Pump Inhibitor Therapy for High-Risk Bleeding Ulcers: A Systematic Review and Meta-analysis. JAMA Internal Medicine 2014, 174: 1755-1762. PMID: 25201154, PMCID: PMC4415726, DOI: 10.1001/jamainternmed.2014.4056.Peer-Reviewed Original ResearchConceptsHigh-risk bleeding ulcersProton pump inhibitorsAbsolute risk differencePPI therapyBleeding ulcersContinuous infusionRisk differenceRisk ratioSystematic reviewDuplicate independent data extractionUrgent interventionRed blood cell transfusionGuideline-recommended regimenReduction of ulcerBlood cell transfusionCochrane Central RegisterControlled Trials databasesTrial of patientsData extractionIndependent data extractionIntravenous bolus doseRandom-effects modelFixed-effects modelPPI dosePPI infusion