2022
Patterns of cardiometabolic multimorbidity and the risk of depressive symptoms in a longitudinal cohort of middle-aged and older Chinese
Huang ZT, Luo Y, Han L, Wang K, Yao SS, Su HX, Chen S, Cao GY, De Fries CM, Chen ZS, Xu HW, Hu YH, Xu B. Patterns of cardiometabolic multimorbidity and the risk of depressive symptoms in a longitudinal cohort of middle-aged and older Chinese. Journal Of Affective Disorders 2022, 301: 1-7. PMID: 34999125, DOI: 10.1016/j.jad.2022.01.030.Peer-Reviewed Original ResearchConceptsCardiometabolic multimorbidityCardiometabolic diseasesHeart diseaseDepressive symptomsSelf-reported chronic conditionsEpidemiological Studies Depression ScaleAbsence of strokeRisk of depressionRetirement Longitudinal Study 2011Multiple cardiometabolic diseasesDose effectMental health preventionOlder ChineseAdditive effectChronic conditionsDisease combinationsLongitudinal cohortDepression ScaleHigh riskMultimorbidityPerson-centered healthcareDiabetesSymptomsHealth preventionChina Health
2020
Associations Between Somatic Multimorbidity Patterns and Depression in a Longitudinal Cohort of Middle-Aged and Older Chinese
Yao SS, Cao GY, Han L, Huang ZT, Chen ZS, Su HX, Hu Y, Xu B. Associations Between Somatic Multimorbidity Patterns and Depression in a Longitudinal Cohort of Middle-Aged and Older Chinese. Journal Of The American Medical Directors Association 2020, 21: 1282-1287.e2. PMID: 31928934, DOI: 10.1016/j.jamda.2019.11.028.Peer-Reviewed Original ResearchConceptsChronic somatic conditionsSomatic multimorbidityDepressive symptomsOlder Chinese adultsSomatic conditionsChinese adultsEpidemiological Studies Depression ScaleLongitudinal associationsRetirement Longitudinal Study 2011Multimorbidity patternsLongitudinal cohortDepression ScaleRespiratory conditionsHigh riskGreater oddsRespiratory patternMental disordersSymptomsChina HealthGreater riskOlder populationOlder adultsSkeletal patternClinical practitionersDepression
2019
The Epidemiology of Patient‐Reported Hypersomnia in Persons With Advanced Age
Miner B, Gill TM, Yaggi HK, Redeker NS, Van Ness PH, Han L, Fragoso C. The Epidemiology of Patient‐Reported Hypersomnia in Persons With Advanced Age. Journal Of The American Geriatrics Society 2019, 67: 2545-2552. PMID: 31390046, PMCID: PMC6898735, DOI: 10.1111/jgs.16107.Peer-Reviewed Original ResearchConceptsSelf-reported sleep-disordered breathingRestless legs syndromeMean ESS scoreCommunity-dwelling personsESS scoreCross-sectional associationsAdvanced ageHypersomnia symptomsCentral nervous system depressant medicationsEpworth Sleepiness Scale scoreMini-Mental State Examination scoreEpidemiologic Studies-Depression scoreSelf-reported medical conditionsEpidemiology of patientsLow physical activitySleep-disordered breathingBody mass indexPhysical Activity ScalePrecipitating Events ProjectState Examination scoreInsomnia Severity IndexMultivariable regression modelsDepressant medicationsClinical characteristicsCross-sectional design
2018
Insomnia in Community‐Living Persons with Advanced Age
Miner B, Gill TM, Yaggi HK, Redeker NS, Van Ness PH, Han L, Fragoso CAV. Insomnia in Community‐Living Persons with Advanced Age. Journal Of The American Geriatrics Society 2018, 66: 1592-1597. PMID: 29785710, PMCID: PMC6167156, DOI: 10.1111/jgs.15414.Peer-Reviewed Original ResearchConceptsSelf-reported sleep-disordered breathingRestless legs syndromeInsomnia Severity IndexDepressive symptomsBaseline characteristicsOlder adultsCognitive impairmentAverage baseline characteristicsEpidemiology of insomniaChronic lung diseaseSleep-disordered breathingMultivariable regression modelsHigh medical burdenCurrent smokersLegs syndromeLung diseaseClinical correlatesDaytime sleepinessSleep disturbancesAdvanced ageMedical burdenMild severityCardiovascular diseaseDiagnostic confirmationHigh prevalence
2013
Risk Factors for Restricting Back Pain in Older Persons
Makris UE, Fraenkel L, Han L, Leo-Summers L, Gill TM. Risk Factors for Restricting Back Pain in Older Persons. Journal Of The American Medical Directors Association 2013, 15: 62-67. PMID: 24239445, PMCID: PMC3872215, DOI: 10.1016/j.jamda.2013.09.013.Peer-Reviewed Original ResearchConceptsPersistent/recurrentCandidate risk factorsRisk factorsBack painOlder personsFemale sexComprehensive home-based assessmentsMultivariable Cox modelProspective cohort studyMonthly telephone interviewsMore chronic conditionsWeak grip strengthHome-based assessmentHip weaknessCohort studyCumulative incidenceIncident episodesMultivariable analysisProspective studyGrip strengthChronic conditionsPainCox modelDepressive symptomsRestricted activity
2011
Antidepressant Use and Cognitive Deficits in Older Men: Addressing Confounding by Indications with Different Methods
Han L, Kim N, Brandt C, Allore HG. Antidepressant Use and Cognitive Deficits in Older Men: Addressing Confounding by Indications with Different Methods. Annals Of Epidemiology 2011, 22: 9-16. PMID: 22037381, PMCID: PMC4054866, DOI: 10.1016/j.annepidem.2011.10.004.Peer-Reviewed Original ResearchConceptsDepression-related diagnosisAntidepressant useDepression symptomsOlder personsPropensity scoreHopkins Verbal Learning TestHypertensive menAntidepressant medicationIndication biasVerbal Learning TestMedical recordsPotential confoundingCumulative exposureOlder menCognitive impairmentMemory deficitsCognitive deficitsMultiple linear regressionLinear regressionLearning TestApparent associationScoresSymptomsDiagnosisIndications
2007
Association Between Antihypertensive Medication Use and Non-cardiovascular Outcomes in Older Men
Agostini JV, Tinetti ME, Han L, Peduzzi P, Foody JM, Concato J. Association Between Antihypertensive Medication Use and Non-cardiovascular Outcomes in Older Men. Journal Of General Internal Medicine 2007, 22: 1661-1667. PMID: 17899299, PMCID: PMC2219823, DOI: 10.1007/s11606-007-0388-9.Peer-Reviewed Original ResearchConceptsNon-cardiovascular outcomesAntihypertensive medication useAntihypertensive medicationsMedication useAdverse effectsOlder menCommunity-living older menVeterans Affairs primary care clinicsEpidemiologic Studies-Depression scoreOlder adultsMultiple antihypertensive medicationsPhysical performancePrimary care clinicsDrug adverse effectsRoutine clinical practiceCES-D scoresHigh cumulative exposureRelated adverse effectsTrail Making BMedication intensityTest Part BHypertensive menCerebrovascular effectsCohort studyBlood pressureEffects of Statin Use on Muscle Strength, Cognition, and Depressive Symptoms in Older Adults
Agostini JV, Tinetti ME, Han L, McAvay G, Foody JM, Concato J. Effects of Statin Use on Muscle Strength, Cognition, and Depressive Symptoms in Older Adults. Journal Of The American Geriatrics Society 2007, 55: 420-425. PMID: 17341246, DOI: 10.1111/j.1532-5415.2007.01071.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCognitionCohort StudiesComorbidityConnecticutDepressionDrug Therapy, CombinationDrug UtilizationFemaleGeriatric AssessmentHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLongitudinal StudiesMaleMuscle StrengthNeuropsychological TestsPrimary Health CareProspective StudiesRisk AssessmentVeteransConceptsStatin usersMuscle strengthTest Part BStatin useDepression scoresEpidemiologic Studies Depression Scale scoreOutpatient primary care clinicsOlder adultsConcomitant medication useProximal muscle strengthObservational cohort studyPeripheral vascular diseasePrimary care clinicsDepression Scale scoresHigh-risk participantsHydroxymethyl glutaryl coenzymeCommunity-dwelling veteransCommunity-dwelling male participantsGreater comorbidityStatin therapyCohort studyMedian durationStatin prescriptionMedication useCare clinics
2006
The Temporal Relationship Between Depression Symptoms and Cognitive Functioning in Older Medical Patients—Prospective or Concurrent?
Han L, McCusker J, Abrahamowicz M, Cole M, Capek R. The Temporal Relationship Between Depression Symptoms and Cognitive Functioning in Older Medical Patients—Prospective or Concurrent? The Journals Of Gerontology Series A 2006, 61: 1319-1323. PMID: 17234828, DOI: 10.1093/gerona/61.12.1319.Peer-Reviewed Original ResearchMeSH KeywordsAgedCognitionCognition DisordersDepressionFemaleFollow-Up StudiesHumansMaleTime FactorsConceptsMini-Mental State ExaminationHamilton Depression Rating ScaleHDRS scoresDepression symptomsCognitive impairmentInpatients 65 yearsIndependent risk factorTime pointsOlder medical patientsDepression Rating ScaleOld-age depressionLower MMSE scoresSame time pointsCognitive functioningSubsequent time pointsOne-point increaseTemporal relationshipCardiovascular riskMMSE changeIllness severityMedical patientsRisk factorsMMSE scoresDepressive symptomsEpidemiological studies