2019
The Shock Index is not accurate at predicting outcomes in patients with upper gastrointestinal bleeding
Saffouri E, Blackwell C, Laursen SB, Laine L, Dalton HR, Ngu J, Shultz M, Norton R, Stanley AJ. The Shock Index is not accurate at predicting outcomes in patients with upper gastrointestinal bleeding. Alimentary Pharmacology & Therapeutics 2019, 51: 253-260. PMID: 31642558, DOI: 10.1111/apt.15541.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overArea Under CurveBlood TransfusionCohort StudiesEndoscopy, GastrointestinalFemaleGastrointestinal HemorrhageHospitalizationHumansMaleMiddle AgedMortalityPredictive Value of TestsPrognosisProspective StudiesReproducibility of ResultsRisk AssessmentSeverity of Illness IndexShockSurvival AnalysisUpper Gastrointestinal TractYoung AdultConceptsUpper gastrointestinal bleedingGlasgow-Blatchford scoreShock indexGastrointestinal bleedingABC scoreMajor transfusionAcute upper gastrointestinal bleedingUK National Confidential EnquiryAdmission Rockall scoreSevere gastrointestinal bleedingMajor clinical endpointsPredictors of outcomeNational Confidential EnquiryRockall scoreBlatchford scoreEndoscopic therapyConsecutive patientsHospital admissionConfidential EnquiryProspective studyClinical endpointsPatient outcomesRisk scoreDeath reportsBleeding
2018
Severity and Outcomes of Upper Gastrointestinal Bleeding With Bloody Vs. Coffee-Grounds Hematemesis
Laine L, Laursen SB, Zakko L, Dalton HR, Ngu JH, Schultz M, Stanley AJ. Severity and Outcomes of Upper Gastrointestinal Bleeding With Bloody Vs. Coffee-Grounds Hematemesis. The American Journal Of Gastroenterology 2018, 113: 358. PMID: 29380820, DOI: 10.1038/ajg.2018.5.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlood PreservationBlood TransfusionEsophageal and Gastric VaricesFemaleGastrointestinal HemorrhageHeart RateHematemesisHemoglobinsHemostasis, EndoscopicHumansMaleMelenaMiddle AgedMortalityProspective StudiesRecurrenceRisk AssessmentSeverity of Illness IndexUpper Gastrointestinal TractConceptsCoffee ground emesisBloody emesisHemostatic interventionUpper gastrointestinal bleedingComposite end pointRisk stratification scoresSystolic blood pressureTiming of endoscopyPredictors of outcomeBeats/minGastrointestinal bleedingConsecutive patientsPrimary outcomeSevere bleedingStratification scoresBlood pressureProspective studyHematemesisMelenaEmesisHigh mortalityEnd pointMortalityOutcomesSeverity
2017
Relationship of time to presentation after onset of upper GI bleeding with patient characteristics and outcomes: a prospective study
Laine L, Laursen SB, Dalton HR, Ngu JH, Schultz M, Stanley AJ. Relationship of time to presentation after onset of upper GI bleeding with patient characteristics and outcomes: a prospective study. Gastrointestinal Endoscopy 2017, 86: 1028-1037. PMID: 28396275, DOI: 10.1016/j.gie.2017.03.1549.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlood TransfusionConfusionDuodenal DiseasesEsophageal DiseasesFemaleGlasgow Coma ScaleHematemesisHemoglobinsHemostasis, EndoscopicHumansLength of StayLethargyMaleMelenaMiddle AgedPatient Acceptance of Health CarePrognosisProspective StudiesSerum AlbuminStomach DiseasesStuporTime-to-TreatmentConceptsUpper GI bleedingPatient characteristicsHemoglobin levelsDecreased hemoglobin levelLikelihood of transfusionLower hemoglobin levelsSignificant independent factorsGI bleedingHospital daysConsecutive patientsUpper GIHemostatic interventionPoor outcomeProspective studyEmergency departmentRelationship of timeMental statusIndependent factorsPatientsMulti-national studyLogistic regressionMelenaOutcomesTransfusionHospitalComparison of risk scoring systems for patients presenting with upper gastrointestinal bleeding: international multicentre prospective study
Stanley AJ, Laine L, Dalton HR, Ngu JH, Schultz M, Abazi R, Zakko L, Thornton S, Wilkinson K, Khor CJ, Murray IA, Laursen SB. Comparison of risk scoring systems for patients presenting with upper gastrointestinal bleeding: international multicentre prospective study. The BMJ 2017, 356: i6432. PMID: 28053181, PMCID: PMC5217768, DOI: 10.1136/bmj.i6432.Peer-Reviewed Original ResearchConceptsUpper gastrointestinal bleedingRockall scoreGastrointestinal bleedingInternational multicentre prospective studyAdmission Rockall scoreFull Rockall scoreGlasgow-Blatchford scoreHigh-risk patientsMulticentre prospective studyAssessment of patientsPNED scoreHospital stayBlatchford scoreDay mortalityConsecutive patientsRisk patientsComposite endpointEndoscopic treatmentProspective studyClinical endpointsClinical utilityLower riskPatientsLarge hospitalsBleeding
2016
High-quality Bowel Preparation Is Required for Detection of Sessile Serrated Polyps
Clark BT, Laine L. High-quality Bowel Preparation Is Required for Detection of Sessile Serrated Polyps. Clinical Gastroenterology And Hepatology 2016, 14: 1155-1162. PMID: 27060426, PMCID: PMC4955697, DOI: 10.1016/j.cgh.2016.03.044.Peer-Reviewed Original ResearchConceptsSessile serrated adenomas/polypsBowel preparation qualityProportion of patientsDetection of adenomasPreparation qualityRight colonBBPS scoresHigh-quality bowel preparationBoston Bowel Preparation ScaleMultivariate logistic regressionBowel Preparation ScaleSerrated adenomas/polypsSessile serrated polypsAdenomas/polypsSurveillance colonoscopyBowel preparationProspective studyAronchick scaleEntire colonSmall proportionSerrated polypsPatientsPreparation ScaleScoring systemAbstractTextYield of repeat forward-view examination of the right side of the colon in screening and surveillance colonoscopy
Clark BT, Parikh ND, Laine L. Yield of repeat forward-view examination of the right side of the colon in screening and surveillance colonoscopy. Gastrointestinal Endoscopy 2016, 84: 126-132. PMID: 26769408, PMCID: PMC4912931, DOI: 10.1016/j.gie.2015.12.030.Peer-Reviewed Original ResearchConceptsAdenoma detection rateForward-view examinationOverall adenoma detection rateSecond examinationRight sideSurveillance colonoscopyAdditional adenomasWest Haven Veterans Affairs Medical CenterVeterans Affairs Medical CenterBoston Bowel Preparation Scale scoreDistal colon cancerNumber of patientsYears of ageDevelopment of cancerSecondary outcomesPrimary outcomeMen 50Prospective studySurveillance intervalsAdenoma detectionDetection rateMedical CenterInitial examinationPatientsColon cancer
2015
Treatment of Refractory Gastrointestinal Strictures With Mitomycin C
Rustagi T, Aslanian HR, Laine L. Treatment of Refractory Gastrointestinal Strictures With Mitomycin C. Journal Of Clinical Gastroenterology 2015, 49: 837-847. PMID: 25626632, DOI: 10.1097/mcg.0000000000000295.Peer-Reviewed Original ResearchConceptsMitomycin C applicationMitomycin CGastrointestinal stricturesSystematic reviewLimited therapeutic interventionsAdditional randomized trialsLarge prospective studiesDifficult management problemSearch of MEDLINEBenign gastrointestinal stricturesTitles/abstractsCutaneous sclerosisAdverse eventsPartial responseComplete responseCaustic injuryRandomized trialsRefractory stricturesEsophageal strictureProspective studyEmbase databasesCommon siteEffective therapyInclusion criteriaOptimal dose
2010
Risk factors for NSAID‐associated upper GI clinical events in a long‐term prospective study of 34 701 arthritis patients
Laine L, Curtis SP, Cryer B, Kaur A, Cannon CP. Risk factors for NSAID‐associated upper GI clinical events in a long‐term prospective study of 34 701 arthritis patients. Alimentary Pharmacology & Therapeutics 2010, 32: 1240-1248. PMID: 20955443, DOI: 10.1111/j.1365-2036.2010.04465.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnti-Inflammatory Agents, Non-SteroidalArthritisCyclooxygenase 2 InhibitorsDiclofenacEtoricoxibFemaleGastrointestinal DiseasesHumansMaleMiddle AgedProportional Hazards ModelsProspective StudiesPyridinesRisk FactorsSulfonesTime FactorsUpper Gastrointestinal TractConceptsClinical eventsRisk factorsLow-dose aspirin useDouble-blind randomized trialsLong-term prospective studiesCox proportional hazards modelNonsteroidal anti-inflammatory drugsDiscontinuation of NSAIDsPredictors of discontinuationUpper GI eventsLow-dose aspirinPotential risk factorsProportional hazards modelAnti-inflammatory drugsAspirin useGI eventsPatient characteristicsArthritis patientsTreat analysisRandomized trialsRheumatoid arthritisProspective studyGI effectsDyspepsiaHazards model
2008
Systematic Review of the Predictors of Recurrent Hemorrhage After Endoscopic Hemostatic Therapy for Bleeding Peptic Ulcers
Elmunzer BJ, Young SD, Inadomi JM, Schoenfeld P, Laine L. Systematic Review of the Predictors of Recurrent Hemorrhage After Endoscopic Hemostatic Therapy for Bleeding Peptic Ulcers. The American Journal Of Gastroenterology 2008, 103: ajg2008521. PMID: 18684171, DOI: 10.1111/j.1572-0241.2008.02070.x.Peer-Reviewed Original ResearchConceptsEndoscopic therapyIndependent predictorsRecurrent hemorrhageProspective studySystematic reviewIntensive care unit observationLarge ulcer sizePosterior duodenal ulcerSecond-look endoscopyEndoscopic hemostatic therapySignificant independent predictorsPrespecified inclusion criteriaComorbid illnessesHemodynamic instabilityHemostatic therapyDuodenal ulcerEndoscopic predictorsPrimary outcomeUlcer sizeMultivariable analysisPooled ratePeptic ulcerClinical managementBibliographic database searchInclusion criteria
2005
The effect of GI bleeding on Helicobacter pylori diagnostic testing: a prospective study at the time of bleeding and 1 month later
Laine LA, Nathwani RA, Naritoku W. The effect of GI bleeding on Helicobacter pylori diagnostic testing: a prospective study at the time of bleeding and 1 month later. Gastrointestinal Endoscopy 2005, 62: 853-859. PMID: 16301025, DOI: 10.1016/j.gie.2005.09.019.Peer-Reviewed Original ResearchConceptsH pylori densityAcute GI bleedingInflammatory cell infiltrationH pyloriGI bleedingHistologic examinationCohort studyCell infiltrationDiagnostic testingBlinded histologic examinationH pylori testingAcute variceal bleedingProspective cohort studyUrban county hospitalProton pump inhibitorsTime of bleedingRapid urease testingVariceal bleedingCase seriesEndoscopic biopsyProspective studyPump inhibitorsBiopsy specimensUrease testingCounty HospitalClinical Utility of Diagnostic Tests for Constipation in Adults: A Systematic Review
Rao S, Ozturk R, Laine L. Clinical Utility of Diagnostic Tests for Constipation in Adults: A Systematic Review. The American Journal Of Gastroenterology 2005, 100: ajg2005283. PMID: 15984989, DOI: 10.1111/j.1572-0241.2005.41845.x.Peer-Reviewed Original ResearchConceptsBlood testsDiagnostic testsSystematic reviewAnorectal manometry studyDiagnosis of constipationRetrospective endoscopic studySlow transit constipationAbdominal X-rayBalloon expulsion testColonic transit studyTransit constipationAnorectal manometryColonic transitEndoscopic studyBalloon expulsionBarium enemaProspective studyExpulsion testPhysiologic abnormalitiesHistorical controlsConstipationManometry studiesStudy populationAlarm featuresMethodological quality
2002
Helicobacter pylori eradication does not worsen quality of life related to reflux symptoms: a prospective trial
Laine L, Dhir V. Helicobacter pylori eradication does not worsen quality of life related to reflux symptoms: a prospective trial. Alimentary Pharmacology & Therapeutics 2002, 16: 1143-1148. PMID: 12030957, DOI: 10.1046/j.1365-2036.2002.01267.x.Peer-Reviewed Original ResearchMeSH Keywords2-PyridinylmethylsulfinylbenzimidazolesAdultAmoxicillinAnti-Bacterial AgentsAnti-Ulcer AgentsBreath TestsClarithromycinDrug Therapy, CombinationDyspepsiaFemaleGastroesophageal RefluxHelicobacter InfectionsHumansLansoprazoleMaleMiddle AgedOmeprazolePenicillinsProspective StudiesQuality of LifeUreaConceptsGastro-oesophageal reflux diseaseQuality of lifeH. pylori therapyPylori therapyReflux diseaseH. pyloriSymptomatic gastro-oesophageal reflux diseaseHelicobacter pylori eradicationHelicobacter pylori therapyPopulation of patientsEnd of therapyUrea breath testReflux symptomsPylori eradicationTriple therapyProspective trialEndoscopic biopsyPrimary complaintProspective studyLife QuestionnaireBreath testPatientsTherapyMonthsSymptoms
1996
A prospective outcome study of patients with clot in an ulcer and the effect of irrigation
Laine L, Stein C, Sharma V. A prospective outcome study of patients with clot in an ulcer and the effect of irrigation. Gastrointestinal Endoscopy 1996, 43: 107-110. PMID: 8635701, DOI: 10.1016/s0016-5107(06)80109-4.Peer-Reviewed Original ResearchConceptsUpper gastrointestinal bleedingEndoscopic therapyVisible vesselActive bleedingFurther bleedingGastrointestinal bleedingHemostatic therapyAdherent clotHigh-risk stigmataLow-risk findingsProspective outcome studyObservation of patientsInitial endoscopyEndoscopic findingsProspective studyExcellent outcomesUlcer baseBleedingClean baseOutcome studiesVigorous irrigationPatientsAppropriate managementVariable prevalenceTherapy
1995
Randomized, prospective study of bipolar electrocoagulation (BPEC) vs. infrared coagulation (IRC) for bleeding internal hemorrhoids (IH)
Yang R, Ha T, Roque J, Laine L. Randomized, prospective study of bipolar electrocoagulation (BPEC) vs. infrared coagulation (IRC) for bleeding internal hemorrhoids (IH). Gastrointestinal Endoscopy 1995, 41: 387. DOI: 10.1016/s0016-5107(05)80401-8.Peer-Reviewed Original Research
1991
The Causes of Esophageal Symptoms in Human Immunodeficiency Virus Infection: A Prospective Study of 110 Patients
Bonacini M, Young T, Laine L. The Causes of Esophageal Symptoms in Human Immunodeficiency Virus Infection: A Prospective Study of 110 Patients. JAMA Internal Medicine 1991, 151: 1567-1572. DOI: 10.1001/archinte.1991.00400080067012.Peer-Reviewed Original ResearchHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionBlind brushingHerpes simplex virusViral cultureHistologic examinationVirus infectionCandida esophagitisEsophageal symptomsSimplex virusViral infectionPositive predictive valueDiagnosis of esophagitisEsophageal infectionsInfectious esophagitisViral esophagitisConsecutive patientsOral thrushOrogastric tubeEsophageal biopsiesProspective studyVirologic testingBiopsy specimensEsophageal brushingsEsophagitisThe causes of esophageal symptoms in human immunodeficiency virus infection. A prospective study of 110 patients.
Bonacini M, Young T, Laine L. The causes of esophageal symptoms in human immunodeficiency virus infection. A prospective study of 110 patients. JAMA Internal Medicine 1991, 151: 1567-72. PMID: 1651690, DOI: 10.1001/archinte.151.8.1567.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionBlind brushingHerpes simplex virusViral cultureHistologic examinationVirus infectionCandida esophagitisEsophageal symptomsSimplex virusViral infectionProspective clinical case studyUrban county hospitalPositive predictive valueDiagnosis of esophagitisEsophageal infectionsInfectious esophagitisViral esophagitisConsecutive patientsOral thrushOrogastric tubeEsophageal biopsiesProspective studyVirologic testingBiopsy specimens