2024
Exploring the Impact of Age, Frailty, and Multimorbidity on the Effect of ICU Interventions: A Systematic Review of Randomized Controlled Trials
Perrella A, Geen O, Ahuja M, Scott S, Kaushik R, Ferrante L, Brummel N, Muscedere J, Rochwerg B. Exploring the Impact of Age, Frailty, and Multimorbidity on the Effect of ICU Interventions: A Systematic Review of Randomized Controlled Trials. Critical Care Medicine 2024, 52: e463-e472. PMID: 38661459, DOI: 10.1097/ccm.0000000000006315.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCritical care interventionsRandomized controlled trialsCare interventionsOlder adultsCluster randomized controlled trialStatistically significant effect modificationSubgroup effectsIll older adultsControlled trialsCritically ill older adultsSystematic review of randomized controlled trialsSignificant effect modificationReview of randomized controlled trialsCritical care randomized controlled trialsCritical care journalsStatistically significant subgroup effectsIndividual patient preferencesSubgroups of ageIntervention effectsMultimorbidityEffect modificationFrailty subgroupsICU interventionsStudy characteristicsGeneral medicine
2022
Trends in Geriatric Conditions Among Older Adults Admitted to US ICUs Between 1998 and 2015
Cobert J, Jeon SY, Boscardin J, Chapman AC, Ferrante LE, Lee S, Smith AK. Trends in Geriatric Conditions Among Older Adults Admitted to US ICUs Between 1998 and 2015. CHEST Journal 2022, 161: 1555-1565. PMID: 35026299, PMCID: PMC9248079, DOI: 10.1016/j.chest.2021.12.658.Peer-Reviewed Original ResearchConceptsICU admissionPre-existing disabilityGeriatric conditionsOlder adultsSelf-reported chronic diseasesPatients 65 yearsRate of dementiaICU patientsAdverse outcomesICU settingChronic diseasesAdjusted proportionDaily livingMultimorbidityICUAdmissionGeriatric principlesFrailtyDementiaUS ICUsFunctional measuresStudy designDisabilityAdultsTime trends