Featured Publications
Use of Medications With Anticholinergic Effect Predicts Clinical Severity of Delirium Symptoms in Older Medical Inpatients
Han L, McCusker J, Cole M, Abrahamowicz M, Primeau F, Elie M. Use of Medications With Anticholinergic Effect Predicts Clinical Severity of Delirium Symptoms in Older Medical Inpatients. JAMA Internal Medicine 2001, 161: 1099-1105. PMID: 11322844, DOI: 10.1001/archinte.161.8.1099.Peer-Reviewed Original ResearchConceptsDelirium severityACH medicationsMedication exposureDelirium symptomsMedical inpatientsInpatients 65 yearsModifiable risk factorsOlder medical inpatientsUse of medicationsPresence of dementiaElderly medical inpatientsMixed linear regression modelsAnticholinergic medicationsACh effectsAnticholinergic effectsMedication usePrevalent deliriumDelirium IndexRisk factorsClinical severityMedicationsDeliriumSymptom severityLongitudinal associationsSeverity
2020
Guardianship and End‐of‐Life Care for Veterans with Dementia in Nursing Homes
Cohen AB, Han L, OʼLeary JR, Fried TR. Guardianship and End‐of‐Life Care for Veterans with Dementia in Nursing Homes. Journal Of The American Geriatrics Society 2020, 69: 342-348. PMID: 33170957, PMCID: PMC7902349, DOI: 10.1111/jgs.16900.Peer-Reviewed Original ResearchConceptsDays of lifeHospital deathHigh-intensity treatmentMechanical ventilationTube placementHome residentsCardiopulmonary resuscitationNursing homesIntensive care unit admissionMinimum Data Set assessmentsCare unit admissionRetrospective cohort studyNursing home residentsHigh-intensity endMore nursing homesUnit admissionICU admissionCohort studySecondary outcomesPrimary outcomeHospital transferLife hospitalizationsSevere dementiaLife careDementia severityPredictors of Residential Care Admission in Community-Dwelling Older People With Dementia
Jamieson H, Abey-Nesbit R, Nishtala PS, Allore H, Han L, Deely JM, Pickering JW. Predictors of Residential Care Admission in Community-Dwelling Older People With Dementia. Journal Of The American Medical Directors Association 2020, 21: 1665-1670. PMID: 32646821, PMCID: PMC7641960, DOI: 10.1016/j.jamda.2020.04.021.Peer-Reviewed Original ResearchConceptsAged residential careSubdistribution hazard ratiosMultivariable competing-risk modelResidential care admissionAbsence of dementiaDay of assessmentOlder New ZealandersRisk prediction modelPoor cognitive performanceCompeting-risks modelInterRAI-HC assessmentInterRAI dataCare admissionHazard ratioObservational studyReduced riskDaily livingExclusion criteriaHigh riskAlcohol consumptionDementiaOlder peopleResidential careSocial isolationCognitive performance
2018
Diabetes, Heart Disease, and Dementia: National Estimates of Functional Disability Trajectories
Vroomen J, Han L, Monin JK, Lipska KJ, Allore HG. Diabetes, Heart Disease, and Dementia: National Estimates of Functional Disability Trajectories. Journal Of The American Geriatrics Society 2018, 66: 766-772. PMID: 29521414, PMCID: PMC5906138, DOI: 10.1111/jgs.15284.Peer-Reviewed Original ResearchConceptsHeart diseaseDisability trajectoriesPossible dementiaNational estimatesChronic conditionsGreater oddsPhysician-diagnosed chronic conditionsCognitive statusCommunity-dwelling Medicare beneficiariesMultiple chronic conditionsAging Trends StudyComplex survey designGroup-based trajectory modelingADL disabilityNational HealthProbable dementiaDaily livingMultinomial logistic regressionMedicare beneficiariesDiabetesStudy attritionConcurrent conditionsDementiaSociodemographic characteristicsSevere disability
2015
The role of intervening hospital admissions on trajectories of disability in the last year of life: prospective cohort study of older people
Gill TM, Gahbauer EA, Han L, Allore HG. The role of intervening hospital admissions on trajectories of disability in the last year of life: prospective cohort study of older people. The BMJ 2015, 350: h2361. PMID: 25995357, PMCID: PMC4443433, DOI: 10.1136/bmj.h2361.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedCohort StudiesConnecticutDementiaDisability EvaluationDisabled PersonsDisease ProgressionFemaleFrail ElderlyGeriatric AssessmentHospitalizationHumansMaleMultiple Organ FailureNeoplasmsPrognosisProspective StudiesSeverity of Illness IndexTerminal CareUnited StatesConceptsCourse of disabilityProspective cohort studyHospital admissionTrajectories of disabilitySeverity of disabilityCatastrophic disabilitySevere disabilityCohort studyAcute hospital admissionPalliative care approachMultiple hospital admissionsAdvance care planningPersonal care needsEnd of lifeDisability scoresOlder patientsPotential confoundersOccurrence of admissionMultivariable modelCare planningMAIN OUTCOMECare approachDaily livingCare needsAdmission
2006
Recoverable Cognitive Dysfunction at Hospital Admission in Older Persons During Acute Illness
Inouye SK, Zhang Y, Han L, Leo‐Summers L, Jones R, Marcantonio E. Recoverable Cognitive Dysfunction at Hospital Admission in Older Persons During Acute Illness. Journal Of General Internal Medicine 2006, 21: 1276-1281. PMID: 16965558, PMCID: PMC1924736, DOI: 10.1111/j.1525-1497.2006.00613.x.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAcute DiseaseAgedAged, 80 and overCognition DisordersCohort StudiesDeliriumDementiaEducational StatusFemaleHospitalizationHumansIncidenceMalePredictive Value of TestsProspective StudiesPsychiatric Status Rating ScalesRecovery of FunctionSeverity of Illness IndexConceptsMini-Mental State ExaminationCognitive dysfunctionAcute illnessOlder personsProspective cohort studyAdjusted odds ratioHigher illness severityPotential clinical implicationsMajority of casesHigher educational levelCohort studyHospital admissionPrimary outcomeIllness severityMultivariable analysisConsecutive admissionsOdds ratioAcademic hospitalFunctional impairmentMMSE scoresState ExaminationDeliriumMMSE impairmentDysfunctionPatients
2003
The Course of Delirium in Older Medical Inpatients
McCusker J, Cole M, Dendukuri N, Han L, Belzile É. The Course of Delirium in Older Medical Inpatients. Journal Of General Internal Medicine 2003, 18: 696-704. PMID: 12950477, PMCID: PMC1494920, DOI: 10.1046/j.1525-1497.2003.20602.x.Peer-Reviewed Original ResearchConceptsOutcome of deliriumClinical courseMedical inpatientsCourse of deliriumHospital clinical courseProspective cohort studyOlder medical inpatientsTime of diagnosisSeverity of illnessSubgroup of patientsNursing home residencePost-discharge outcomesAcute care hospitalsRole of dementiaHospital courseInitial hospitalizationCohort studyPersistent symptomsCare hospitalHospital recoveryMedical wardsFunctional outcomeAdmission levelsDaily livingDeliriumAn Empirical Study of Different Diagnostic Criteria for Delirium Among Elderly Medical Inpatients
Cole MG, Dendukuri N, McCusker J, Han L. An Empirical Study of Different Diagnostic Criteria for Delirium Among Elderly Medical Inpatients. Journal Of Neuropsychiatry 2003, 15: 200-207. PMID: 12724462, DOI: 10.1176/jnp.15.2.200.Peer-Reviewed Original ResearchAgedAged, 80 and overConfusionDeliriumDementiaDiagnosis, DifferentialDiagnostic and Statistical Manual of Mental DisordersEmpirical ResearchFemaleGeriatric AssessmentHumansInpatientsInternational Classification of DiseasesMaleProspective StudiesPsychiatric Status Rating ScalesRandomized Controlled Trials as TopicReproducibility of ResultsSensitivity and Specificity
2002
Symptoms of Delirium Among Elderly Medical Inpatients With or Without Dementia
Cole MG, McCusker J, Dendukuri N, Han L. Symptoms of Delirium Among Elderly Medical Inpatients With or Without Dementia. Journal Of Neuropsychiatry 2002, 14: 167-175. PMID: 11983791, DOI: 10.1176/jnp.14.2.167.Peer-Reviewed Original Research