2023
Insomnia and Early Incident Atrial Fibrillation: A 16‐Year Cohort Study of Younger Men and Women Veterans
Gaffey A, Rosman L, Lampert R, Yaggi H, Haskell S, Brandt C, Enriquez A, Mazzella A, Skanderson M, Burg M. Insomnia and Early Incident Atrial Fibrillation: A 16‐Year Cohort Study of Younger Men and Women Veterans. Journal Of The American Heart Association 2023, 12: e030331. PMID: 37791503, PMCID: PMC10757545, DOI: 10.1161/jaha.123.030331.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaIncident atrial fibrillationAtrial fibrillationHealth care utilizationSleep apneaAF onsetCohort studyCare utilizationAF riskMultivariate Cox proportional hazards modelVeterans Health Administration (VHA) careRisk of AFCox proportional hazards modelCases of AFEarly cardiovascular riskIncident AF riskAssociation of insomniaProportional hazards modelCommon sleep disorderPost-9/11 veteransElectronic health recordsAF incidenceCardiovascular riskClinical comorbiditiesLifestyle factorsSex‐Specific Associations of Obstructive Sleep Apnea Risk With Patient Characteristics and Functional Outcomes After Acute Myocardial Infarction: Evidence From the VIRGO Study
Gupta A, Barthel A, Mahajan S, Dreyer R, Yaggi H, Bueno H, Lichtman J, Krumholz H. Sex‐Specific Associations of Obstructive Sleep Apnea Risk With Patient Characteristics and Functional Outcomes After Acute Myocardial Infarction: Evidence From the VIRGO Study. Journal Of The American Heart Association 2023, 12: e027225. PMID: 37702090, PMCID: PMC10547292, DOI: 10.1161/jaha.122.027225.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaAcute myocardial infarctionHigh OSA riskOSA riskSex-specific associationsFunctional outcomeHealth statusHigh riskVIRGO StudyMyocardial infarctionDepressive symptomsHistory of OSATime of AMIImpact of OSAObstructive sleep apnea riskLow-risk patientsSleep apnea riskMajority of patientsTime of presentationSex-specific outcomesWorse health statusHigh-risk menPoor health statusMental health statusPoor health outcomesMorning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea.
Knauert M, Adekolu O, Xu Z, Deng A, Chu J, Baldassarri S, Kushida C, Yaggi H, Zinchuk A. Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea. Annals Of The American Thoracic Society 2023, 20: 1182-1191. PMID: 36917194, PMCID: PMC10405611, DOI: 10.1513/annalsats.202210-885oc.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaCPAP adherenceMorning chronotypeCPAP useSleep apneaClinical trialsMorningness-Eveningness QuestionnaireSleep durationContinuous positive airway pressure therapyPositive airway pressure therapyContinuous positive airway pressureSevere obstructive sleep apneaChronotype of patientsDaily CPAP useAirway pressure therapyPositive airway pressureShort sleep durationCPAP armAirway pressureObese menPressure therapyPoor adherenceWeekend catchAdherence dataEvening chronotypeSleep-related predictors of cognition among adults with chronic insomnia and heart failure enrolled in a randomized controlled trial of cognitive behavioral therapy for insomnia.
Redeker N, Conley S, O'Connell M, Geer J, Yaggi H, Jeon S. Sleep-related predictors of cognition among adults with chronic insomnia and heart failure enrolled in a randomized controlled trial of cognitive behavioral therapy for insomnia. Journal Of Clinical Sleep Medicine 2023, 19: 1073-1081. PMID: 36740924, PMCID: PMC10235706, DOI: 10.5664/jcsm.10498.Peer-Reviewed Original ResearchConceptsChronic heart failureCognitive behavioral therapyHeart failureGroup time effectsRest-activity rhythmBehavioral therapyChronic insomniaCBT-I groupSelf-reported cognitive functionProportion of participantsTrial of CBTQuality of lifeSelf-management strategiesGroup-based CBTWalk distanceSleep apneaChronic illnessWrist actigraphyCognitive impairmentInsomniaTherapyCognitive functionMinute walkSelf-reported cognitive abilitiesBaseline cognitionNicotine, alcohol, and caffeine use among individuals with untreated obstructive sleep apnea
Baldassarri S, Chu J, Deng A, Xu Z, Blohowiak R, Byrne S, Kushida C, Yaggi H, Zinchuk A. Nicotine, alcohol, and caffeine use among individuals with untreated obstructive sleep apnea. Sleep And Breathing 2023, 27: 2479-2490. PMID: 37058215, PMCID: PMC10576010, DOI: 10.1007/s11325-023-02830-3.Peer-Reviewed Original ResearchConceptsUntreated obstructive sleep apneaObstructive sleep apneaApnea Positive Pressure Long-term Efficacy StudySubstance useDaytime symptomsSleep characteristicsSleep durationCaffeine useModerate caffeine useLong-term Efficacy StudyCurrent cigarette smokersHeavy caffeine usersObjective sleep characteristicsShort sleep durationModerate alcohol useMore REM sleepLower sleep durationHeavy alcohol usersCross-sectional analysisPsychoactive substance useCurrent smokersCurrent smokingComorbid conditionsMedian BMISleep apnea
2022
Insomnia with objective short sleep duration in community‐living older persons: A multifactorial geriatric health condition
Miner B, Doyle M, Knauert M, Yaggi H, Stone K, Ancoli‐Israel S, Cauley J, Redline S, Blackwell T, Gill T, Groups F. Insomnia with objective short sleep duration in community‐living older persons: A multifactorial geriatric health condition. Journal Of The American Geriatrics Society 2022, 71: 1198-1208. PMID: 36524599, PMCID: PMC10089942, DOI: 10.1111/jgs.18195.Peer-Reviewed Original ResearchConceptsShort sleep durationObjective short sleep durationCommunity-living older personsSleep durationOsteoporotic fracturesOlder menCommunity-living older menOlder personsMultiple predisposingHealth conditionsMen Sleep StudyModifiable risk factorsSeparate logistic regression modelsPoor sleep qualityHigh-risk phenotypeCross-sectional studyCross-sectional associationsMiddle-aged personsLogistic regression modelsClinical correlatesRisk factorsMultivariable modelSleep studiesSleep qualityOlder womenSelf-reported and actigraphic short sleep duration in older adults.
Miner B, Stone KL, Zeitzer JM, Han L, Doyle M, Blackwell T, Gill TM, Redeker NS, Hajduk A, Yaggi H. Self-reported and actigraphic short sleep duration in older adults. Journal Of Clinical Sleep Medicine 2022, 18: 403-413. PMID: 34338629, PMCID: PMC8804982, DOI: 10.5664/jcsm.9584.Peer-Reviewed Original ResearchConceptsShort sleep durationSelf-reported sleep durationSleep durationOsteoporotic fracturesAdverse outcomesOlder personsOlder adultsMen Sleep StudyNormal sleep durationActigraphic sleep durationDaytime sleepinessMultivariable modelShort sleepSleep studiesUnnecessary interventionsSymptom awarenessAverage ageHealth outcomesAge groupsLogistic regressionFalse negativesWomenObesityOutcomesMen
2017
Sleep Disturbance Among HIV-Infected and Uninfected Veterans
Womack JA, Murphy TE, Bathulapalli H, Akgün KM, Gibert C, Kunisaki KM, Rimland D, Rodriguez-Barradas M, Yaggi H, Justice AC, Redeker NS. Sleep Disturbance Among HIV-Infected and Uninfected Veterans. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2017, 74: e117-e120. PMID: 27906767, PMCID: PMC5326673, DOI: 10.1097/qai.0000000000001264.Peer-Reviewed Original Research
2011
Use of Lambda-Mu-Sigma-Derived Z Score for Evaluating Respiratory Impairment in Middle-Aged Persons
Fragoso C, Gill TM, McAvay G, Van Ness PH, Yaggi HK, Concato J. Use of Lambda-Mu-Sigma-Derived Z Score for Evaluating Respiratory Impairment in Middle-Aged Persons. Respiratory Care 2011, 56: 1771-1777. PMID: 21605489, PMCID: PMC3676885, DOI: 10.4187/respcare.01192.Peer-Reviewed Original ResearchConceptsRespiratory symptomsRespiratory impairmentMiddle-aged personsZ-scoreAirflow limitationSpirometric valuesParticipants ages 45Normal age-related changesNutrition Examination SurveyThird National HealthLambda-muMiddle-age personsAge-related changesPulmonary functionExamination SurveyAtherosclerosis RiskNational HealthAge 45Spirometric dataSymptomsMortalityCommunity studyImpairmentScoresValid strategy
2010
Auto-Titrating Continuous Positive Airway Pressure for Patients With Acute Transient Ischemic Attack
Bravata DM, Concato J, Fried T, Ranjbar N, Sadarangani T, McClain V, Struve F, Zygmunt L, Knight HJ, Lo A, Richerson GB, Gorman M, Williams LS, Brass LM, Agostini J, Mohsenin V, Roux F, Yaggi HK. Auto-Titrating Continuous Positive Airway Pressure for Patients With Acute Transient Ischemic Attack. Stroke 2010, 41: 1464-1470. PMID: 20508184, PMCID: PMC4567557, DOI: 10.1161/strokeaha.109.566745.Peer-Reviewed Original ResearchConceptsRecurrent vascular eventsVascular event ratesIntervention patientsSleep apneaTIA patientsVascular eventsContinuous positive airway pressure (CPAP) adherenceAcute transient ischemic attackTransient ischemic attack patientsContinuous positive airway pressurePositive airway pressure adherenceEvent ratesTransient ischemic attackPositive airway pressureCongestive heart failureMajority of patientsSleep apnea patientsIschemic attackRecurrent TIAAirflow obstructionAirway pressureControl patientsCPAP useHeart failureMyocardial infarction
2009
The Ratio of FEV1 to FVC as a Basis for Establishing Chronic Obstructive Pulmonary Disease
Vaz Fragoso CA, Concato J, McAvay G, Van Ness PH, Rochester CL, Yaggi HK, Gill TM. The Ratio of FEV1 to FVC as a Basis for Establishing Chronic Obstructive Pulmonary Disease. American Journal Of Respiratory And Critical Care Medicine 2009, 181: 446-451. PMID: 20019341, PMCID: PMC3159085, DOI: 10.1164/rccm.200909-1366oc.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseFEV1/FVCObstructive pulmonary diseaseRisk of deathRespiratory symptomsPulmonary diseaseAdjusted hazard ratioRatio of FEV1Hazard ratioOdds ratioFVCClinical validityFifth percentileZ-scoreIdentifies personsSymptomsWhite personsDiseaseMeaningful outcomesDeathLambda-muPrevalenceRiskRepresentative sampleHigh thresholdObstructive Sleep Apnea as a Risk Factor for Type 2 Diabetes
Botros N, Concato J, Mohsenin V, Selim B, Doctor K, Yaggi HK. Obstructive Sleep Apnea as a Risk Factor for Type 2 Diabetes. The American Journal Of Medicine 2009, 122: 1122-1127. PMID: 19958890, PMCID: PMC2799991, DOI: 10.1016/j.amjmed.2009.04.026.Peer-Reviewed Original ResearchConceptsMore severe sleep apneaPositive airway pressure useSevere sleep apneaObstructive sleep apneaRisk of diabetesSleep apneaRisk factorsIncident diabetesMAIN OUTCOMEPositive airway pressure therapyType 2 diabetes mellitusVeterans Affairs Connecticut Healthcare SystemAirway pressure therapyObservational cohort studyApnea-hypopnea indexSleep-disordered breathingBody mass indexCross-sectional studyCohort studyDiagnostic polysomnogramGlucose intoleranceConsecutive patientsDiabetes mellitusMass indexPhysician diagnosisThe effect of gender on the prevalence of hypertension in obstructive sleep apnea
Mohsenin V, Yaggi HK, Shah N, Dziura J. The effect of gender on the prevalence of hypertension in obstructive sleep apnea. Sleep Medicine 2009, 10: 759-762. PMID: 19185538, DOI: 10.1016/j.sleep.2008.09.005.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaApnea-hypopnea indexPrevalence of hypertensionSD ageSleep apneaOSA groupContext of OSASeverity of OSAMultiple logistic regression analysisSleep disorder evaluationOdds of hypertensionClinic-based populationSleep apnea severityEffect of genderCross-sectional studyLogistic regression analysisHypertension increasesPrevalent hypertensionSystemic hypertensionObese menHighest quartileApnea severityHypertensionLarge cohortHigh risk
2005
Obstructive Sleep Apnea as a Risk Factor for Stroke and Death
Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive Sleep Apnea as a Risk Factor for Stroke and Death. New England Journal Of Medicine 2005, 353: 2034-2041. PMID: 16282178, DOI: 10.1056/nejmoa043104.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeSleep apnea syndromeApnea-hypopnea indexMean apnea-hypopnea indexRisk of strokeApnea syndromeRisk factorsSleep apneaComposite end pointObservational cohort studyObstructive sleep apneaProportional hazards analysisComparison groupAlcohol consumption statusBody mass indexImportant risk factorCohort studyComposite outcomeConsecutive patientsDiabetes mellitusSmoking statusAtrial fibrillationUnadjusted analysesSyndromePatients