Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance
Yu J, Yan Y, Li S, Xu Y, Parolia A, Rizvi S, Wang W, Zhai Y, Xiao R, Li X, Liao P, Zhou J, Okla K, Lin H, Lin X, Grove S, Wei S, Vatan L, Hu J, Szumilo J, Kotarski J, Freeman Z, Skala S, Wicha M, Cho K, Chinnaiyan A, Schon S, Wen F, Kryczek I, Wang S, Chen L, Zou W. Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance. Cell 2024, 187: 4713-4732.e19. PMID: 38968937, PMCID: PMC11344674, DOI: 10.1016/j.cell.2024.06.012.Peer-Reviewed Original ResearchB7-H4Immune toleranceProgesterone receptorCD8<sup>+</sup> T cell exhaustionImmune tolerance checkpointB7-H4 expressionT cell exhaustionImmune tolerance mechanismsMaternal-fetal interfaceBreast cancer modelFemale sex hormonesBreast cancer progressionBreast cancer cellsTolerance checkpointsFetal resorptionHuman cancer typesHormonal screeningImmune activationPregnancy modelCancer modelsSex hormonesCell exhaustionPR antagonistsGenetic deficiencyCancer cells