2017
Relationship of time to presentation after onset of upper GI bleeding with patient characteristics and outcomes: a prospective study
Laine L, Laursen SB, Dalton HR, Ngu JH, Schultz M, Stanley AJ. Relationship of time to presentation after onset of upper GI bleeding with patient characteristics and outcomes: a prospective study. Gastrointestinal Endoscopy 2017, 86: 1028-1037. PMID: 28396275, DOI: 10.1016/j.gie.2017.03.1549.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlood TransfusionConfusionDuodenal DiseasesEsophageal DiseasesFemaleGlasgow Coma ScaleHematemesisHemoglobinsHemostasis, EndoscopicHumansLength of StayLethargyMaleMelenaMiddle AgedPatient Acceptance of Health CarePrognosisProspective StudiesSerum AlbuminStomach DiseasesStuporTime-to-TreatmentConceptsUpper GI bleedingPatient characteristicsHemoglobin levelsDecreased hemoglobin levelLikelihood of transfusionLower hemoglobin levelsSignificant independent factorsGI bleedingHospital daysConsecutive patientsUpper GIHemostatic interventionPoor outcomeProspective studyEmergency departmentRelationship of timeMental statusIndependent factorsPatientsMulti-national studyLogistic regressionMelenaOutcomesTransfusionHospital
2016
No Benefit From Platelet Transfusion for Gastrointestinal Bleeding in Patients Taking Antiplatelet Agents
Zakko L, Rustagi T, Douglas M, Laine L. No Benefit From Platelet Transfusion for Gastrointestinal Bleeding in Patients Taking Antiplatelet Agents. Clinical Gastroenterology And Hepatology 2016, 15: 46-52. PMID: 27464591, DOI: 10.1016/j.cgh.2016.07.017.Peer-Reviewed Original ResearchConceptsGastrointestinal bleedingAntiplatelet agentsPlatelet transfusionsCardiovascular eventsNon-variceal upper gastrointestinal bleedingYale-New Haven HospitalRecurrent gastrointestinal bleedingSerious gastrointestinal bleedingMajor cardiovascular eventsRetrospective cohort studySevere gastrointestinal bleedingUpper gastrointestinal bleedingLower blood pressureMultivariable regression analysisHigher heart rateLack of benefitRecurrent bleedingBaseline characteristicsCohort studyBlood pressurePrimary outcomeSuch patientsHemoglobin levelsMultivariable analysisIntensive care
2010
Does Capsule Endoscopy Improve Outcomes in Obscure Gastrointestinal Bleeding? Randomized Trial Versus Dedicated Small Bowel Radiography
Laine L, Sahota A, Shah A. Does Capsule Endoscopy Improve Outcomes in Obscure Gastrointestinal Bleeding? Randomized Trial Versus Dedicated Small Bowel Radiography. Gastroenterology 2010, 138: 1673-1680.e1. PMID: 20138043, DOI: 10.1053/j.gastro.2010.01.047.Peer-Reviewed Original ResearchConceptsObscure GI bleedingObscure gastrointestinal bleedingDiagnostic yieldGI bleedingGastrointestinal bleedingTherapeutic interventionsCapsule endoscopyNegative upper endoscopySubsequent blood transfusionSmall bowel radiographyOccult bleedingPrimary endpointSubsequent hospitalizationMost patientsUpper endoscopyBlood transfusionHemoglobin levelsRandomized trialsVs 5Improved outcomesBleedingContrast radiographyPatientsEndoscopyAbstractText