2009
Advances in Mucous Cell Metaplasia
Curran DR, Cohn L. Advances in Mucous Cell Metaplasia. American Journal Of Respiratory Cell And Molecular Biology 2009, 42: 268-275. PMID: 19520914, PMCID: PMC2830403, DOI: 10.1165/rcmb.2009-0151tr.BooksConceptsMucous cell metaplasiaCell metaplasiaMucous metaplasiaChronic obstructive pulmonary diseaseChronic airway diseasesObstructive pulmonary diseaseExacerbation of asthmaChronic airwayAirway obstructionAirway diseaseMucus hypersecretionPulmonary diseaseMolecular mechanismsHarmful insultsIL-13MUC5AC expressionEpidermal growth factor receptor (EGFR) activationGoblet cell granulesGrowth factor receptor activationMucin productionMucus productionNew therapiesGoblet cellsFront-line protectionMetaplasia
2004
Asthma: Mechanisms of Disease Persistence and Progression
Cohn L, Elias JA, Chupp GL. Asthma: Mechanisms of Disease Persistence and Progression. Annual Review Of Immunology 2004, 22: 789-815. PMID: 15032597, DOI: 10.1146/annurev.immunol.22.012703.104716.BooksConceptsIL-13Key effector cytokineAnti-inflammatory therapyIL-13 productionProduction of chemokinesProgression of diseaseAirway fibrosisAllergic asthmaAirway remodelingEffector cytokinesEosinophilic inflammationPersistent diseaseTh2 cytokinesEpithelial damageDisease progressionInflammatory responseTh2 cellsMucus productionSmooth muscleBronchial airwaysMatrix metalloproteinasesAnimal dataAsthmaDisease persistenceInflammation
2001
A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation
Das J, Chen C, Yang L, Cohn L, Ray P, Ray A. A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation. Nature Immunology 2001, 2: 45-50. PMID: 11135577, DOI: 10.1038/83158.Peer-Reviewed Original ResearchConceptsAllergic airway inflammationT helper 2GATA-3 expressionTh2 differentiationAirway inflammationGATA3 expressionAirway eosinophilic inflammationTh2 cytokine productionT-bet expressionInterferon-γ ProductionTh2 cell recruitmentTranscription factor GATA-3NF-κB activityNuclear factor κBT cell receptorEosinophilic inflammationHelper 2Asthma pathogenesisCytokine productionIL-13IL-5Th2 cellsT cellsInterleukin-4Cell recruitment
1999
Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3
Zhang D, Yang L, Cohn L, Parkyn L, Homer R, Ray P, Ray A. Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3. Immunity 1999, 11: 473-482. PMID: 10549629, DOI: 10.1016/s1074-7613(00)80122-3.Peer-Reviewed Original ResearchMeSH KeywordsAerosolsAmino Acid SubstitutionAnimalsAsthmaBronchoalveolar Lavage FluidDNA-Binding ProteinsDrug HypersensitivityEosinophiliaGATA3 Transcription FactorGene Expression RegulationGenes, DominantImmunizationImmunoglobulin EInflammationInterleukin-13Interleukin-4Interleukin-5LungMiceMice, Inbred C57BLMice, TransgenicMucusMutagenesis, Site-DirectedOvalbuminTh2 CellsTrans-ActivatorsConceptsCytokines IL-4GATA-3IL-13IL-4IL-5Th2 cytokines IL-4Pathogenesis of asthmaTreatment of asthmaTranscription factor GATA-3Potential therapeutic targetAirway eosinophiliaTh2 responsesAllergic inflammationAllergic diseasesTh2 cytokinesT-cell-specific fashionTh1 cellsIgE synthesisTh2 cellsMucus productionMurine modelTherapeutic targetTransgenic miceAsthmaDominant negative mutant