2007
A Novel Pathway That Regulates Inflammatory Disease in the Respiratory Tract
Niu N, Le Goff MK, Li F, Rahman M, Homer RJ, Cohn L. A Novel Pathway That Regulates Inflammatory Disease in the Respiratory Tract. The Journal Of Immunology 2007, 178: 3846-3855. PMID: 17339484, DOI: 10.4049/jimmunol.178.6.3846.Peer-Reviewed Original ResearchConceptsAirway inflammationInflammatory diseasesRespiratory tractTh2-induced airway inflammationChronic airway inflammatory diseaseLymphocyte-deficient miceState of immunosuppressionAcute airway inflammationAirway inflammatory diseasesEffector Th cellsTh2 cells resultsAirway hyperresponsivenessInflammation wanesTh2 modelEffector Th1Respiratory illnessTh cellsInhalational exposureInflammationInhibitory effectSuch diseasesDiseaseStriking inhibitionTh1Localized treatment
2000
T-helper type 2 cell-directed therapy for asthma
Cohn L, Ray A. T-helper type 2 cell-directed therapy for asthma. Pharmacology & Therapeutics 2000, 88: 187-196. PMID: 11150597, DOI: 10.1016/s0163-7258(00)00091-7.BooksConceptsTh2 cell differentiationT helper type 2 cellsNew immunomodulatory strategiesCell-directed therapiesChronic inflammatory diseaseTh2 cell functionType 2 cellsTh cell developmentImmunomodulatory strategiesPathophysiologic abnormalitiesInflammatory diseasesRespiratory tractTh2 cellsImmune responseTraditional therapiesCell differentiationBronchial airwaysAsthmaTherapyCell functionCell effectsCytokinesDiseaseCell developmentMolecular mechanisms