2023
Design and methods of a randomized trial testing "Advancing care for COPD in people living with HIV by implementing evidence-based management through proactive E-consults (ACHIEVE)"
Ives J, Bagchi S, Soo S, Barrow C, Akgün K, Erlandson K, Goetz M, Griffith M, Gross R, Hulgan T, Moanna A, Soo Hoo G, Weintrob A, Wongtrakool C, Adams S, Sayre G, Helfrich C, Au D, Crothers K. Design and methods of a randomized trial testing "Advancing care for COPD in people living with HIV by implementing evidence-based management through proactive E-consults (ACHIEVE)". Contemporary Clinical Trials 2023, 132: 107303. PMID: 37481201, PMCID: PMC10528346, DOI: 10.1016/j.cct.2023.107303.Peer-Reviewed Original ResearchMeSH KeywordsChronic DiseaseComorbidityHIV InfectionsHumansPulmonary Disease, Chronic ObstructiveVeteransConceptsChronic obstructive pulmonary diseaseE-consultsEvidence-based managementElectronic health recordsCOPD managementVeterans Affairs Medical CenterCommon comorbid diseasesObstructive pulmonary diseaseChronic disease comorbiditiesEvidence-based careEvidence-based recommendationsComorbid diseasesPulmonary diseaseHIV populationInappropriate therapyBlood InstituteNational HeartACHIEVE trialMedical CenterClinical providersDisease comorbiditiesHIVPWHTrial testingCareAdvance directive screening among veterans with incident heart failure: Comparisons among people aging with and without HIV
Walenczyk K, Cavanagh C, Skanderson M, Feder S, Soliman A, Justice A, Burg M, Akgün K. Advance directive screening among veterans with incident heart failure: Comparisons among people aging with and without HIV. Heart & Lung 2023, 61: 1-7. PMID: 37023581, PMCID: PMC10524135, DOI: 10.1016/j.hrtlng.2023.03.018.Peer-Reviewed Original ResearchConceptsIncident heart failureVeterans Aging Cohort StudyHeart failureAD screeningDisease severityCox proportional hazards regressionIncident HF diagnosisAging Cohort StudyProportional hazards regressionGreater disease severityAdvance directive completionAssociation of ADFuture quality improvementCare contactsCohort studyHF diagnosisHIV statusScreening ratesHazards regressionPoor prognosisDiagnosis codesCardiology subspecialtiesHaenszel testHealthcare encountersPWHDelirium among people aging with and without HIV: Role of alcohol and Neurocognitively active medications
Akgün K, Krishnan S, Tate J, Bryant K, Pisani M, Re V, Rentsch C, Crothers K, Gordon K, Justice A, team F. Delirium among people aging with and without HIV: Role of alcohol and Neurocognitively active medications. Journal Of The American Geriatrics Society 2023, 71: 1861-1872. PMID: 36786300, PMCID: PMC10258127, DOI: 10.1111/jgs.18265.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification Test-ConsumptionActive medicationAlcohol useOdds ratioRelative riskDose-response associationDate of admissionSeverity of illnessIndependent dose-response associationsRace/ethnicityInpatient deliriumIndex dateMedication exposureRole of alcoholHIV statusMultivariable analysisMedication countNeurocognitive dysfunctionUnderappreciated causeDeliriumHigh incidencePWHMedicationsPWOHLogistic regression
2020
Associations of marijuana with markers of chronic lung disease in people living with HIV
Wenger D, Triplette M, Shahrir S, Akgun K, Wongtrakool C, Brown, Kim J, Hoo G, Rodriguez‐Barradas M, Huang L, Feemster L, Zifodya J, Crothers K. Associations of marijuana with markers of chronic lung disease in people living with HIV. HIV Medicine 2020, 22: 92-101. PMID: 33022830, DOI: 10.1111/hiv.12966.Peer-Reviewed Original ResearchConceptsChronic lung diseaseLung diseaseMarijuana smokingRadiographic emphysemaMarijuana exposureHIV-Associated Lung Emphysema (EXHALE) studyLarger total lung capacityHIV-positive patientsTotal lung capacityHigh lung volumesCross-sectional analysisMarijuana useAssociation of marijuanaExpiratory volumeTobacco smokingVital capacityLung capacityLung healthLung volumeSmokingWeekly marijuana useHIVPLWHLogistic regressionEmphysema
2019
Racial Differences in Change in Physical Functioning in Older Male Veterans with HIV
McKellar MS, Kuchibhatla MN, Oursler KAK, Crystal S, Akgün K, Crothers K, Gibert CL, Nieves-Lugo K, Womack J, Tate J, Fillenbaum GG. Racial Differences in Change in Physical Functioning in Older Male Veterans with HIV. AIDS Research And Human Retroviruses 2019, 35: 1034-1043. PMID: 30963773, PMCID: PMC6862951, DOI: 10.1089/aid.2018.0296.Peer-Reviewed Original ResearchConceptsPCS scoresPhysical functioningWhite HIVHIV statusMale veteransHealth behaviorsSF-12 physical component summary scorePhysical component summary scoreLower body mass indexHealth conditionsBetter PCS scoresPoorer PCS scoreHIV-negative menLower PCS scoresComponent summary scoresBody mass indexViral load countOlder male veteransChronic health conditionsLack of exerciseBetter health behaviorsWhite male veteransAssociation of demographicGeneral U.S. populationLow socioeconomic status
2017
The Differential Impact of Emphysema on Respiratory Symptoms and 6-Minute Walk Distance in HIV Infection
Triplette M, Attia E, Akgün K, Campo M, Rodriguez-Barradas M, Pipavath S, Shahrir S, Wongtrakool C, Goetz M, Kim J, Soo Hoo G, Brown ST, Crothers K. The Differential Impact of Emphysema on Respiratory Symptoms and 6-Minute Walk Distance in HIV Infection. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2017, 74: e23-e29. PMID: 27716727, PMCID: PMC5140705, DOI: 10.1097/qai.0000000000001133.Peer-Reviewed Original ResearchConceptsHIV subjectsChronic coughRespiratory symptomsAirflow obstructionWalk distanceRadiographic emphysemaAssociation of emphysemaHIV uninfected subjectsPulmonary function testingCross-sectional analysisPulmonary symptomsCohort studyHIV infectionHIV statusFunction testingClinical impactEmphysemaEmphysema severitySmoking behaviorMild formSymptomsCoughGreater burdenPhlegmHealth effects
2015
Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia
Barakat LA, Juthani-Mehta M, Allore H, Trentalange M, Tate J, Rimland D, Pisani M, Akgün KM, Goetz MB, Butt AA, Rodriguez-Barradas M, Duggal M, Crothers K, Justice AC, Quagliarello VJ. Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia. HIV Medicine 2015, 16: 421-430. PMID: 25959543, PMCID: PMC5015437, DOI: 10.1111/hiv.12244.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaVeterans Aging Cohort StudyVACS IndexCAP outcomesAntiretroviral therapyOlder adultsHigher VACS indexDays of dischargeAging Cohort StudyUninfected participantsCohort studyMean LOSHIV infectionLonger LOSClinical outcomesUnadjusted analysesUninfected groupMultivariable modelEligibility criteriaHIVMale veteransMortality rateART useMortalityOutcomes