2021
Circadian Rhythm Modulation of Microbes During Health and Infection
Pearson JA, Voisey AC, Boest-Bjerg K, Wong FS, Wen L. Circadian Rhythm Modulation of Microbes During Health and Infection. Frontiers In Microbiology 2021, 12: 721004. PMID: 34512600, PMCID: PMC8430216, DOI: 10.3389/fmicb.2021.721004.Peer-Reviewed Original ResearchGut bacteriaProtective immune responseBeneficial therapeutic responseCircadian rhythm modulationVaccination responseTherapeutic responseTherapeutic administrationImmune responseTherapeutic successCircadian rhythm effectsHost immunityRhythm modulationAdverse effectsInfectionDay-dependent changesAdministration strategiesAltered susceptibilityRhythm effectsCircadian rhythmHealthCircadian modulationVirusOptimal timePhysiological processesResponse
2020
Crosstalk between circadian rhythms and the microbiota
Pearson JA, Wong FS, Wen L. Crosstalk between circadian rhythms and the microbiota. Immunology 2020, 161: 278-290. PMID: 33090484, PMCID: PMC7692254, DOI: 10.1111/imm.13278.Peer-Reviewed Original ResearchConceptsHost circadian rhythmsMicrobial oscillationsGene/protein expressionAspects of biologyCircadian rhythmMicrobial associationsMolecular oscillationsCircadian oscillationsMicrobial compositionMicrobial influenceCause diseaseMolecular techniquesHost metabolismDisease susceptibilityMicrobial changesProtein expressionPeripheral rhythmsMain inducerMicrobiotaSleep-wake cycleHost immunityCrosstalkClinical successPotential connectionMicrobesAltered Systemic and Intestinal IgA Immune Responses in Individuals With Type 1 Diabetes
Huang J, Huang G, Li X, Hu F, Xie Z, Xiao Y, Luo S, Chao C, Guo K, Wong FS, Zhou Z, Wen L. Altered Systemic and Intestinal IgA Immune Responses in Individuals With Type 1 Diabetes. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa590. PMID: 32860693, PMCID: PMC7549925, DOI: 10.1210/clinem/dgaa590.Peer-Reviewed Original ResearchConceptsIgA-bound bacteriaType 1 diabetesHealthy control individualsIgA immune responseControl individualsIgA immunityAutoantibody titersIgA concentrationsImmune responseType 1 diabetes patientsΒ-cell autoimmunityLonger disease durationSerum IgA concentrationNovel therapeutic targetEnzyme-linked immunosorbentDisease durationIgA levelsDiabetes patientsDiabetes displayGut homeostasisBlood samplesOral cavityTherapeutic targetDiabetesHost immunity