2001
A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation
Das J, Chen C, Yang L, Cohn L, Ray P, Ray A. A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation. Nature Immunology 2001, 2: 45-50. PMID: 11135577, DOI: 10.1038/83158.Peer-Reviewed Original ResearchConceptsAllergic airway inflammationT helper 2GATA-3 expressionTh2 differentiationAirway inflammationGATA3 expressionAirway eosinophilic inflammationTh2 cytokine productionT-bet expressionInterferon-γ ProductionTh2 cell recruitmentTranscription factor GATA-3NF-κB activityNuclear factor κBT cell receptorEosinophilic inflammationHelper 2Asthma pathogenesisCytokine productionIL-13IL-5Th2 cellsT cellsInterleukin-4Cell recruitment
1999
Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3
Zhang D, Yang L, Cohn L, Parkyn L, Homer R, Ray P, Ray A. Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3. Immunity 1999, 11: 473-482. PMID: 10549629, DOI: 10.1016/s1074-7613(00)80122-3.Peer-Reviewed Original ResearchMeSH KeywordsAerosolsAmino Acid SubstitutionAnimalsAsthmaBronchoalveolar Lavage FluidDNA-Binding ProteinsDrug HypersensitivityEosinophiliaGATA3 Transcription FactorGene Expression RegulationGenes, DominantImmunizationImmunoglobulin EInflammationInterleukin-13Interleukin-4Interleukin-5LungMiceMice, Inbred C57BLMice, TransgenicMucusMutagenesis, Site-DirectedOvalbuminTh2 CellsTrans-ActivatorsConceptsCytokines IL-4GATA-3IL-13IL-4IL-5Th2 cytokines IL-4Pathogenesis of asthmaTreatment of asthmaTranscription factor GATA-3Potential therapeutic targetAirway eosinophiliaTh2 responsesAllergic inflammationAllergic diseasesTh2 cytokinesT-cell-specific fashionTh1 cellsIgE synthesisTh2 cellsMucus productionMurine modelTherapeutic targetTransgenic miceAsthmaDominant negative mutant
1997
Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene*
Zhang D, Cohn L, Ray P, Bottomly K, Ray A. Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene*. Journal Of Biological Chemistry 1997, 272: 21597-21603. PMID: 9261181, DOI: 10.1074/jbc.272.34.21597.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsClone CellsDNA-Binding ProteinsDown-RegulationGATA3 Transcription FactorGene Expression Regulation, DevelopmentalHeLa CellsHumansInterleukin-5Lymphocyte ActivationMiceNFATC Transcription FactorsNuclear ProteinsPromoter Regions, GeneticRNA, MessengerSpleenTh1 CellsTh2 CellsTrans-ActivatorsTranscription Factor AP-1Transcription FactorsTranscription, GeneticTranscriptional ActivationUp-RegulationConceptsGene expressionPromoter activationTranscription factor GATA-3Th2 cellsTh1 cellsGATA-3 sitesGATA-3 activityInterleukin-5 geneGATA-3GATA-3 proteinIL-5 promoterIL-5 geneTh2-specific expressionEctopic expressionMolecular basisInterleukin-5T cell receptor transgenic miceT helper 2 cellsReceptor transgenic miceTh2-type cytokinesTreatment of asthmaT helper cellsGATA-3 gene expressionDevelopment of eosinophiliaEL-4 cells