1995
Hyperinsulinemia inhibits myocardial protein degradation in patients with cardiovascular disease and insulin resistance.
McNulty P, Louard R, Deckelbaum L, Zaret B, Young L. Hyperinsulinemia inhibits myocardial protein degradation in patients with cardiovascular disease and insulin resistance. Circulation 1995, 92: 2151-6. PMID: 7554195, DOI: 10.1161/01.cir.92.8.2151.Peer-Reviewed Original ResearchConceptsMyocardial protein degradationInsulin infusionCardiovascular diseaseMyocardial protein synthesisInsulin resistancePhenylalanine balanceMyocardial hypertrophyWhole-body glucose metabolismCoronary artery diseaseIschemic heart diseasePlasma insulin concentrationNet phenylalanine balanceWhole-body carbohydrate metabolismEffect of insulinMyocardial protein metabolismArtery diseaseAcute hyperinsulinemiaProtein synthesisHeart diseaseInsulin concentrationsPlasma concentrationsAntiproteolytic actionHyperinsulinemiaGlucose metabolismConstant infusion
1994
Effect of insulin on rat heart and skeletal muscle phenylalanyl-tRNA labeling and protein synthesis in vivo
Young LH, Stirewalt W, McNulty PH, Revkin JH, Barrett EJ. Effect of insulin on rat heart and skeletal muscle phenylalanyl-tRNA labeling and protein synthesis in vivo. American Journal Of Physiology 1994, 267: e337-e342. PMID: 8074214, DOI: 10.1152/ajpendo.1994.267.2.e337.Peer-Reviewed Original ResearchConceptsMuscle protein synthesisAcid-soluble poolFemoral venous plasmaSkeletal muscleSkeletal muscle protein synthesisEffect of insulinMuscle protein hydrolysateProtein synthesisContinuous infusionVenous plasmaHyperinsulinemic clampSaline infusionAnesthetized ratsArterial plasmaRat heartInsulin effectInsulinHormonal regulationHeartInfusionMuscleSpecific activityMinVivo measurementsLabeling
1988
Effect of Chronic Diabetes on Myocardial Fuel Metabolism and Insulin Sensitivity
Barrett E, Schwartz R, Young L, Jacob R, Zaret B. Effect of Chronic Diabetes on Myocardial Fuel Metabolism and Insulin Sensitivity. Diabetes 1988, 37: 943-948. PMID: 3290011, DOI: 10.2337/diab.37.7.943.Peer-Reviewed Original ResearchConceptsArterial free fatty acidsFree fatty acidsMyocardial balanceInsulin clampBranched-chain amino acid concentrationsEuglycemic insulin clamp techniqueGlucose uptakeInsulin-induced hypoaminoacidemiaInsulin clamp techniqueInsulin-deficient diabetesPlasma glucose concentrationFuel substrate metabolismSignificant myocardial uptakeEffect of insulinMyocardial fuel metabolismSignificant glucose uptakePhysiologic hyperinsulinemiaBasal periodChronic diabetesDiabetic animalsInsulin sensitivityAcute effectsAdditional dogsAmino acid concentrationsMyocardial uptake